%0 Article
%A D’yakonov, V.A., 
%A Dzhemileva, L.U., 
%A Tuktarova, R.A., 
%A Ishmukhametova, S.R., 
%A Yunusbaeva, M.M., 
%A Ramazanov, I.R., 
%A Dzhemilev, U.M., 
%T 
%D 2017
%X Novel steroid derivatives of 5Z,9Z-dienoic acids were prepared by the DCC/DMAP-catalyzed esterification of (5Z,9Z)-tetradeca-5,9-dienoic acid with hydroxy steroids. High cytotoxicity towards the HEK293, Jurkat, K562 cancer cell lines and human topoisomerase I (hTop1) inhibitory activity in vitro were found for the synthesized acids. A probable mechanism of topoisomerase I inhibition was hypothesized on the basis of in silico studies resorting to docking.
%U https://repo.bashgmu.ru/publication/637