Статья
THE FIRST TOTAL SYNTHESIS OF THE MARINE ACETYLENIC ALCOHOL, LEMBEHYNE B – A SELECTIVE INDUCER OF EARLY APOPTOSIS IN LEUKEMIA CANCER CELLS
2017
The communication reports a new stereoselective method for the synthesis of a natural acetylenic alcohol, lembehyne B. The key stage of the process uses new cross-cyclomagnesiation reaction of aliphatic and oxygenated 1,2-dienes with Grignard reagents in the presence of a catalytic amount of Cp2TiCl2. A study of the cytotoxic properties of lembehyne B on tumor cell lines using flow cytometry demonstrated that this is a selective inducer of early apoptosis of the Jurkat, HL-60 and K562 cell cultures and hypodiploid (sub-G1) sub-population inducer in cell cycle studies for all cell lines used.
Dzhemileva, L.U., D'yakonov, V.A., Makarov, A.A., Andreev, E.N., Yunusbaeva, M.M., Dzhemilev, U.M. . 2017; https://doi.org/10.1039/C6OB02346K
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