Статья
NOVEL HYBRID MOLECULES ON THE BASIS OF STEROIDS AND (5Z,9Z)-TETRADECA-5,9-DIENOIC ACID: SYNTHESIS, ANTI-CANCER STUDIES AND HUMAN TOPOISOMERASE I INHIBITORY ACTIVITY
2017
Novel steroid derivatives of 5Z,9Z-dienoic acids were prepared by the DCC/DMAP-catalyzed esterification of (5Z,9Z)-tetradeca-5,9-dienoic acid with hydroxy steroids. High cytotoxicity towards the HEK293, Jurkat, K562 cancer cell lines and human topoisomerase I (hTop1) inhibitory activity in vitro were found for the synthesized acids. A probable mechanism of topoisomerase I inhibition was hypothesized on the basis of in silico studies resorting to docking.
D’yakonov, V.A., Dzhemileva, L.U., Tuktarova, R.A., Ishmukhametova, S.R., Yunusbaeva, M.M., Ramazanov, I.R., Dzhemilev, U.M. . 2017;
Цитирование
