%0 Article
%A Dzhemileva, L.U., 
%A D'yakonov, V.A., 
%A Makarov, A.A., 
%A Andreev, E.N., 
%A Yunusbaeva, M.M., 
%A Dzhemilev, U.M., 
%T 
%D 2017
%R 10.1039/C6OB02346K
%X The communication reports a new stereoselective method for the synthesis of a natural acetylenic alcohol, lembehyne B. The key stage of the process uses new cross-cyclomagnesiation reaction of aliphatic and oxygenated 1,2-dienes with Grignard reagents in the presence of a catalytic amount of Cp2TiCl2. A study of the cytotoxic properties of lembehyne B on tumor cell lines using flow cytometry demonstrated that this is a selective inducer of early apoptosis of the Jurkat, HL-60 and K562 cell cultures and hypodiploid (sub-G1) sub-population inducer in cell cycle studies for all cell lines used.
%U https://repo.bashgmu.ru/publication/941