RT - Article
SR - Electronic
T1 - 
SP - 2018-01-24
DO - 10.1039/C6OB02346K
A1 - Dzhemileva, L.U., 
A1 - D'yakonov, V.A., 
A1 - Makarov, A.A., 
A1 - Andreev, E.N., 
A1 - Yunusbaeva, M.M., 
A1 - Dzhemilev, U.M., 
YR - 2017
UL - https://repo.bashgmu.ru/publication/941
AB - The communication reports a new stereoselective method for the synthesis of a natural acetylenic alcohol, lembehyne B. The key stage of the process uses new cross-cyclomagnesiation reaction of aliphatic and oxygenated 1,2-dienes with Grignard reagents in the presence of a catalytic amount of Cp2TiCl2. A study of the cytotoxic properties of lembehyne B on tumor cell lines using flow cytometry demonstrated that this is a selective inducer of early apoptosis of the Jurkat, HL-60 and K562 cell cultures and hypodiploid (sub-G1) sub-population inducer in cell cycle studies for all cell lines used.