Objective. To investigate clinical manifestations of multiple sclerosis (MS) and the genetic makeup of six affected members of one
family. Material and methods. Six members of the family of Russian ethnic origin were examined. Pedigree analysis and genotyping
of polymorphic markers of candidate genes for multiple sclerosis were performed. Results and conclusion. The accumulation of
alleles that were associated with autoimmune diseases according to the results of genome-wide association studies (rs1109670*C,
rs3129934*T, rs9523762*G, rs1570538*T) was found in the family. The results confirm the contribution of several genetic variants
to familial forms of MS.