Статья
SYNTHESIS AND ANTIDIABETIC ACTIVITY OF THIAZOLO[2,3-F]PURINE DERIVATIVES AND THEIR ANALOGS
2017
Thiazolo[2, 3-f]purine derivatives and their analogs – dihydrothiazolo[2, 3-f]purine, 7-(thietan-3-yl)purine, and 8-(2-hydroxypropylthio)purine derivatives – were synthesized. The compounds synthesized here had no effects on protein glycation reactions using glucose; they gave weak inhibition of glycogen phosphorylase; they had no hemorheological activity. Substances with hypotensive activity greater than that of Dibazol were found. A number of substances had hypoglycemic effects greater than those of chlorpropamide and Adebit. Two compounds inhibited dipeptidylpeptidase-4, but were less active than reference agent vildagliptin.
Spasov, A.A., Khaliullin, F.A., Babkov, D.A., Timirkhanova, G.A., Kuznetsova, V.A., Naumenko, L.V., Muleeva, D.R., Maika, O.Yu., Prokhorova, T.Yu., Sturova, E.A. . 2017; https://doi.org/10.1007/s11094-017-1649-5
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