Статья

DIVERSITY-ORIENTED SYNTHESIS OF SPIROTHIAZOLIDINEDIONES AND THEIR BIOLOGICAL EVALUATION

KOTHA SAMBASIVARAO, SREEVANI GADDAMEDI, DZHEMILEVA, LILYA U, YUNUSBAEVA, MILYAUSHA M, DZHEMILEV, USEIN M, D'YAKONOV, VLADIMIR A
2019
https://doi.org/10.3762/bjoc.15.269

We report a new synthetic approach to assemble spirothiazolidinediones via a [2 + 2 + 2] cyclotrimerization reaction and the derivatives were further functionalized through DA chemistry and click reaction. Using flow cytometry, it was shown for the first time that the new benzyl alcohol derivatives of thiazolidine-2,4-dione generated here are efficient apoptosis inducers in the HeLa, Hek293, U937, Jurkat, and K562 cell lines.

. 2019; https://doi.org/10.3762/bjoc.15.269
Цитирование

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Документы

Информация

Автор
Рубрика
  • APOPTOSIS, BIOLOGICALLY ACTIVE, [2 + 2 + 2] CYCLOADDITION, FLOW CYTOMETRY, SPIRO THIAZOLIDINEDIONE, Scopus, Web of Science
Год публикации
  • 2019
Издатель
  • Beilstein - Institut zur Foerderung der Chemischen Wissenschaften
Тип документа
  • Article
Коллекции
Федеральное государственное бюджетное образовательное учреждение высшего образования «Башкирский государственный медицинский университет» Министерства здравоохранения Российской Федерации
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