RT - Article
SR - Electronic
T1 - 
SP - 2018-01-31
A1 - D’yakonov, V.A., 
A1 - Dzhemileva, L.U., 
A1 - Tuktarova, R.A., 
A1 - Ishmukhametova, S.R., 
A1 - Yunusbaeva, M.M., 
A1 - Ramazanov, I.R., 
A1 - Dzhemilev, U.M., 
YR - 2017
UL - https://repo.bashgmu.ru/publication/637
AB - Novel steroid derivatives of 5Z,9Z-dienoic acids were prepared by the DCC/DMAP-catalyzed esterification of (5Z,9Z)-tetradeca-5,9-dienoic acid with hydroxy steroids. High cytotoxicity towards the HEK293, Jurkat, K562 cancer cell lines and human topoisomerase I (hTop1) inhibitory activity in vitro were found for the synthesized acids. A probable mechanism of topoisomerase I inhibition was hypothesized on the basis of in silico studies resorting to docking.