Thiazolo[2, 3-f]purine derivatives and their analogs – dihydrothiazolo[2, 3-f]purine, 7-(thietan-3-yl)purine,
and 8-(2-hydroxypropylthio)purine derivatives – were synthesized. The compounds synthesized here had no
effects on protein glycation reactions using glucose; they gave weak inhibition of glycogen phosphorylase;
they had no hemorheological activity. Substances with hypotensive activity greater than that of Dibazol were
found. A number of substances had hypoglycemic effects greater than those of chlorpropamide and Adebit.
Two compounds inhibited dipeptidylpeptidase-4, but were less active than reference agent vildagliptin.