Статья
SYNTHESIS OF PYRINIDINE-2,4(1Н,3Н)-DIONE DERIVATIVES CONTAINING N-ALKYL SUBSTITUENTS
2017
6-Methyluracil derivatives containing a gem-dichlorocyclopropane and a 1,3-dioxolane fragments were synthesized for the first time. The condensation of 6-methyluracil with chloromethyl derivatives gives a mixture of N1 - and N3 -monosubstituted products, and the profound N-alkylation of this compound provides disubstituted uracils. The structure of the synthesized compounds was studied by H1 and 13С NMR spectroscopy and their relative antioxidant activity was evaluated by luminol-dependent chemiluminescence measurements.
Raskildinaa, G.Z., Valieva, V.F., Ozdena, I.V., Meshcheryakova, S.A., Spirikhin, L.V., Zlotskiia, S.S. . 2017;
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