@article{D’yakonov, V.A.2018-01-31, author = { D’yakonov, V.A., Dzhemileva, L.U., Tuktarova, R.A., Ishmukhametova, S.R., Yunusbaeva, M.M., Ramazanov, I.R., Dzhemilev, U.M.}, title = {}, year = {2017}, publisher = {NP «NEICON»}, abstract = {Novel steroid derivatives of 5Z,9Z-dienoic acids were prepared by the DCC/DMAP-catalyzed esterification of (5Z,9Z)-tetradeca-5,9-dienoic acid with hydroxy steroids. High cytotoxicity towards the HEK293, Jurkat, K562 cancer cell lines and human topoisomerase I (hTop1) inhibitory activity in vitro were found for the synthesized acids. A probable mechanism of topoisomerase I inhibition was hypothesized on the basis of in silico studies resorting to docking.}, URL = {https://repo.bashgmu.ru/publication/637}, eprint = {https://repo.bashgmu.ru/files/705}, }