17 Dzhemileva, L.U. D'yakonov, V.A. Makarov, A.A. Andreev, E.N. Yunusbaeva, M.M. Dzhemilev, U.M. 2017 2018-01-24 10.1039/C6OB02346K The communication reports a new stereoselective method for the synthesis of a natural acetylenic alcohol, lembehyne B. The key stage of the process uses new cross-cyclomagnesiation reaction of aliphatic and oxygenated 1,2-dienes with Grignard reagents in the presence of a catalytic amount of Cp2TiCl2. A study of the cytotoxic properties of lembehyne B on tumor cell lines using flow cytometry demonstrated that this is a selective inducer of early apoptosis of the Jurkat, HL-60 and K562 cell cultures and hypodiploid (sub-G1) sub-population inducer in cell cycle studies for all cell lines used. https://repo.bashgmu.ru/publication/941 https://repo.bashgmu.ru/files/1068