G(8344) mutation as the only manifestation of disease in a carrier of myoclonus epilepsy and ragged-red fibers (MERRF) syndrome. Am J Hum Genet. 1993r;52(3):551–6. PMID: 8447321","Мазунин И.О., Володько Н.В., Стариковская Е.Б., Сукерник Р.И. Митохондриальный геном и митохондриальные заболевания человека. Молекулярная биология. 2010;44(5):755–72.","Celentano V., Esposito E., Perrotta S., Giglio M.C., Tarquini R., Luglio G., et al. Madelung disease: report of a case and review of the literature. Acta Chir Belg. 2014;114(6):417–20. PMID: 26021689","Lemaitre M., Chevalier B., Jannin A., Bourry J., Espiard S., Vantyghem M.C. Multiple symmetric and multiple familial lipomatosis. Presse Med. 2021;50(3):104077. DOI: 10.1016/j.lpm.2021.104077","Вецмадян Е.А., Труфанов Г.Е., Рязанов В.В., Мостовая О.Т., Новиков К.В., Карайванов Н.С. Ультразвуковая диагностика липом мягких тканей с использованием методик цветного допплеровского картирования и эластографии. Вестник Российской Военно-медицинской академии. 2012;2(38):43–50.","Богов А.А., Андреев П.С., Филиппов В.Л., Топыркин В.Г. Оперативное лечение болезни Маделунга. Практическая медицина. 2018;16(7-1):90–3.","Уракова Е.В., Нестеров О.В., Ильина Р.Ю., Лексин Р.В. Хирургическая тактика при рецидивирующем липоматозе (болезни Маделунга). Клинический случай. Практическая медицина. 2022;20(6):131–3.","Егай А.А., Тентимишев А.Э., Норматов Р.М., Тян А.С. Хирургическое лечение множественного симметричного липоматоза (болезнь Маделунга), осложненного сдавлением яремных вен с обеих сторон. Преимущества липэктомии перед липосакцией. Научное обозрение. Медицинские науки. 2022;1:5– 10. DOI: 10.17513/srms.1225","Тимербулатов М.В., Шорнина А.С., Лихтер Р.А., Каипов А.Э. Оценка липосакции в структуре абдоминопластики и сочетанной герниоабдоминопластики. Креативная хирургия и онкология. 2023;13(4):278–83. DOI: 10.24060/2076-3093-2023-13-4-278-283","Dang Y., Du X., Ou X., Zheng Q., Xie F. Advances in diagnosis and treatment of Madelung’s deformity. Am J Transl Res. 2023;15(7):4416–24.","Leti Acciaro A, Garagnani L, Lando M, Lana D, Sartini S, Adani R. Modified dome osteotomy and anterior locking plate fixation for distal radius variant of Madelung deformity: a retrospective study. J Plast Surg Hand Surg. 2022;56(2):121–6. DOI: 10.1080/2000656X.2021.1934845","Liu Q., Lyu H., Xu B., Lee J.H. Madelung disease epidemiology and clinical characteristics: a systemic review. Aesthetic Plast Surg. 2021;45(3):977–86. DOI: 10.1007/s00266-020-02083-5","Sia K.J., Tang I.P., Tan T.Y. Multiple symmetrical lipomatosis: case report and literature review. J Laryngol Otol. 2012;126(7):756–8. DOI: 10.1017/S0022215112000709","Kratz C., Lenard H.G., Ruzicka T., Gärtner J. Multiple symmetric lipomatosis: an unusual cause of childhood obesity and mental retardation. Eur J Paediatr Neurol. 2000;4(2):63–7. DOI: 10.1053/ejpn.2000.0264","Nounla J., Rolle U., Gräfe G., Kräling K. Benign symmetric lipomatosis with myelomeningocele in an adolescent: An uncommon association-case report. J Pediatr Surg. 2001;36(7):E13. DOI: 10.1053/jpsu.2001.24776","Madelung O.W. Über den Fetthals (diffuses Lipom des Halses). Arch Klin Chir. 1888;37:106-30.","Lanois P.E., Bensaude R. De ladeno-lipomatosesymetrique. Bull Mem Soc Med Hosp. 1898;1:298.","El Ouahabi H., Doubi S., Lahlou K., Boujraf S., Ajdi F. Launois-bensaude syndrome: A benign symmetric lipomatosis without alcohol association. Ann Afr Med. 2017;16(1):33–4. DOI: 10.4103/1596-3519.202082","Chen C.Y., Fang Q.Q., Wang X.F., Zhang M.X., Zhao W.Y., Shi B.H., et al. Madelung’s disease: lipectomy or liposuction? Biomed Res Int. 2018;3975974. DOI: 10.1155/2018/3975974","Coker J.E., Bryan J.A. Endocrine and metabolic disorders: Causes and pathogenesis of obesity. J. Fam. Pract. 2008;4:21–6.","González-García R., Rodríguez-Campo F.J., Sastre-Pérez J., Muñoz-Guerra M.F. Benign symmetric lipomatosis (Madelung’s disease): case reports and current management. Aesthetic Plast Surg. 2004;28(2):108– 12; discussion 113. DOI: 10.1007/s00266-004-3123-5","Holme E., Larsson N.G., Oldfors A., Tulinius M., Sahlin P., Stenman G. Multiple symmetric lipomas with high levels of mtDNA with the tRNA(Lys) A-->G(8344) mutation as the only manifestation of disease in a carrier of myoclonus epilepsy and ragged-red fibers (MERRF) syndrome. Am J Hum Genet. 1993r;52(3):551–6. PMID: 8447321","Мазунин И.О., Володько Н.В., Стариковская Е.Б., Сукерник Р.И. Митохондриальный геном и митохондриальные заболевания человека. Молекулярная биология. 2010;44(5):755–72.","Celentano V., Esposito E., Perrotta S., Giglio M.C., Tarquini R., Luglio G., et al. Madelung disease: report of a case and review of the literature. Acta Chir Belg. 2014;114(6):417–20. PMID: 26021689","Lemaitre M., Chevalier B., Jannin A., Bourry J., Espiard S., Vantyghem M.C. Multiple symmetric and multiple familial lipomatosis. Presse Med. 2021;50(3):104077. DOI: 10.1016/j.lpm.2021.104077","Вецмадян Е.А., Труфанов Г.Е., Рязанов В.В., Мостовая О.Т., Новиков К.В., Карайванов Н.С. Ультразвуковая диагностика липом мягких тканей с использованием методик цветного допплеровского картирования и эластографии. Вестник Российской Военно-медицинской академии. 2012;2(38):43–50.","Богов А.А., Андреев П.С., Филиппов В.Л., Топыркин В.Г. Оперативное лечение болезни Маделунга. Практическая медицина. 2018;16(7-1):90–3.","Уракова Е.В., Нестеров О.В., Ильина Р.Ю., Лексин Р.В. Хирургическая тактика при рецидивирующем липоматозе (болезни Маделунга). Клинический случай. Практическая медицина. 2022;20(6):131–3.","Егай А.А., Тентимишев А.Э., Норматов Р.М., Тян А.С. Хирургическое лечение множественного симметричного липоматоза (болезнь Маделунга), осложненного сдавлением яремных вен с обеих сторон. Преимущества липэктомии перед липосакцией. Научное обозрение. Медицинские науки. 2022;1:5– 10. DOI: 10.17513/srms.1225","Тимербулатов М.В., Шорнина А.С., Лихтер Р.А., Каипов А.Э. Оценка липосакции в структуре абдоминопластики и сочетанной герниоабдоминопластики. Креативная хирургия и онкология. 2023;13(4):278–83. DOI: 10.24060/2076-3093-2023-13-4-278-283","Dang Y., Du X., Ou X., Zheng Q., Xie F. Advances in diagnosis and treatment of Madelung’s deformity. Am J Transl Res. 2023;15(7):4416–24.","Leti Acciaro A, Garagnani L, Lando M, Lana D, Sartini S, Adani R. Modified dome osteotomy and anterior locking plate fixation for distal radius variant of Madelung deformity: a retrospective study. J Plast Surg Hand Surg. 2022;56(2):121–6. DOI: 10.1080/2000656X.2021.1934845"],"dc.citation.ru":["Liu Q., Lyu H., Xu B., Lee J.H. Madelung disease epidemiology and clinical characteristics: a systemic review. Aesthetic Plast Surg. 2021;45(3):977–86. DOI: 10.1007/s00266-020-02083-5","Sia K.J., Tang I.P., Tan T.Y. Multiple symmetrical lipomatosis: case report and literature review. J Laryngol Otol. 2012;126(7):756–8. DOI: 10.1017/S0022215112000709","Kratz C., Lenard H.G., Ruzicka T., Gärtner J. Multiple symmetric lipomatosis: an unusual cause of childhood obesity and mental retardation. Eur J Paediatr Neurol. 2000;4(2):63–7. DOI: 10.1053/ejpn.2000.0264","Nounla J., Rolle U., Gräfe G., Kräling K. Benign symmetric lipomatosis with myelomeningocele in an adolescent: An uncommon association-case report. J Pediatr Surg. 2001;36(7):E13. DOI: 10.1053/jpsu.2001.24776","Madelung O.W. Über den Fetthals (diffuses Lipom des Halses). Arch Klin Chir. 1888;37:106-30.","Lanois P.E., Bensaude R. De ladeno-lipomatosesymetrique. Bull Mem Soc Med Hosp. 1898;1:298.","El Ouahabi H., Doubi S., Lahlou K., Boujraf S., Ajdi F. Launois-bensaude syndrome: A benign symmetric lipomatosis without alcohol association. Ann Afr Med. 2017;16(1):33–4. DOI: 10.4103/1596-3519.202082","Chen C.Y., Fang Q.Q., Wang X.F., Zhang M.X., Zhao W.Y., Shi B.H., et al. Madelung’s disease: lipectomy or liposuction? Biomed Res Int. 2018;3975974. DOI: 10.1155/2018/3975974","Coker J.E., Bryan J.A. Endocrine and metabolic disorders: Causes and pathogenesis of obesity. J. Fam. Pract. 2008;4:21–6.","González-García R., Rodríguez-Campo F.J., Sastre-Pérez J., Muñoz-Guerra M.F. Benign symmetric lipomatosis (Madelung’s disease): case reports and current management. Aesthetic Plast Surg. 2004;28(2):108– 12; discussion 113. DOI: 10.1007/s00266-004-3123-5","Holme E., Larsson N.G., Oldfors A., Tulinius M., Sahlin P., Stenman G. Multiple symmetric lipomas with high levels of mtDNA with the tRNA(Lys) A-->G(8344) mutation as the only manifestation of disease in a carrier of myoclonus epilepsy and ragged-red fibers (MERRF) syndrome. Am J Hum Genet. 1993r;52(3):551–6. PMID: 8447321","Мазунин И.О., Володько Н.В., Стариковская Е.Б., Сукерник Р.И. Митохондриальный геном и митохондриальные заболевания человека. Молекулярная биология. 2010;44(5):755–72.","Celentano V., Esposito E., Perrotta S., Giglio M.C., Tarquini R., Luglio G., et al. Madelung disease: report of a case and review of the literature. Acta Chir Belg. 2014;114(6):417–20. PMID: 26021689","Lemaitre M., Chevalier B., Jannin A., Bourry J., Espiard S., Vantyghem M.C. Multiple symmetric and multiple familial lipomatosis. Presse Med. 2021;50(3):104077. DOI: 10.1016/j.lpm.2021.104077","Вецмадян Е.А., Труфанов Г.Е., Рязанов В.В., Мостовая О.Т., Новиков К.В., Карайванов Н.С. Ультразвуковая диагностика липом мягких тканей с использованием методик цветного допплеровского картирования и эластографии. Вестник Российской Военно-медицинской академии. 2012;2(38):43–50.","Богов А.А., Андреев П.С., Филиппов В.Л., Топыркин В.Г. Оперативное лечение болезни Маделунга. Практическая медицина. 2018;16(7-1):90–3.","Уракова Е.В., Нестеров О.В., Ильина Р.Ю., Лексин Р.В. Хирургическая тактика при рецидивирующем липоматозе (болезни Маделунга). Клинический случай. Практическая медицина. 2022;20(6):131–3.","Егай А.А., Тентимишев А.Э., Норматов Р.М., Тян А.С. Хирургическое лечение множественного симметричного липоматоза (болезнь Маделунга), осложненного сдавлением яремных вен с обеих сторон. Преимущества липэктомии перед липосакцией. Научное обозрение. Медицинские науки. 2022;1:5– 10. DOI: 10.17513/srms.1225","Тимербулатов М.В., Шорнина А.С., Лихтер Р.А., Каипов А.Э. Оценка липосакции в структуре абдоминопластики и сочетанной герниоабдоминопластики. Креативная хирургия и онкология. 2023;13(4):278–83. DOI: 10.24060/2076-3093-2023-13-4-278-283","Dang Y., Du X., Ou X., Zheng Q., Xie F. Advances in diagnosis and treatment of Madelung’s deformity. Am J Transl Res. 2023;15(7):4416–24.","Leti Acciaro A, Garagnani L, Lando M, Lana D, Sartini S, Adani R. Modified dome osteotomy and anterior locking plate fixation for distal radius variant of Madelung deformity: a retrospective study. J Plast Surg Hand Surg. 2022;56(2):121–6. DOI: 10.1080/2000656X.2021.1934845"],"dc.citation.en":["Liu Q., Lyu H., Xu B., Lee J.H. Madelung disease epidemiology and clinical characteristics: a systemic review. Aesthetic Plast Surg. 2021;45(3):977–86. DOI: 10.1007/s00266-020-02083-5","Sia K.J., Tang I.P., Tan T.Y. Multiple symmetrical lipomatosis: case report and literature review. J Laryngol Otol. 2012;126(7):756–8. DOI: 10.1017/S0022215112000709","Kratz C., Lenard H.G., Ruzicka T., Gärtner J. Multiple symmetric lipomatosis: an unusual cause of childhood obesity and mental retardation. Eur J Paediatr Neurol. 2000;4(2):63–7. DOI: 10.1053/ejpn.2000.0264","Nounla J., Rolle U., Gräfe G., Kräling K. Benign symmetric lipomatosis with myelomeningocele in an adolescent: An uncommon association-case report. J Pediatr Surg. 2001;36(7):E13. DOI: 10.1053/jpsu.2001.24776","Madelung O.W. Über den Fetthals (diffuses Lipom des Halses). Arch Klin Chir. 1888;37:106-30.","Lanois P.E., Bensaude R. De ladeno-lipomatosesymetrique. Bull Mem Soc Med Hosp. 1898;1:298.","El Ouahabi H., Doubi S., Lahlou K., Boujraf S., Ajdi F. Launois-bensaude syndrome: A benign symmetric lipomatosis without alcohol association. Ann Afr Med. 2017;16(1):33–4. DOI: 10.4103/1596-3519.202082","Chen C.Y., Fang Q.Q., Wang X.F., Zhang M.X., Zhao W.Y., Shi B.H., et al. Madelung’s disease: lipectomy or liposuction? Biomed Res Int. 2018;3975974. DOI: 10.1155/2018/3975974","Coker J.E., Bryan J.A. Endocrine and metabolic disorders: Causes and pathogenesis of obesity. J. Fam. Pract. 2008;4:21–6.","González-García R., Rodríguez-Campo F.J., Sastre-Pérez J., Muñoz-Guerra M.F. Benign symmetric lipomatosis (Madelung’s disease): case reports and current management. Aesthetic Plast Surg. 2004;28(2):108– 12; discussion 113. DOI: 10.1007/s00266-004-3123-5","Holme E., Larsson N.G., Oldfors A., Tulinius M., Sahlin P., Stenman G. Multiple symmetric lipomas with high levels of mtDNA with the tRNA(Lys) A-->G(8344) mutation as the only manifestation of disease in a carrier of myoclonus epilepsy and ragged-red fibers (MERRF) syndrome. Am J Hum Genet. 1993r;52(3):551–6. PMID: 8447321","Мазунин И.О., Володько Н.В., Стариковская Е.Б., Сукерник Р.И. Митохондриальный геном и митохондриальные заболевания человека. Молекулярная биология. 2010;44(5):755–72.","Celentano V., Esposito E., Perrotta S., Giglio M.C., Tarquini R., Luglio G., et al. Madelung disease: report of a case and review of the literature. Acta Chir Belg. 2014;114(6):417–20. PMID: 26021689","Lemaitre M., Chevalier B., Jannin A., Bourry J., Espiard S., Vantyghem M.C. Multiple symmetric and multiple familial lipomatosis. Presse Med. 2021;50(3):104077. DOI: 10.1016/j.lpm.2021.104077","Вецмадян Е.А., Труфанов Г.Е., Рязанов В.В., Мостовая О.Т., Новиков К.В., Карайванов Н.С. Ультразвуковая диагностика липом мягких тканей с использованием методик цветного допплеровского картирования и эластографии. Вестник Российской Военно-медицинской академии. 2012;2(38):43–50.","Богов А.А., Андреев П.С., Филиппов В.Л., Топыркин В.Г. Оперативное лечение болезни Маделунга. Практическая медицина. 2018;16(7-1):90–3.","Уракова Е.В., Нестеров О.В., Ильина Р.Ю., Лексин Р.В. Хирургическая тактика при рецидивирующем липоматозе (болезни Маделунга). Клинический случай. Практическая медицина. 2022;20(6):131–3.","Егай А.А., Тентимишев А.Э., Норматов Р.М., Тян А.С. Хирургическое лечение множественного симметричного липоматоза (болезнь Маделунга), осложненного сдавлением яремных вен с обеих сторон. Преимущества липэктомии перед липосакцией. Научное обозрение. Медицинские науки. 2022;1:5– 10. DOI: 10.17513/srms.1225","Тимербулатов М.В., Шорнина А.С., Лихтер Р.А., Каипов А.Э. Оценка липосакции в структуре абдоминопластики и сочетанной герниоабдоминопластики. Креативная хирургия и онкология. 2023;13(4):278–83. DOI: 10.24060/2076-3093-2023-13-4-278-283","Dang Y., Du X., Ou X., Zheng Q., Xie F. Advances in diagnosis and treatment of Madelung’s deformity. Am J Transl Res. 2023;15(7):4416–24.","Leti Acciaro A, Garagnani L, Lando M, Lana D, Sartini S, Adani R. Modified dome osteotomy and anterior locking plate fixation for distal radius variant of Madelung deformity: a retrospective study. J Plast Surg Hand Surg. 2022;56(2):121–6. DOI: 10.1080/2000656X.2021.1934845"],"dc.identifier.uri":["http://hdl.handle.net/123456789/8932"],"dc.date.accessioned_dt":"2025-07-09T13:59:02Z","dc.date.accessioned":["2025-07-09T13:59:02Z"],"dc.date.available":["2025-07-09T13:59:02Z"],"publication_grp":["123456789/8932"],"bi_4_dis_filter":["madelung’s disease\n|||\nMadelung’s disease","lipectomy\n|||\nlipectomy","диффузный симметричный липоматоз\n|||\nдиффузный симметричный липоматоз","шеи новообразования\n|||\nшеи новообразования","липэктомия\n|||\nлипэктомия","diffuse symmetric lipomatosis\n|||\ndiffuse symmetric lipomatosis","adipose tissue proliferation\n|||\nadipose tissue proliferation","жировой ткани разрастание\n|||\nжировой ткани разрастание","болезнь маделунга\n|||\nболезнь Маделунга","neck neoplasms\n|||\nneck neoplasms"],"bi_4_dis_partial":["липэктомия","Madelung’s disease","diffuse symmetric lipomatosis","neck neoplasms","болезнь Маделунга","adipose tissue proliferation","шеи новообразования","lipectomy","диффузный симметричный липоматоз","жировой ткани разрастание"],"bi_4_dis_value_filter":["липэктомия","Madelung’s disease","diffuse symmetric lipomatosis","neck neoplasms","болезнь Маделунга","adipose tissue proliferation","шеи новообразования","lipectomy","диффузный симметричный липоматоз","жировой ткани разрастание"],"bi_sort_1_sort":"systemic benign lipomatosis (madelung’s disease): experience of surgical treatment. clinical case","bi_sort_3_sort":"2025-07-09T13:59:02Z","read":["g0"],"_version_":1837178072511545344},{"SolrIndexer.lastIndexed":"2022-02-16T07:30:36.259Z","search.uniqueid":"2-3923","search.resourcetype":2,"search.resourceid":3923,"handle":"123456789/4826","location":["m229","l684"],"location.comm":["229"],"location.coll":["684"],"withdrawn":"false","discoverable":"true","author":["Fengyu, Yin","Jin, Liu","Haima, Yang","Aleksey, Kudreyko","Bo, Huang"],"author_keyword":["Fengyu, Yin","Jin, Liu","Haima, Yang","Aleksey, Kudreyko","Bo, Huang"],"author_ac":["fengyu, yin\n|||\nFengyu, Yin","jin, liu\n|||\nJin, Liu","haima, yang\n|||\nHaima, Yang","aleksey, kudreyko\n|||\nAleksey, Kudreyko","bo, huang\n|||\nBo, Huang"],"author_filter":["fengyu, yin\n|||\nFengyu, Yin","jin, liu\n|||\nJin, Liu","haima, yang\n|||\nHaima, Yang","aleksey, kudreyko\n|||\nAleksey, Kudreyko","bo, huang\n|||\nBo, Huang"],"dc.contributor.author_hl":["Fengyu, Yin","Jin, Liu","Haima, Yang","Aleksey, Kudreyko","Bo, Huang"],"dc.contributor.author_mlt":["Fengyu, Yin","Jin, Liu","Haima, Yang","Aleksey, Kudreyko","Bo, Huang"],"dc.contributor.author":["Fengyu, Yin","Jin, Liu","Haima, Yang","Aleksey, Kudreyko","Bo, Huang"],"dc.contributor.author_stored":["Fengyu, Yin\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Jin, Liu\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Haima, Yang\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Aleksey, Kudreyko\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Bo, Huang\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen"],"dc.contributor.author.en":["Fengyu, Yin","Jin, Liu","Haima, Yang","Aleksey, Kudreyko","Bo, Huang"],"dc.date.accessioned_dt":"2020-12-02T09:09:23Z","dc.date.accessioned":["2020-12-02T09:09:23Z"],"dc.date.available":["2020-12-02T09:09:23Z"],"dateIssued":["2020-01-01"],"dateIssued_keyword":["2020-01-01","2020"],"dateIssued_ac":["2020-01-01\n|||\n2020-01-01","2020"],"dateIssued.year":[2020],"dateIssued.year_sort":"2020","dc.date.issued_dt":"2020-01-01T00:00:00Z","dc.date.issued":["2020-01-01"],"dc.date.issued_stored":["2020-01-01\n|||\nnull\n|||\nnull\n|||\nnull\n|||\n"],"dc.description.abstract_hl":["Surface Plasma resonance (SPR) sensors combined with biological receptors are widely used in biosensors. Due to limitations of measurement techniques, small-scale, low accuracy, and sensitivity to the refractive index of solution in traditional SPR prism sensor arise. As a consequence, it is difficult to launch commercial production of SPR sensors. The theory of localized surface plasmon resonance (LSPR) developed based on SPR theory has stronger coupling ability to near-field photons. Based on the LSPR sensing theory, we propose a submicron-sized golden-disk and graphene composite structure. By varying the thickness and diameter of the array disk, the performance of the LSPR sensor can be optimized. A graphene layer sandwiched between the golden-disk and the silver film can prevent the latter from oxidizing. Symmetrical design enables high-low concentration of dual-channel distributed sensing. As the fixed light source, we use a 632.8-nm laser. A golden nano-disk with 45 nm thickness and 70 nm radius is designed, using a finite difference time domain (FDTD) simulation system. When the incident angle is 42 degrees, the figure of merit (FOM) reaches 8826, and the measurable refractive index range reaches 0.2317."],"dc.description.abstract":["Surface Plasma resonance (SPR) sensors combined with biological receptors are widely used in biosensors. Due to limitations of measurement techniques, small-scale, low accuracy, and sensitivity to the refractive index of solution in traditional SPR prism sensor arise. As a consequence, it is difficult to launch commercial production of SPR sensors. The theory of localized surface plasmon resonance (LSPR) developed based on SPR theory has stronger coupling ability to near-field photons. Based on the LSPR sensing theory, we propose a submicron-sized golden-disk and graphene composite structure. By varying the thickness and diameter of the array disk, the performance of the LSPR sensor can be optimized. A graphene layer sandwiched between the golden-disk and the silver film can prevent the latter from oxidizing. Symmetrical design enables high-low concentration of dual-channel distributed sensing. As the fixed light source, we use a 632.8-nm laser. A golden nano-disk with 45 nm thickness and 70 nm radius is designed, using a finite difference time domain (FDTD) simulation system. When the incident angle is 42 degrees, the figure of merit (FOM) reaches 8826, and the measurable refractive index range reaches 0.2317."],"dc.description.abstract.en":["Surface Plasma resonance (SPR) sensors combined with biological receptors are widely used in biosensors. Due to limitations of measurement techniques, small-scale, low accuracy, and sensitivity to the refractive index of solution in traditional SPR prism sensor arise. As a consequence, it is difficult to launch commercial production of SPR sensors. The theory of localized surface plasmon resonance (LSPR) developed based on SPR theory has stronger coupling ability to near-field photons. Based on the LSPR sensing theory, we propose a submicron-sized golden-disk and graphene composite structure. By varying the thickness and diameter of the array disk, the performance of the LSPR sensor can be optimized. A graphene layer sandwiched between the golden-disk and the silver film can prevent the latter from oxidizing. Symmetrical design enables high-low concentration of dual-channel distributed sensing. As the fixed light source, we use a 632.8-nm laser. A golden nano-disk with 45 nm thickness and 70 nm radius is designed, using a finite difference time domain (FDTD) simulation system. When the incident angle is 42 degrees, the figure of merit (FOM) reaches 8826, and the measurable refractive index range reaches 0.2317."],"dc.doi":["10.3390/sym12050841"],"dc.doi.en":["10.3390/sym12050841"],"dc.identifier.issn":["2073-8994"],"dc.identifier.uri":["http://hdl.handle.net/123456789/4826"],"dc.identifier.uri.en":["http://hdl.handle.net/123456789/4826"],"dc.language.iso":["en"],"dc.language.iso.en":["en"],"dc.relation.ispartofseries":["SYMMETRY-BASEL;Том 12, № 5"],"dc.relation.ispartofseries.en":["SYMMETRY-BASEL;Том 12, № 5"],"subject":["LSPR","GRAPHENE","OPTICAL SENSOR","SUBMICRON STRUCTURES","Web of Science","Scopus"],"subject_keyword":["LSPR","LSPR","GRAPHENE","GRAPHENE","OPTICAL SENSOR","OPTICAL SENSOR","SUBMICRON STRUCTURES","SUBMICRON STRUCTURES","Web of Science","Web of Science","Scopus","Scopus"],"subject_ac":["lspr\n|||\nLSPR","graphene\n|||\nGRAPHENE","optical sensor\n|||\nOPTICAL SENSOR","submicron structures\n|||\nSUBMICRON STRUCTURES","web of science\n|||\nWeb of Science","scopus\n|||\nScopus"],"subject_tax_0_filter":["lspr\n|||\nLSPR","graphene\n|||\nGRAPHENE","optical sensor\n|||\nOPTICAL SENSOR","submicron structures\n|||\nSUBMICRON STRUCTURES","web of science\n|||\nWeb of Science","scopus\n|||\nScopus"],"subject_filter":["lspr\n|||\nLSPR","graphene\n|||\nGRAPHENE","optical sensor\n|||\nOPTICAL SENSOR","submicron structures\n|||\nSUBMICRON STRUCTURES","web of science\n|||\nWeb of Science","scopus\n|||\nScopus"],"dc.subject_mlt":["LSPR","GRAPHENE","OPTICAL SENSOR","SUBMICRON STRUCTURES","Web of Science","Scopus"],"dc.subject":["LSPR","GRAPHENE","OPTICAL SENSOR","SUBMICRON STRUCTURES","Web of Science","Scopus"],"dc.subject.en":["LSPR","GRAPHENE","OPTICAL SENSOR","SUBMICRON STRUCTURES","Web of Science","Scopus"],"title":["Design and Optimization of Plasmon Resonance Sensor Based on Micro-Nano Symmetrical Localized Surface"],"title_keyword":["Design and Optimization of Plasmon Resonance Sensor Based on Micro-Nano Symmetrical Localized Surface"],"title_ac":["design and optimization of plasmon resonance sensor based on micro-nano symmetrical localized surface\n|||\nDesign and Optimization of Plasmon Resonance Sensor Based on Micro-Nano Symmetrical Localized Surface"],"dc.title_sort":"Design and Optimization of Plasmon Resonance Sensor Based on Micro-Nano Symmetrical Localized Surface","dc.title_hl":["Design and Optimization of Plasmon Resonance Sensor Based on Micro-Nano Symmetrical Localized Surface"],"dc.title_mlt":["Design and Optimization of Plasmon Resonance Sensor Based on Micro-Nano Symmetrical Localized Surface"],"dc.title":["Design and Optimization of Plasmon Resonance Sensor Based on Micro-Nano Symmetrical Localized Surface"],"dc.title_stored":["Design and Optimization of Plasmon Resonance Sensor Based on Micro-Nano Symmetrical Localized Surface\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen"],"dc.title.en":["Design and Optimization of Plasmon Resonance Sensor Based on Micro-Nano Symmetrical Localized Surface"],"dc.title.alternative":["Design and Optimization of Plasmon Resonance Sensor Based on Micro-Nano Symmetrical Localized Surface"],"dc.title.alternative.en":["Design and Optimization of Plasmon Resonance Sensor Based on Micro-Nano Symmetrical Localized Surface"],"dc.type":["Article"],"dc.type.en":["Article"],"publication_grp":["123456789/4826"],"bi_2_dis_filter":["aleksey, kudreyko\n|||\nAleksey, Kudreyko","fengyu, yin\n|||\nFengyu, Yin","bo, huang\n|||\nBo, Huang","haima, yang\n|||\nHaima, Yang","jin, liu\n|||\nJin, Liu"],"bi_2_dis_partial":["Jin, Liu","Aleksey, Kudreyko","Bo, Huang","Fengyu, Yin","Haima, Yang"],"bi_2_dis_value_filter":["Jin, Liu","Aleksey, Kudreyko","Bo, Huang","Fengyu, Yin","Haima, Yang"],"bi_4_dis_filter":["graphene\n|||\nGRAPHENE","submicron structures\n|||\nSUBMICRON STRUCTURES","lspr\n|||\nLSPR","scopus\n|||\nScopus","optical sensor\n|||\nOPTICAL SENSOR","web of science\n|||\nWeb of Science"],"bi_4_dis_partial":["SUBMICRON STRUCTURES","Web of Science","OPTICAL SENSOR","Scopus","GRAPHENE","LSPR"],"bi_4_dis_value_filter":["SUBMICRON STRUCTURES","Web of Science","OPTICAL SENSOR","Scopus","GRAPHENE","LSPR"],"bi_sort_1_sort":"design and optimization of plasmon resonance sensor based on micro-nano symmetrical localized surface","bi_sort_2_sort":"2020","bi_sort_3_sort":"2020-12-02T09:09:23Z","read":["g0"],"_version_":1724903992870305792},{"SolrIndexer.lastIndexed":"2024-04-26T07:10:33.566Z","search.uniqueid":"2-7244","search.resourcetype":2,"search.resourceid":7244,"handle":"123456789/8121","location":["m229","l684"],"location.comm":["229"],"location.coll":["684"],"withdrawn":"false","discoverable":"true","author":["Leonov, K.V.","Akhatov, I. Sh."],"author_keyword":["Leonov, K.V.","Akhatov, I. Sh."],"author_ac":["leonov, k.v.\n|||\nLeonov, K.V.","akhatov, i. sh.\n|||\nAkhatov, I. Sh."],"author_filter":["leonov, k.v.\n|||\nLeonov, K.V.","akhatov, i. sh.\n|||\nAkhatov, I. Sh."],"dc.contributor.author_hl":["Leonov, K.V.","Akhatov, I. Sh."],"dc.contributor.author_mlt":["Leonov, K.V.","Akhatov, I. Sh."],"dc.contributor.author":["Leonov, K.V.","Akhatov, I. Sh."],"dc.contributor.author_stored":["Leonov, K.V.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Akhatov, I. Sh.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen"],"dc.contributor.author.en":["Leonov, K.V.","Akhatov, I. Sh."],"dc.date.accessioned_dt":"2024-04-26T07:09:41Z","dc.date.accessioned":["2024-04-26T07:09:41Z"],"dc.date.available":["2024-04-26T07:09:41Z"],"dateIssued":["2024-01-01"],"dateIssued_keyword":["2024-01-01","2024"],"dateIssued_ac":["2024-01-01\n|||\n2024-01-01","2024"],"dateIssued.year":[2024],"dateIssued.year_sort":"2024","dc.date.issued_dt":"2024-01-01T00:00:00Z","dc.date.issued":["2024-01-01"],"dc.date.issued_stored":["2024-01-01\n|||\nnull\n|||\nnull\n|||\nnull\n|||\n"],"dc.description.abstract_hl":["Abstract: The diffusion stability of a single cavitation bubble in a spherical liquid cell surrounded by an infinite elastic solid is considered. The time-periodic pressure in the solid far away from the liquid cell is used as an external driving, which initiates bubble oscillations along with the gas diffusion process in the bubble-in-cell system. The work is based on the engineering approximation according to which the bubble growth/reduction is considered on average, assuming that during the period of the external driving the mass of gas in the bubble does not noticeably change. This theory predicts the existence of stably oscillating bubbles in confined liquid undergoing an external driving force. Three possible diffusion regimes are revealed: 1) total bubble dissolution, 2) partial bubble dissolution, and 3) partial bubble growth, where the last two regimes provide the diffusion stability in the bubble-in-cell system. The parametric study of the influence of the gas concentration dissolved in the liquid on the resulting stable bubble size is conducted. The obtained results are compared with the results for the case of the stable bubble oscillations in the pressure sound field in a bulk (infinite) liquid. The theoretical findings of the present study can be used for improvement of the modern applications of ultrasound technology. © Pleiades Publishing, Ltd. 2024. ISSN 0015-4628, Fluid Dynamics, 2024, Vol. 59, No. 1, pp. 60–73. Pleiades Publishing, Ltd., 2024."],"dc.description.abstract":["Abstract: The diffusion stability of a single cavitation bubble in a spherical liquid cell surrounded by an infinite elastic solid is considered. The time-periodic pressure in the solid far away from the liquid cell is used as an external driving, which initiates bubble oscillations along with the gas diffusion process in the bubble-in-cell system. The work is based on the engineering approximation according to which the bubble growth/reduction is considered on average, assuming that during the period of the external driving the mass of gas in the bubble does not noticeably change. This theory predicts the existence of stably oscillating bubbles in confined liquid undergoing an external driving force. Three possible diffusion regimes are revealed: 1) total bubble dissolution, 2) partial bubble dissolution, and 3) partial bubble growth, where the last two regimes provide the diffusion stability in the bubble-in-cell system. The parametric study of the influence of the gas concentration dissolved in the liquid on the resulting stable bubble size is conducted. The obtained results are compared with the results for the case of the stable bubble oscillations in the pressure sound field in a bulk (infinite) liquid. The theoretical findings of the present study can be used for improvement of the modern applications of ultrasound technology. © Pleiades Publishing, Ltd. 2024. ISSN 0015-4628, Fluid Dynamics, 2024, Vol. 59, No. 1, pp. 60–73. Pleiades Publishing, Ltd., 2024."],"dc.description.abstract.en":["Abstract: The diffusion stability of a single cavitation bubble in a spherical liquid cell surrounded by an infinite elastic solid is considered. The time-periodic pressure in the solid far away from the liquid cell is used as an external driving, which initiates bubble oscillations along with the gas diffusion process in the bubble-in-cell system. The work is based on the engineering approximation according to which the bubble growth/reduction is considered on average, assuming that during the period of the external driving the mass of gas in the bubble does not noticeably change. This theory predicts the existence of stably oscillating bubbles in confined liquid undergoing an external driving force. Three possible diffusion regimes are revealed: 1) total bubble dissolution, 2) partial bubble dissolution, and 3) partial bubble growth, where the last two regimes provide the diffusion stability in the bubble-in-cell system. The parametric study of the influence of the gas concentration dissolved in the liquid on the resulting stable bubble size is conducted. The obtained results are compared with the results for the case of the stable bubble oscillations in the pressure sound field in a bulk (infinite) liquid. The theoretical findings of the present study can be used for improvement of the modern applications of ultrasound technology. © Pleiades Publishing, Ltd. 2024. ISSN 0015-4628, Fluid Dynamics, 2024, Vol. 59, No. 1, pp. 60–73. Pleiades Publishing, Ltd., 2024."],"dc.doi":["10.1134/S0015462823602413"],"dc.identifier.issn":["0015-4628"],"dc.identifier.uri":["http://hdl.handle.net/123456789/8121"],"dc.language.iso":["en"],"dc.language.iso.en":["en"],"dc.relation.ispartofseries":["Fluid Dynamics;v. 59 № 1"],"dc.relation.ispartofseries.en":["Fluid Dynamics;v. 59 № 1"],"subject":["bubble dynamics","cavitation","diffusion","ultrasound","Scopus"],"subject_keyword":["bubble dynamics","bubble dynamics","cavitation","cavitation","diffusion","diffusion","ultrasound","ultrasound","Scopus","Scopus"],"subject_ac":["bubble dynamics\n|||\nbubble dynamics","cavitation\n|||\ncavitation","diffusion\n|||\ndiffusion","ultrasound\n|||\nultrasound","scopus\n|||\nScopus"],"subject_tax_0_filter":["bubble dynamics\n|||\nbubble dynamics","cavitation\n|||\ncavitation","diffusion\n|||\ndiffusion","ultrasound\n|||\nultrasound","scopus\n|||\nScopus"],"subject_filter":["bubble dynamics\n|||\nbubble dynamics","cavitation\n|||\ncavitation","diffusion\n|||\ndiffusion","ultrasound\n|||\nultrasound","scopus\n|||\nScopus"],"dc.subject_mlt":["bubble dynamics","cavitation","diffusion","ultrasound","Scopus"],"dc.subject":["bubble dynamics","cavitation","diffusion","ultrasound","Scopus"],"dc.subject.en":["bubble dynamics","cavitation","diffusion","ultrasound","Scopus"],"title":["The Diffusion Stability of an Externally Driven Cavitation Bubble in Micro-Confinement"],"title_keyword":["The Diffusion Stability of an Externally Driven Cavitation Bubble in Micro-Confinement"],"title_ac":["the diffusion stability of an externally driven cavitation bubble in micro-confinement\n|||\nThe Diffusion Stability of an Externally Driven Cavitation Bubble in Micro-Confinement"],"dc.title_sort":"The Diffusion Stability of an Externally Driven Cavitation Bubble in Micro-Confinement","dc.title_hl":["The Diffusion Stability of an Externally Driven Cavitation Bubble in Micro-Confinement"],"dc.title_mlt":["The Diffusion Stability of an Externally Driven Cavitation Bubble in Micro-Confinement"],"dc.title":["The Diffusion Stability of an Externally Driven Cavitation Bubble in Micro-Confinement"],"dc.title_stored":["The Diffusion Stability of an Externally Driven Cavitation Bubble in Micro-Confinement\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen"],"dc.title.en":["The Diffusion Stability of an Externally Driven Cavitation Bubble in Micro-Confinement"],"dc.title.alternative":["The Diffusion Stability of an Externally Driven Cavitation Bubble in Micro-Confinement"],"dc.title.alternative.en":["The Diffusion Stability of an Externally Driven Cavitation Bubble in Micro-Confinement"],"dc.type":["Article"],"dc.type.en":["Article"],"publication_grp":["123456789/8121"],"bi_2_dis_filter":["leonov, k.v.\n|||\nLeonov, K.V.","akhatov, i. sh.\n|||\nAkhatov, I. Sh."],"bi_2_dis_partial":["Akhatov, I. Sh.","Leonov, K.V."],"bi_2_dis_value_filter":["Akhatov, I. Sh.","Leonov, K.V."],"bi_4_dis_filter":["cavitation\n|||\ncavitation","ultrasound\n|||\nultrasound","bubble dynamics\n|||\nbubble dynamics","diffusion\n|||\ndiffusion","scopus\n|||\nScopus"],"bi_4_dis_partial":["diffusion","Scopus","bubble dynamics","ultrasound","cavitation"],"bi_4_dis_value_filter":["diffusion","Scopus","bubble dynamics","ultrasound","cavitation"],"bi_sort_1_sort":"diffusion stability of an externally driven cavitation bubble in micro-confinement","bi_sort_2_sort":"2024","bi_sort_3_sort":"2024-04-26T07:09:41Z","read":["g0"],"_version_":1797380304911990784},{"SolrIndexer.lastIndexed":"2022-09-21T06:31:44.496Z","search.uniqueid":"2-6022","search.resourcetype":2,"search.resourceid":6022,"handle":"123456789/6927","location":["m229","l684"],"location.comm":["229"],"location.coll":["684"],"withdrawn":"false","discoverable":"true","dc.abstract":["Neurofibromatosis type 1 is the most common autosomal dominant tumor syndrome. The prevalence of the disease is 1 in 3000 people. Neurofibromatosis type 1 is characterized by the gradual appearance of signs of the disease and pronounced clinical polymorphism from erased and atypical forms to severe classical manifestations. The review is devoted to the consideration of diseases, the manifestations of which are significantly similar to neurofibromatosis type 1, and therefore, molecular diagnosis of the disease is an important method for differential diagnosis. To make a diagnosis of neurofibromatosis type 1, it is necessary to find mutations in the NF1 gene using sequencing. In 10% of cases, neurofibromatosis type 1 is caused by large deletions of the 17q11.2 locus, therefore, multiplex ligation-dependent probe amplification is also necessary. Typically, the initial manifestations of neurofibromatosis type 1 are multiple café-au-lait spots, which may be the only external signs of the disease for many years. Therefore, patients with neurofibromatosis type 1 may be mistakenly diagnosed with diseases for which these pigmentary changes are characteristic: Bloom, LEOPARD, Carney, Costello, Cowden, Legius, Nijmegen, Noonan, Peitz-Jägers, Silver-Russell, cardio-facio-cutaneous syndromes. The detection of subcutaneous tumors can become the basis for an incorrect diagnosis of the clinically similar Legius syndrome and multiple endocrine neoplasia. In addition, multiple lipomas are specific manifestations of Madelung or Dercum lipomatosis, familial angiolipomatosis, the etiology of which is considered unknown. Therefore, I assume that these diseases are atypical forms of neurofibromatosis type 1, since a number of authors have described the identification of mutations in NF1 gene in patients with multiple lipomatosis. Therefore, it is important to widely introduce into clinical practice the possibility of molecular genetic identification of the disease in order to identify cases of neurofibromatosis type 1 that do not meet the diagnostic criteria adopted by the NIH. It is promising to create a panel for the study of all genes, mutations in which can cause manifestations similar to neurofibromatosis. Early diagnosis of the disease is necessary for timely initiation of treatment and prevention of severe manifestations, since effective methods of antitumor therapy of neurofibromatosis type 1, such as inhibitors of mitogen-activated kinase, are being introduced into clinical practice. © 2022 Tomsk State University. All rights reserved."],"dc.abstract.en":["Neurofibromatosis type 1 is the most common autosomal dominant tumor syndrome. The prevalence of the disease is 1 in 3000 people. Neurofibromatosis type 1 is characterized by the gradual appearance of signs of the disease and pronounced clinical polymorphism from erased and atypical forms to severe classical manifestations. The review is devoted to the consideration of diseases, the manifestations of which are significantly similar to neurofibromatosis type 1, and therefore, molecular diagnosis of the disease is an important method for differential diagnosis. To make a diagnosis of neurofibromatosis type 1, it is necessary to find mutations in the NF1 gene using sequencing. In 10% of cases, neurofibromatosis type 1 is caused by large deletions of the 17q11.2 locus, therefore, multiplex ligation-dependent probe amplification is also necessary. Typically, the initial manifestations of neurofibromatosis type 1 are multiple café-au-lait spots, which may be the only external signs of the disease for many years. Therefore, patients with neurofibromatosis type 1 may be mistakenly diagnosed with diseases for which these pigmentary changes are characteristic: Bloom, LEOPARD, Carney, Costello, Cowden, Legius, Nijmegen, Noonan, Peitz-Jägers, Silver-Russell, cardio-facio-cutaneous syndromes. The detection of subcutaneous tumors can become the basis for an incorrect diagnosis of the clinically similar Legius syndrome and multiple endocrine neoplasia. In addition, multiple lipomas are specific manifestations of Madelung or Dercum lipomatosis, familial angiolipomatosis, the etiology of which is considered unknown. Therefore, I assume that these diseases are atypical forms of neurofibromatosis type 1, since a number of authors have described the identification of mutations in NF1 gene in patients with multiple lipomatosis. Therefore, it is important to widely introduce into clinical practice the possibility of molecular genetic identification of the disease in order to identify cases of neurofibromatosis type 1 that do not meet the diagnostic criteria adopted by the NIH. It is promising to create a panel for the study of all genes, mutations in which can cause manifestations similar to neurofibromatosis. Early diagnosis of the disease is necessary for timely initiation of treatment and prevention of severe manifestations, since effective methods of antitumor therapy of neurofibromatosis type 1, such as inhibitors of mitogen-activated kinase, are being introduced into clinical practice. © 2022 Tomsk State University. All rights reserved."],"author":["Mustafin, R.N.","Мустафин, Р.Н."],"author_keyword":["Mustafin, R.N.","Мустафин, Р.Н."],"author_ac":["mustafin, r.n.\n|||\nMustafin, R.N.","мустафин, р.н.\n|||\nМустафин, Р.Н."],"author_filter":["mustafin, r.n.\n|||\nMustafin, R.N.","мустафин, р.н.\n|||\nМустафин, Р.Н."],"dc.contributor.author_hl":["Mustafin, R.N.","Мустафин, Р.Н."],"dc.contributor.author_mlt":["Mustafin, R.N.","Мустафин, Р.Н."],"dc.contributor.author":["Mustafin, R.N.","Мустафин, Р.Н."],"dc.contributor.author_stored":["Mustafin, R.N.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Мустафин, Р.Н.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nru_RU"],"dc.contributor.author.en":["Mustafin, R.N."],"dc.contributor.author.ru_RU":["Мустафин, Р.Н."],"dc.date.accessioned_dt":"2022-09-21T06:30:21Z","dc.date.accessioned":["2022-09-21T06:30:21Z"],"dc.date.available":["2022-09-21T06:30:21Z"],"dateIssued":["2022-01-01"],"dateIssued_keyword":["2022-01-01","2022"],"dateIssued_ac":["2022-01-01\n|||\n2022-01-01","2022"],"dateIssued.year":[2022],"dateIssued.year_sort":"2022","dc.date.issued_dt":"2022-01-01T00:00:00Z","dc.date.issued":["2022-01-01"],"dc.date.issued_stored":["2022-01-01\n|||\nnull\n|||\nnull\n|||\nnull\n|||\n"],"dc.description.abstract_hl":["Нейрофиброматоз 1-го типа является самым распространенным аутосомно-доминантным опухолевым синдромом, встречающимся с частот ой 1 на 3000 населения. Особенностью клинических проявлений болезни является постепенное появление признаков и выраженный клинический полиморфизм от стертых и атипичных форм до тяжелых классических проявлений. В данном обзоре рассмотрены заболевания,\nсимптомы которых значительно схожи с нейрофиброматозом 1-го типа, в связи с чем важным методом для дифференциальной диагностики\nявляется молекулярная диагностика болезни. Поскольку 10% случаев заболевания обусловлены крупными делециями локуса 17q11.2, помимо секвенирования гена NF1 необходимо проведение зависимой от лигирования мультиплексной амплификации зонда. В большинстве случаев начальными проявлениями нейрофиброматоза 1-го типа являются множественные пигментные пятна, которые на протяжении многих\nлет могут быть единственными внешними признаками болезни. В связи с этим могут быть ошибочно установлены диагнозы, для которых характерны данные пигментные изменения: синдромы Блума, LEOPARD, Карнея, Костелло, Коудена, Легиуса, Ниймеген, Нунан, Пейтца-Егерса,\nСильвера-Рассела, кардио-фацио-кожный синдром. Обнаружение подкожных нейрофибром может стать основанием для неверной диагностики схожих по клинике синдромов Легиуса и множественной эндокринной неоплазии. Кроме того, множественные липомы являются специфическими проявлениями липоматозов Маделунга или Деркума, семейного ангиолипоматоза, этиология которых считается неизвестной.\nСделано предположение, что эти заболевания являются атипичными формами нейрофиброматоза 1-го типа, поскольку ряд авторов описали идентификацию мутаций в гене NF1 у пациентов со множественным липоматозом. Поэтому важное значение имеет широкое внедрение в клиническую практику возможности молекулярно-генетической идентификации болезни для выявления случаев нейрофиброматоза\n1-го типа, не соответствующих принятым NIH (National Institute of Health) критериям диагностики. Наиболее перспективно создание панели\nс исследованием всех генов, мутации в которых могут вызывать схожие с нейрофиброматозом 1-го типа проявления. Ранняя диагностика\nзаболевания необходима для своевременного начала лечения и предотвращения тяжелых проявлений, поскольку в клиническую практику\nвнедряются эффективные методы противоопухолевой терапии, такие как ингибиторы митоген-активируемой киназы"],"dc.description.abstract":["Нейрофиброматоз 1-го типа является самым распространенным аутосомно-доминантным опухолевым синдромом, встречающимся с частот ой 1 на 3000 населения. Особенностью клинических проявлений болезни является постепенное появление признаков и выраженный клинический полиморфизм от стертых и атипичных форм до тяжелых классических проявлений. В данном обзоре рассмотрены заболевания,\nсимптомы которых значительно схожи с нейрофиброматозом 1-го типа, в связи с чем важным методом для дифференциальной диагностики\nявляется молекулярная диагностика болезни. Поскольку 10% случаев заболевания обусловлены крупными делециями локуса 17q11.2, помимо секвенирования гена NF1 необходимо проведение зависимой от лигирования мультиплексной амплификации зонда. В большинстве случаев начальными проявлениями нейрофиброматоза 1-го типа являются множественные пигментные пятна, которые на протяжении многих\nлет могут быть единственными внешними признаками болезни. В связи с этим могут быть ошибочно установлены диагнозы, для которых характерны данные пигментные изменения: синдромы Блума, LEOPARD, Карнея, Костелло, Коудена, Легиуса, Ниймеген, Нунан, Пейтца-Егерса,\nСильвера-Рассела, кардио-фацио-кожный синдром. Обнаружение подкожных нейрофибром может стать основанием для неверной диагностики схожих по клинике синдромов Легиуса и множественной эндокринной неоплазии. Кроме того, множественные липомы являются специфическими проявлениями липоматозов Маделунга или Деркума, семейного ангиолипоматоза, этиология которых считается неизвестной.\nСделано предположение, что эти заболевания являются атипичными формами нейрофиброматоза 1-го типа, поскольку ряд авторов описали идентификацию мутаций в гене NF1 у пациентов со множественным липоматозом. Поэтому важное значение имеет широкое внедрение в клиническую практику возможности молекулярно-генетической идентификации болезни для выявления случаев нейрофиброматоза\n1-го типа, не соответствующих принятым NIH (National Institute of Health) критериям диагностики. Наиболее перспективно создание панели\nс исследованием всех генов, мутации в которых могут вызывать схожие с нейрофиброматозом 1-го типа проявления. Ранняя диагностика\nзаболевания необходима для своевременного начала лечения и предотвращения тяжелых проявлений, поскольку в клиническую практику\nвнедряются эффективные методы противоопухолевой терапии, такие как ингибиторы митоген-активируемой киназы"],"dc.description.abstract.ru_RU":["Нейрофиброматоз 1-го типа является самым распространенным аутосомно-доминантным опухолевым синдромом, встречающимся с частот ой 1 на 3000 населения. Особенностью клинических проявлений болезни является постепенное появление признаков и выраженный клинический полиморфизм от стертых и атипичных форм до тяжелых классических проявлений. В данном обзоре рассмотрены заболевания,\nсимптомы которых значительно схожи с нейрофиброматозом 1-го типа, в связи с чем важным методом для дифференциальной диагностики\nявляется молекулярная диагностика болезни. Поскольку 10% случаев заболевания обусловлены крупными делециями локуса 17q11.2, помимо секвенирования гена NF1 необходимо проведение зависимой от лигирования мультиплексной амплификации зонда. В большинстве случаев начальными проявлениями нейрофиброматоза 1-го типа являются множественные пигментные пятна, которые на протяжении многих\nлет могут быть единственными внешними признаками болезни. В связи с этим могут быть ошибочно установлены диагнозы, для которых характерны данные пигментные изменения: синдромы Блума, LEOPARD, Карнея, Костелло, Коудена, Легиуса, Ниймеген, Нунан, Пейтца-Егерса,\nСильвера-Рассела, кардио-фацио-кожный синдром. Обнаружение подкожных нейрофибром может стать основанием для неверной диагностики схожих по клинике синдромов Легиуса и множественной эндокринной неоплазии. Кроме того, множественные липомы являются специфическими проявлениями липоматозов Маделунга или Деркума, семейного ангиолипоматоза, этиология которых считается неизвестной.\nСделано предположение, что эти заболевания являются атипичными формами нейрофиброматоза 1-го типа, поскольку ряд авторов описали идентификацию мутаций в гене NF1 у пациентов со множественным липоматозом. Поэтому важное значение имеет широкое внедрение в клиническую практику возможности молекулярно-генетической идентификации болезни для выявления случаев нейрофиброматоза\n1-го типа, не соответствующих принятым NIH (National Institute of Health) критериям диагностики. Наиболее перспективно создание панели\nс исследованием всех генов, мутации в которых могут вызывать схожие с нейрофиброматозом 1-го типа проявления. Ранняя диагностика\nзаболевания необходима для своевременного начала лечения и предотвращения тяжелых проявлений, поскольку в клиническую практику\nвнедряются эффективные методы противоопухолевой терапии, такие как ингибиторы митоген-активируемой киназы"],"dc.doi":["10.20514/2226-6704-2021-12-2-93-103"],"dc.identifier.issn":["2226-6704"],"dc.identifier.uri":["http://hdl.handle.net/123456789/6927"],"dc.publisher":["SINAPS LLC"],"dc.publisher.en":["SINAPS LLC"],"dc.relation.ispartofseries":["Russian Archives of Internal Medicine;т. 12 № 2"],"dc.relation.ispartofseries.en":["Russian Archives of Internal Medicine;т. 12 № 2"],"subject":["ген NF1","дифференциальная диагностика","липоматоз","мутации","нейрофиброматоз 1-го типа","секвенирование","Scopus","differential diagnosis","lipomatosis","mutations","neurofibromatosis type 1","NF1 gene","sequencing"],"subject_keyword":["ген NF1","ген NF1","дифференциальная диагностика","дифференциальная диагностика","липоматоз","липоматоз","мутации","мутации","нейрофиброматоз 1-го типа","нейрофиброматоз 1-го типа","секвенирование","секвенирование","Scopus","Scopus","differential diagnosis","differential diagnosis","lipomatosis","lipomatosis","mutations","mutations","neurofibromatosis type 1","neurofibromatosis type 1","NF1 gene","NF1 gene","sequencing","sequencing"],"subject_ac":["ген nf1\n|||\nген NF1","дифференциальная диагностика\n|||\nдифференциальная диагностика","липоматоз\n|||\nлипоматоз","мутации\n|||\nмутации","нейрофиброматоз 1-го типа\n|||\nнейрофиброматоз 1-го типа","секвенирование\n|||\nсеквенирование","scopus\n|||\nScopus","differential diagnosis\n|||\ndifferential diagnosis","lipomatosis\n|||\nlipomatosis","mutations\n|||\nmutations","neurofibromatosis type 1\n|||\nneurofibromatosis type 1","nf1 gene\n|||\nNF1 gene","sequencing\n|||\nsequencing"],"subject_tax_0_filter":["ген nf1\n|||\nген NF1","дифференциальная диагностика\n|||\nдифференциальная диагностика","липоматоз\n|||\nлипоматоз","мутации\n|||\nмутации","нейрофиброматоз 1-го типа\n|||\nнейрофиброматоз 1-го типа","секвенирование\n|||\nсеквенирование","scopus\n|||\nScopus","differential diagnosis\n|||\ndifferential diagnosis","lipomatosis\n|||\nlipomatosis","mutations\n|||\nmutations","neurofibromatosis type 1\n|||\nneurofibromatosis type 1","nf1 gene\n|||\nNF1 gene","sequencing\n|||\nsequencing"],"subject_filter":["ген nf1\n|||\nген NF1","дифференциальная диагностика\n|||\nдифференциальная диагностика","липоматоз\n|||\nлипоматоз","мутации\n|||\nмутации","нейрофиброматоз 1-го типа\n|||\nнейрофиброматоз 1-го типа","секвенирование\n|||\nсеквенирование","scopus\n|||\nScopus","differential diagnosis\n|||\ndifferential diagnosis","lipomatosis\n|||\nlipomatosis","mutations\n|||\nmutations","neurofibromatosis type 1\n|||\nneurofibromatosis type 1","nf1 gene\n|||\nNF1 gene","sequencing\n|||\nsequencing"],"dc.subject_mlt":["ген NF1","дифференциальная диагностика","липоматоз","мутации","нейрофиброматоз 1-го типа","секвенирование","Scopus","differential diagnosis","lipomatosis","mutations","neurofibromatosis type 1","NF1 gene","sequencing"],"dc.subject":["ген NF1","дифференциальная диагностика","липоматоз","мутации","нейрофиброматоз 1-го типа","секвенирование","Scopus","differential diagnosis","lipomatosis","mutations","neurofibromatosis type 1","NF1 gene","sequencing"],"dc.subject.ru_RU":["ген NF1","дифференциальная диагностика","липоматоз","мутации","нейрофиброматоз 1-го типа","секвенирование"],"dc.subject.en":["Scopus","differential diagnosis","lipomatosis","mutations","neurofibromatosis type 1","NF1 gene","sequencing"],"title":["Clinical Masks of Neurofibromatosis Type 1"],"title_keyword":["Clinical Masks of Neurofibromatosis Type 1"],"title_ac":["clinical masks of neurofibromatosis type 1\n|||\nClinical Masks of Neurofibromatosis Type 1"],"dc.title_sort":"Clinical Masks of Neurofibromatosis Type 1","dc.title_hl":["Clinical Masks of Neurofibromatosis Type 1"],"dc.title_mlt":["Clinical Masks of Neurofibromatosis Type 1"],"dc.title":["Clinical Masks of Neurofibromatosis Type 1"],"dc.title_stored":["Clinical Masks of Neurofibromatosis Type 1\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen"],"dc.title.en":["Clinical Masks of Neurofibromatosis Type 1"],"dc.title.alternative":["КЛИНИЧЕСКИЕ МАСКИ НЕЙРОФИБРОМАТОЗА 1-ГО ТИПА"],"dc.title.alternative.ru_RU":["КЛИНИЧЕСКИЕ МАСКИ НЕЙРОФИБРОМАТОЗА 1-ГО ТИПА"],"dc.type":["Article"],"dc.type.ru_RU":["Article"],"publication_grp":["123456789/6927"],"bi_2_dis_filter":["mustafin, r.n.\n|||\nMustafin, R.N.","мустафин, р.н.\n|||\nМустафин, Р.Н."],"bi_2_dis_partial":["Mustafin, R.N.","Мустафин, Р.Н."],"bi_2_dis_value_filter":["Mustafin, R.N.","Мустафин, Р.Н."],"bi_4_dis_filter":["секвенирование\n|||\nсеквенирование","mutations\n|||\nmutations","scopus\n|||\nScopus","мутации\n|||\nмутации","ген nf1\n|||\nген NF1","дифференциальная диагностика\n|||\nдифференциальная диагностика","nf1 gene\n|||\nNF1 gene","lipomatosis\n|||\nlipomatosis","липоматоз\n|||\nлипоматоз","sequencing\n|||\nsequencing","differential diagnosis\n|||\ndifferential diagnosis","neurofibromatosis type 1\n|||\nneurofibromatosis type 1","нейрофиброматоз 1-го типа\n|||\nнейрофиброматоз 1-го типа"],"bi_4_dis_partial":["differential diagnosis","мутации","lipomatosis","Scopus","секвенирование","sequencing","ген NF1","mutations","липоматоз","neurofibromatosis type 1","дифференциальная диагностика","нейрофиброматоз 1-го типа","NF1 gene"],"bi_4_dis_value_filter":["differential diagnosis","мутации","lipomatosis","Scopus","секвенирование","sequencing","ген NF1","mutations","липоматоз","neurofibromatosis type 1","дифференциальная диагностика","нейрофиброматоз 1-го типа","NF1 gene"],"bi_sort_1_sort":"clinical masks of neurofibromatosis type 1","bi_sort_2_sort":"2022","bi_sort_3_sort":"2022-09-21T06:30:21Z","read":["g0"],"_version_":1744559831260332032},{"SolrIndexer.lastIndexed":"2022-04-15T10:27:50.842Z","search.uniqueid":"2-5665","search.resourcetype":2,"search.resourceid":5665,"handle":"123456789/6570","location":["m229","l684"],"location.comm":["229"],"location.coll":["684"],"withdrawn":"false","discoverable":"true","author":["Abushahmina, GR","Gusarova, NI","Yumagulov, MG"],"author_keyword":["Abushahmina, GR","Gusarova, NI","Yumagulov, MG"],"author_ac":["abushahmina, gr\n|||\nAbushahmina, GR","gusarova, ni\n|||\nGusarova, NI","yumagulov, mg\n|||\nYumagulov, MG"],"author_filter":["abushahmina, gr\n|||\nAbushahmina, GR","gusarova, ni\n|||\nGusarova, NI","yumagulov, mg\n|||\nYumagulov, MG"],"dc.contributor.author_hl":["Abushahmina, GR","Gusarova, NI","Yumagulov, MG"],"dc.contributor.author_mlt":["Abushahmina, GR","Gusarova, NI","Yumagulov, MG"],"dc.contributor.author":["Abushahmina, GR","Gusarova, NI","Yumagulov, MG"],"dc.contributor.author_stored":["Abushahmina, GR\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Gusarova, NI\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Yumagulov, MG\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen"],"dc.contributor.author.en":["Abushahmina, GR","Gusarova, NI","Yumagulov, MG"],"dc.date.accessioned_dt":"2022-04-15T09:38:34Z","dc.date.accessioned":["2022-04-15T09:38:34Z"],"dc.date.available":["2022-04-15T09:38:34Z"],"dateIssued":["2021-01-01"],"dateIssued_keyword":["2021-01-01","2021"],"dateIssued_ac":["2021-01-01\n|||\n2021-01-01","2021"],"dateIssued.year":[2021],"dateIssued.year_sort":"2021","dc.date.issued_dt":"2021-01-01T00:00:00Z","dc.date.issued":["2021-01-01"],"dc.date.issued_stored":["2021-01-01\n|||\nnull\n|||\nnull\n|||\nnull\n|||\n"],"dc.description.abstract_hl":["The problem of the first Lyapunov quantity constructing on the Andronov-Hopf bifurcation problem in infinite-dimensional dynamical systems is considered. A general scheme of obtaining new formulas for the Lyapunov quantity in terms of the original equations is proposed. The ''reaction-diffusion'' equation in a limited region and in a situation when there are no flows of reacting components across the boundary of the region is considered as the main object of research. For this equation, the Andronov-Hopf bifurcation conditions in the vicinity of a spatially homogeneous equilibrium point are obtained, necessary conditions for the stability of emerging solutions are specified. New formulas for the first Lyapunov quantities and transcriticity indices of the problem, leading to algorithms for constructing these quantities are proposed. The specifics of these formulas are indicated in the situation when the nonlinearity begins with cubic terms. The proposed formulas make it possible not only to efficiently calculate the Lyapunov quantities, but also to conduct a study of the properties of bifurcations in reaction-diffusion systems under new conditions."],"dc.description.abstract":["The problem of the first Lyapunov quantity constructing on the Andronov-Hopf bifurcation problem in infinite-dimensional dynamical systems is considered. A general scheme of obtaining new formulas for the Lyapunov quantity in terms of the original equations is proposed. The ''reaction-diffusion'' equation in a limited region and in a situation when there are no flows of reacting components across the boundary of the region is considered as the main object of research. For this equation, the Andronov-Hopf bifurcation conditions in the vicinity of a spatially homogeneous equilibrium point are obtained, necessary conditions for the stability of emerging solutions are specified. New formulas for the first Lyapunov quantities and transcriticity indices of the problem, leading to algorithms for constructing these quantities are proposed. The specifics of these formulas are indicated in the situation when the nonlinearity begins with cubic terms. The proposed formulas make it possible not only to efficiently calculate the Lyapunov quantities, but also to conduct a study of the properties of bifurcations in reaction-diffusion systems under new conditions."],"dc.description.abstract.en":["The problem of the first Lyapunov quantity constructing on the Andronov-Hopf bifurcation problem in infinite-dimensional dynamical systems is considered. A general scheme of obtaining new formulas for the Lyapunov quantity in terms of the original equations is proposed. The ''reaction-diffusion'' equation in a limited region and in a situation when there are no flows of reacting components across the boundary of the region is considered as the main object of research. For this equation, the Andronov-Hopf bifurcation conditions in the vicinity of a spatially homogeneous equilibrium point are obtained, necessary conditions for the stability of emerging solutions are specified. New formulas for the first Lyapunov quantities and transcriticity indices of the problem, leading to algorithms for constructing these quantities are proposed. The specifics of these formulas are indicated in the situation when the nonlinearity begins with cubic terms. The proposed formulas make it possible not only to efficiently calculate the Lyapunov quantities, but also to conduct a study of the properties of bifurcations in reaction-diffusion systems under new conditions."],"dc.doi":["10.1134/S1995080222030027"],"dc.doi.en":["10.1134/S1995080222030027"],"dc.identifier.issn":["1995-0802"],"dc.identifier.uri":["http://hdl.handle.net/123456789/6570"],"dc.publisher":["MAIK NAUKA/INTERPERIODICA/SPRINGER233 SPRING ST, NEW YORK, NY 10013-1578"],"dc.publisher.en":["MAIK NAUKA/INTERPERIODICA/SPRINGER233 SPRING ST, NEW YORK, NY 10013-1578"],"dc.relation.ispartofseries":["LOBACHEVSKII JOURNAL OF MATHEMATICS;т. 42 № 15"],"dc.relation.ispartofseries.en":["LOBACHEVSKII JOURNAL OF MATHEMATICS;т. 42 № 15"],"subject":["dynamic system","Andronov-Hopf bifurcation","Lyapunov quantities","transcriticity","equilibrium point","stability","reaction-diffusion equation","cubic nonlinearity","Web of Science","Scopus"],"subject_keyword":["dynamic system","dynamic system","Andronov-Hopf bifurcation","Andronov-Hopf bifurcation","Lyapunov quantities","Lyapunov quantities","transcriticity","transcriticity","equilibrium point","equilibrium point","stability","stability","reaction-diffusion equation","reaction-diffusion equation","cubic nonlinearity","cubic nonlinearity","Web of Science","Web of Science","Scopus","Scopus"],"subject_ac":["dynamic system\n|||\ndynamic system","andronov-hopf bifurcation\n|||\nAndronov-Hopf bifurcation","lyapunov quantities\n|||\nLyapunov quantities","transcriticity\n|||\ntranscriticity","equilibrium point\n|||\nequilibrium point","stability\n|||\nstability","reaction-diffusion equation\n|||\nreaction-diffusion equation","cubic nonlinearity\n|||\ncubic nonlinearity","web of science\n|||\nWeb of Science","scopus\n|||\nScopus"],"subject_tax_0_filter":["dynamic system\n|||\ndynamic system","andronov-hopf bifurcation\n|||\nAndronov-Hopf bifurcation","lyapunov quantities\n|||\nLyapunov quantities","transcriticity\n|||\ntranscriticity","equilibrium point\n|||\nequilibrium point","stability\n|||\nstability","reaction-diffusion equation\n|||\nreaction-diffusion equation","cubic nonlinearity\n|||\ncubic nonlinearity","web of science\n|||\nWeb of Science","scopus\n|||\nScopus"],"subject_filter":["dynamic system\n|||\ndynamic system","andronov-hopf bifurcation\n|||\nAndronov-Hopf bifurcation","lyapunov quantities\n|||\nLyapunov quantities","transcriticity\n|||\ntranscriticity","equilibrium point\n|||\nequilibrium point","stability\n|||\nstability","reaction-diffusion equation\n|||\nreaction-diffusion equation","cubic nonlinearity\n|||\ncubic nonlinearity","web of science\n|||\nWeb of Science","scopus\n|||\nScopus"],"dc.subject_mlt":["dynamic system","Andronov-Hopf bifurcation","Lyapunov quantities","transcriticity","equilibrium point","stability","reaction-diffusion equation","cubic nonlinearity","Web of Science","Scopus"],"dc.subject":["dynamic system","Andronov-Hopf bifurcation","Lyapunov quantities","transcriticity","equilibrium point","stability","reaction-diffusion equation","cubic nonlinearity","Web of Science","Scopus"],"dc.subject.en":["dynamic system","Andronov-Hopf bifurcation","Lyapunov quantities","transcriticity","equilibrium point","stability","reaction-diffusion equation","cubic nonlinearity","Web of Science","Scopus"],"title":["Lyapunov Quantities for Andronov-Hopf Bifurcation Problem in Reaction-Diffusion Systems"],"title_keyword":["Lyapunov Quantities for Andronov-Hopf Bifurcation Problem in Reaction-Diffusion Systems"],"title_ac":["lyapunov quantities for andronov-hopf bifurcation problem in reaction-diffusion systems\n|||\nLyapunov Quantities for Andronov-Hopf Bifurcation Problem in Reaction-Diffusion Systems"],"dc.title_sort":"Lyapunov Quantities for Andronov-Hopf Bifurcation Problem in Reaction-Diffusion Systems","dc.title_hl":["Lyapunov Quantities for Andronov-Hopf Bifurcation Problem in Reaction-Diffusion Systems"],"dc.title_mlt":["Lyapunov Quantities for Andronov-Hopf Bifurcation Problem in Reaction-Diffusion Systems"],"dc.title":["Lyapunov Quantities for Andronov-Hopf Bifurcation Problem in Reaction-Diffusion Systems"],"dc.title_stored":["Lyapunov Quantities for Andronov-Hopf Bifurcation Problem in Reaction-Diffusion Systems\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen"],"dc.title.en":["Lyapunov Quantities for Andronov-Hopf Bifurcation Problem in Reaction-Diffusion Systems"],"dc.title.alternative":["Lyapunov Quantities for Andronov-Hopf Bifurcation Problem in Reaction-Diffusion Systems"],"dc.title.alternative.en":["Lyapunov Quantities for Andronov-Hopf Bifurcation Problem in Reaction-Diffusion Systems"],"dc.type":["Article"],"dc.type.en":["Article"],"publication_grp":["123456789/6570"],"bi_2_dis_filter":["abushahmina, gr\n|||\nAbushahmina, GR","gusarova, ni\n|||\nGusarova, NI","yumagulov, mg\n|||\nYumagulov, MG"],"bi_2_dis_partial":["Yumagulov, MG","Gusarova, NI","Abushahmina, GR"],"bi_2_dis_value_filter":["Yumagulov, MG","Gusarova, NI","Abushahmina, GR"],"bi_4_dis_filter":["stability\n|||\nstability","dynamic system\n|||\ndynamic system","reaction-diffusion equation\n|||\nreaction-diffusion equation","andronov-hopf bifurcation\n|||\nAndronov-Hopf bifurcation","cubic nonlinearity\n|||\ncubic nonlinearity","equilibrium point\n|||\nequilibrium point","scopus\n|||\nScopus","transcriticity\n|||\ntranscriticity","lyapunov quantities\n|||\nLyapunov quantities","web of science\n|||\nWeb of Science"],"bi_4_dis_partial":["reaction-diffusion equation","cubic nonlinearity","Web of Science","equilibrium point","Scopus","Lyapunov quantities","dynamic system","Andronov-Hopf bifurcation","transcriticity","stability"],"bi_4_dis_value_filter":["reaction-diffusion equation","cubic nonlinearity","Web of Science","equilibrium point","Scopus","Lyapunov quantities","dynamic system","Andronov-Hopf bifurcation","transcriticity","stability"],"bi_sort_1_sort":"lyapunov quantities for andronov-hopf bifurcation problem in reaction-diffusion systems","bi_sort_2_sort":"2021","bi_sort_3_sort":"2022-04-15T09:38:34Z","read":["g0"],"_version_":1730169768091058176},{"SolrIndexer.lastIndexed":"2022-09-30T05:18:29.588Z","search.uniqueid":"2-6051","search.resourcetype":2,"search.resourceid":6051,"handle":"123456789/6956","location":["m229","l684"],"location.comm":["229"],"location.coll":["684"],"withdrawn":"false","discoverable":"true","dc.abstract":["Цель исследования – анализ данных об атипичных формах нейрофиброматоза 1-го типа и генофенотипических корреляциях при этом заболевании. Материал и методы. Поиск соответствующих\nисточников проводился в системах Scopus, Web of Science, PubMed с включением публикаций с мая\n1993 г. по октябрь 2021 г. Из 318 найденных исследований 59 были использованы для написания\nсистематического обзора. Результаты. Найдены работы с описанием атипичных форм нейрофиброматоза 1-го типа со стертым течением без проявления опухолевого синдрома, которые обусловлены\nспецифическими мутациями в гене NF1 (вызывающими замены аминокислот в нейрофибромине:\np.Arg1038, p.Met1149, p.Arg1809, или делецию аминокислот: p.Met990del, p.Met992del). Для больных с\nмикроделециями всего гена NF1 и прилегающих областей характерны более тяжелые проявления нейрофиброматоза 1-го типа (чаще проявляются лицевой дизморфизм, скелетные и сердечно-сосудистые\nаномалии, трудности в обучении и симптоматические спинальные нейрофибромы). С ранней манифестацией опухолей ассоциированы мутации сайтов сплайсинга и протяженные делеции гена NF1, с\nглиомами зрительных нервов – мутации на 5’-конце гена, вызывающие укорочение белкового продукта,\nсо структурным поражением головного мозга – мутация c.3721C>T (p.R1241*), с эндокринными расстройствами – мутация c.6855C>A (p.Y2285*). Описана клиническая картина нейрофиброматоза 1-го\nтипа, схожая с липоматозом и синдромом Джаффе–Кампаначчи, не связанная с конкретным типом\nмутации. Заключение. Несмотря на выраженную клиническую вариабельность нейрофиброматоза\n1-го типа даже у членов одной семьи, в ряде работ описаны гено-фенотипические корреляции. Так как\nбелок нейрофибромин имеет сложную структуру с несколькими функциональными доменами, предполагается роль генов-модификаторов и эпигенетических факторов в патогенезе нейрофиброматоза 1-го\nтипа. Показано, что на выраженность опухолевого синдрома влияют особенности метилирования гена\nNF1 и прилегающих областей, а сам ген взаимосвязан с определенными микроРНК. Поэтому перспективным способом лечения нейрофиброматоза 1-го типа может стать таргетная терапия, нацеленная\nна специфические некодирующие РНК для восстановления нормальной экспрессии гена NF1."],"dc.abstract.ru_RU":["Цель исследования – анализ данных об атипичных формах нейрофиброматоза 1-го типа и генофенотипических корреляциях при этом заболевании. Материал и методы. Поиск соответствующих\nисточников проводился в системах Scopus, Web of Science, PubMed с включением публикаций с мая\n1993 г. по октябрь 2021 г. Из 318 найденных исследований 59 были использованы для написания\nсистематического обзора. Результаты. Найдены работы с описанием атипичных форм нейрофиброматоза 1-го типа со стертым течением без проявления опухолевого синдрома, которые обусловлены\nспецифическими мутациями в гене NF1 (вызывающими замены аминокислот в нейрофибромине:\np.Arg1038, p.Met1149, p.Arg1809, или делецию аминокислот: p.Met990del, p.Met992del). Для больных с\nмикроделециями всего гена NF1 и прилегающих областей характерны более тяжелые проявления нейрофиброматоза 1-го типа (чаще проявляются лицевой дизморфизм, скелетные и сердечно-сосудистые\nаномалии, трудности в обучении и симптоматические спинальные нейрофибромы). С ранней манифестацией опухолей ассоциированы мутации сайтов сплайсинга и протяженные делеции гена NF1, с\nглиомами зрительных нервов – мутации на 5’-конце гена, вызывающие укорочение белкового продукта,\nсо структурным поражением головного мозга – мутация c.3721C>T (p.R1241*), с эндокринными расстройствами – мутация c.6855C>A (p.Y2285*). Описана клиническая картина нейрофиброматоза 1-го\nтипа, схожая с липоматозом и синдромом Джаффе–Кампаначчи, не связанная с конкретным типом\nмутации. Заключение. Несмотря на выраженную клиническую вариабельность нейрофиброматоза\n1-го типа даже у членов одной семьи, в ряде работ описаны гено-фенотипические корреляции. Так как\nбелок нейрофибромин имеет сложную структуру с несколькими функциональными доменами, предполагается роль генов-модификаторов и эпигенетических факторов в патогенезе нейрофиброматоза 1-го\nтипа. Показано, что на выраженность опухолевого синдрома влияют особенности метилирования гена\nNF1 и прилегающих областей, а сам ген взаимосвязан с определенными микроРНК. Поэтому перспективным способом лечения нейрофиброматоза 1-го типа может стать таргетная терапия, нацеленная\nна специфические некодирующие РНК для восстановления нормальной экспрессии гена NF1."],"author":["Мустафин, Р.Н.","Mustafin, R.N."],"author_keyword":["Мустафин, Р.Н.","Mustafin, R.N."],"author_ac":["мустафин, р.н.\n|||\nМустафин, Р.Н.","mustafin, r.n.\n|||\nMustafin, R.N."],"author_filter":["мустафин, р.н.\n|||\nМустафин, Р.Н.","mustafin, r.n.\n|||\nMustafin, R.N."],"dc.contributor.author_hl":["Мустафин, Р.Н.","Mustafin, R.N."],"dc.contributor.author_mlt":["Мустафин, Р.Н.","Mustafin, R.N."],"dc.contributor.author":["Мустафин, Р.Н.","Mustafin, R.N."],"dc.contributor.author_stored":["Мустафин, Р.Н.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nru_RU","Mustafin, R.N.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen"],"dc.contributor.author.ru_RU":["Мустафин, Р.Н."],"dc.contributor.author.en":["Mustafin, R.N."],"dc.date.accessioned_dt":"2022-09-30T05:15:17Z","dc.date.accessioned":["2022-09-30T05:15:17Z"],"dc.date.available":["2022-09-30T05:15:17Z"],"dateIssued":["2022-01-01"],"dateIssued_keyword":["2022-01-01","2022"],"dateIssued_ac":["2022-01-01\n|||\n2022-01-01","2022"],"dateIssued.year":[2022],"dateIssued.year_sort":"2022","dc.date.issued_dt":"2022-01-01T00:00:00Z","dc.date.issued":["2022-01-01"],"dc.date.issued_stored":["2022-01-01\n|||\nnull\n|||\nnull\n|||\nnull\n|||\n"],"dc.description.abstract_hl":["Purpose of the study: Analysis of available data on geno-phenotypic correlations and atypical forms of neurofibromatosis type 1. Material and Methods. We searched for relevant sources in the Scopus, Web of Science, PubMed systems, including publications from May 1993 to October 2021. Of the 318 studies we identified, 59 were used to write a systematic review. Results. We found studies describing atypical forms of neurofibromatosis type 1 with an erased course without manifestation of a tumor syndrome, which are caused by specific mutations in the NF1 gene (causing substitutions of amino acids in neurofibromin: p.Arg1038, p.Met1149, p.Arg1809, or deletion of amino acids: p.Met990del, p.Met992del). NF1 patients with microdeletions are characterized by more severe disease symptoms (more often facial dysmorphism, skeletal and cardiovascular abnormalities, learning difficulties, and symptomatic spinal neurofibromas). Mutations of splicing sites and extended deletions of the NF1 gene are associated with early manifestation of tumors, mutations at the 5’-end of the gene, causing a shortening of the protein product, are associated with optic nerve gliomas. The mutation c.3721C>T (p.R1241*) correlated with structural brain damage, and c.6855C>A (p.Y2285*) with endocrine disorders. The manifestations of NF1, similar to lipomatosis and Jaffe–Campanacci syndrome, not associated with a specific type of mutation are described. Conclusion. In spite of pronounced clinical variability of the disease, even among members of the same family, several studies have described genotype-phenotype correlations. Therefore, the role of modifier genes and epigenetic factors in the pathogenesis of NF1 is assumed, since the neurofibromin protein has a complex structure with several functional domains. It has been shown that the severity of the tumor syndrome is influenced by the methylation characteristics of NF1 gene and adjacent areas. In addition, NF1 gene is associated with a variety of microRNAs. Therefore, targeted therapy aimed at specific non-coding RNAs to restore normal expression of NF1 gene can become a promising treatment for NF1. © 2022, Tomsk National Research Medical Center of the Russian Academy of Sciences. All rights reserved."],"dc.description.abstract":["Purpose of the study: Analysis of available data on geno-phenotypic correlations and atypical forms of neurofibromatosis type 1. Material and Methods. We searched for relevant sources in the Scopus, Web of Science, PubMed systems, including publications from May 1993 to October 2021. Of the 318 studies we identified, 59 were used to write a systematic review. Results. We found studies describing atypical forms of neurofibromatosis type 1 with an erased course without manifestation of a tumor syndrome, which are caused by specific mutations in the NF1 gene (causing substitutions of amino acids in neurofibromin: p.Arg1038, p.Met1149, p.Arg1809, or deletion of amino acids: p.Met990del, p.Met992del). NF1 patients with microdeletions are characterized by more severe disease symptoms (more often facial dysmorphism, skeletal and cardiovascular abnormalities, learning difficulties, and symptomatic spinal neurofibromas). Mutations of splicing sites and extended deletions of the NF1 gene are associated with early manifestation of tumors, mutations at the 5’-end of the gene, causing a shortening of the protein product, are associated with optic nerve gliomas. The mutation c.3721C>T (p.R1241*) correlated with structural brain damage, and c.6855C>A (p.Y2285*) with endocrine disorders. The manifestations of NF1, similar to lipomatosis and Jaffe–Campanacci syndrome, not associated with a specific type of mutation are described. Conclusion. In spite of pronounced clinical variability of the disease, even among members of the same family, several studies have described genotype-phenotype correlations. Therefore, the role of modifier genes and epigenetic factors in the pathogenesis of NF1 is assumed, since the neurofibromin protein has a complex structure with several functional domains. It has been shown that the severity of the tumor syndrome is influenced by the methylation characteristics of NF1 gene and adjacent areas. In addition, NF1 gene is associated with a variety of microRNAs. Therefore, targeted therapy aimed at specific non-coding RNAs to restore normal expression of NF1 gene can become a promising treatment for NF1. © 2022, Tomsk National Research Medical Center of the Russian Academy of Sciences. All rights reserved."],"dc.description.abstract.en":["Purpose of the study: Analysis of available data on geno-phenotypic correlations and atypical forms of neurofibromatosis type 1. Material and Methods. We searched for relevant sources in the Scopus, Web of Science, PubMed systems, including publications from May 1993 to October 2021. Of the 318 studies we identified, 59 were used to write a systematic review. Results. We found studies describing atypical forms of neurofibromatosis type 1 with an erased course without manifestation of a tumor syndrome, which are caused by specific mutations in the NF1 gene (causing substitutions of amino acids in neurofibromin: p.Arg1038, p.Met1149, p.Arg1809, or deletion of amino acids: p.Met990del, p.Met992del). NF1 patients with microdeletions are characterized by more severe disease symptoms (more often facial dysmorphism, skeletal and cardiovascular abnormalities, learning difficulties, and symptomatic spinal neurofibromas). Mutations of splicing sites and extended deletions of the NF1 gene are associated with early manifestation of tumors, mutations at the 5’-end of the gene, causing a shortening of the protein product, are associated with optic nerve gliomas. The mutation c.3721C>T (p.R1241*) correlated with structural brain damage, and c.6855C>A (p.Y2285*) with endocrine disorders. The manifestations of NF1, similar to lipomatosis and Jaffe–Campanacci syndrome, not associated with a specific type of mutation are described. Conclusion. In spite of pronounced clinical variability of the disease, even among members of the same family, several studies have described genotype-phenotype correlations. Therefore, the role of modifier genes and epigenetic factors in the pathogenesis of NF1 is assumed, since the neurofibromin protein has a complex structure with several functional domains. It has been shown that the severity of the tumor syndrome is influenced by the methylation characteristics of NF1 gene and adjacent areas. In addition, NF1 gene is associated with a variety of microRNAs. Therefore, targeted therapy aimed at specific non-coding RNAs to restore normal expression of NF1 gene can become a promising treatment for NF1. © 2022, Tomsk National Research Medical Center of the Russian Academy of Sciences. All rights reserved."],"dc.doi":["10.21294/1814-4861-2022-21-4-98-109"],"dc.identifier.issn":["1814-4861"],"dc.identifier.uri":["http://hdl.handle.net/123456789/6956"],"dc.publisher":["Tomsk National Research Medical Center of the Russian Academy of Sciences"],"dc.publisher.en":["Tomsk National Research Medical Center of the Russian Academy of Sciences"],"dc.relation.ispartofseries":["Siberian Journal of Oncology;т. 21 № 4"],"dc.relation.ispartofseries.en":["Siberian Journal of Oncology;т. 21 № 4"],"subject":["atypical manifestations","epigenetic factors","lipomatosis","malignant tumors","microRNA","modifier genes","neurofibromatosis type 1","NF1 gene","Scopus","атипичные проявления","ген NF1","гены-модификаторы","злокачественные опухоли","липоматоз","микроРНК","нейрофиброматоз 1-го типа","эпигенетические факторы"],"subject_keyword":["atypical manifestations","atypical manifestations","epigenetic factors","epigenetic factors","lipomatosis","lipomatosis","malignant tumors","malignant tumors","microRNA","microRNA","modifier genes","modifier genes","neurofibromatosis type 1","neurofibromatosis type 1","NF1 gene","NF1 gene","Scopus","Scopus","атипичные проявления","атипичные проявления","ген NF1","ген NF1","гены-модификаторы","гены-модификаторы","злокачественные опухоли","злокачественные опухоли","липоматоз","липоматоз","микроРНК","микроРНК","нейрофиброматоз 1-го типа","нейрофиброматоз 1-го типа","эпигенетические факторы","эпигенетические факторы"],"subject_ac":["atypical manifestations\n|||\natypical manifestations","epigenetic factors\n|||\nepigenetic factors","lipomatosis\n|||\nlipomatosis","malignant tumors\n|||\nmalignant tumors","microrna\n|||\nmicroRNA","modifier genes\n|||\nmodifier genes","neurofibromatosis type 1\n|||\nneurofibromatosis type 1","nf1 gene\n|||\nNF1 gene","scopus\n|||\nScopus","атипичные проявления\n|||\nатипичные проявления","ген nf1\n|||\nген NF1","гены-модификаторы\n|||\nгены-модификаторы","злокачественные опухоли\n|||\nзлокачественные опухоли","липоматоз\n|||\nлипоматоз","микрорнк\n|||\nмикроРНК","нейрофиброматоз 1-го типа\n|||\nнейрофиброматоз 1-го типа","эпигенетические факторы\n|||\nэпигенетические факторы"],"subject_tax_0_filter":["atypical manifestations\n|||\natypical manifestations","epigenetic factors\n|||\nepigenetic factors","lipomatosis\n|||\nlipomatosis","malignant tumors\n|||\nmalignant tumors","microrna\n|||\nmicroRNA","modifier genes\n|||\nmodifier genes","neurofibromatosis type 1\n|||\nneurofibromatosis type 1","nf1 gene\n|||\nNF1 gene","scopus\n|||\nScopus","атипичные проявления\n|||\nатипичные проявления","ген nf1\n|||\nген NF1","гены-модификаторы\n|||\nгены-модификаторы","злокачественные опухоли\n|||\nзлокачественные опухоли","липоматоз\n|||\nлипоматоз","микрорнк\n|||\nмикроРНК","нейрофиброматоз 1-го типа\n|||\nнейрофиброматоз 1-го типа","эпигенетические факторы\n|||\nэпигенетические факторы"],"subject_filter":["atypical manifestations\n|||\natypical manifestations","epigenetic factors\n|||\nepigenetic factors","lipomatosis\n|||\nlipomatosis","malignant tumors\n|||\nmalignant tumors","microrna\n|||\nmicroRNA","modifier genes\n|||\nmodifier genes","neurofibromatosis type 1\n|||\nneurofibromatosis type 1","nf1 gene\n|||\nNF1 gene","scopus\n|||\nScopus","атипичные проявления\n|||\nатипичные проявления","ген nf1\n|||\nген NF1","гены-модификаторы\n|||\nгены-модификаторы","злокачественные опухоли\n|||\nзлокачественные опухоли","липоматоз\n|||\nлипоматоз","микрорнк\n|||\nмикроРНК","нейрофиброматоз 1-го типа\n|||\nнейрофиброматоз 1-го типа","эпигенетические факторы\n|||\nэпигенетические факторы"],"dc.subject_mlt":["atypical manifestations","epigenetic factors","lipomatosis","malignant tumors","microRNA","modifier genes","neurofibromatosis type 1","NF1 gene","Scopus","атипичные проявления","ген NF1","гены-модификаторы","злокачественные опухоли","липоматоз","микроРНК","нейрофиброматоз 1-го типа","эпигенетические факторы"],"dc.subject":["atypical manifestations","epigenetic factors","lipomatosis","malignant tumors","microRNA","modifier genes","neurofibromatosis type 1","NF1 gene","Scopus","атипичные проявления","ген NF1","гены-модификаторы","злокачественные опухоли","липоматоз","микроРНК","нейрофиброматоз 1-го типа","эпигенетические факторы"],"dc.subject.en":["atypical manifestations","epigenetic factors","lipomatosis","malignant tumors","microRNA","modifier genes","neurofibromatosis type 1","NF1 gene","Scopus"],"dc.subject.ru_RU":["атипичные проявления","ген NF1","гены-модификаторы","злокачественные опухоли","липоматоз","микроРНК","нейрофиброматоз 1-го типа","эпигенетические факторы"],"title":["ATYPICAL CLINICAL MANIFESTATIONS AND GENOTYPE-PHENOTYPE CORRELATIONS OF NEUROFIBROMATOSIS TYPE 1"],"title_keyword":["ATYPICAL CLINICAL MANIFESTATIONS AND GENOTYPE-PHENOTYPE CORRELATIONS OF NEUROFIBROMATOSIS TYPE 1"],"title_ac":["atypical clinical manifestations and genotype-phenotype correlations of neurofibromatosis type 1\n|||\nATYPICAL CLINICAL MANIFESTATIONS AND GENOTYPE-PHENOTYPE CORRELATIONS OF NEUROFIBROMATOSIS TYPE 1"],"dc.title_sort":"ATYPICAL CLINICAL MANIFESTATIONS AND GENOTYPE-PHENOTYPE CORRELATIONS OF NEUROFIBROMATOSIS TYPE 1","dc.title_hl":["ATYPICAL CLINICAL MANIFESTATIONS AND GENOTYPE-PHENOTYPE CORRELATIONS OF NEUROFIBROMATOSIS TYPE 1"],"dc.title_mlt":["ATYPICAL CLINICAL MANIFESTATIONS AND GENOTYPE-PHENOTYPE CORRELATIONS OF NEUROFIBROMATOSIS TYPE 1"],"dc.title":["ATYPICAL CLINICAL MANIFESTATIONS AND GENOTYPE-PHENOTYPE CORRELATIONS OF NEUROFIBROMATOSIS TYPE 1"],"dc.title_stored":["ATYPICAL CLINICAL MANIFESTATIONS AND GENOTYPE-PHENOTYPE CORRELATIONS OF NEUROFIBROMATOSIS TYPE 1\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen"],"dc.title.en":["ATYPICAL CLINICAL MANIFESTATIONS AND GENOTYPE-PHENOTYPE CORRELATIONS OF NEUROFIBROMATOSIS TYPE 1"],"dc.title.alternative":["АТИПИЧНЫЕ ФОРМЫ И ГЕНО-ФЕНОТИПИЧЕСКИЕ КОРРЕЛЯЦИИ НЕЙРОФИБРОМАТОЗА 1-ГО ТИПА"],"dc.title.alternative.ru_RU":["АТИПИЧНЫЕ ФОРМЫ И ГЕНО-ФЕНОТИПИЧЕСКИЕ КОРРЕЛЯЦИИ НЕЙРОФИБРОМАТОЗА 1-ГО ТИПА"],"dc.type":["Article"],"dc.type.ru_RU":["Article"],"publication_grp":["123456789/6956"],"bi_2_dis_filter":["mustafin, r.n.\n|||\nMustafin, R.N.","мустафин, р.н.\n|||\nМустафин, Р.Н."],"bi_2_dis_partial":["Mustafin, R.N.","Мустафин, Р.Н."],"bi_2_dis_value_filter":["Mustafin, R.N.","Мустафин, Р.Н."],"bi_4_dis_filter":["atypical manifestations\n|||\natypical manifestations","гены-модификаторы\n|||\nгены-модификаторы","microrna\n|||\nmicroRNA","scopus\n|||\nScopus","атипичные проявления\n|||\nатипичные проявления","malignant tumors\n|||\nmalignant tumors","ген nf1\n|||\nген NF1","nf1 gene\n|||\nNF1 gene","lipomatosis\n|||\nlipomatosis","эпигенетические факторы\n|||\nэпигенетические факторы","липоматоз\n|||\nлипоматоз","modifier genes\n|||\nmodifier genes","злокачественные опухоли\n|||\nзлокачественные опухоли","микрорнк\n|||\nмикроРНК","neurofibromatosis type 1\n|||\nneurofibromatosis type 1","epigenetic factors\n|||\nepigenetic factors","нейрофиброматоз 1-го типа\n|||\nнейрофиброматоз 1-го типа"],"bi_4_dis_partial":["микроРНК","lipomatosis","Scopus","злокачественные опухоли","modifier genes","эпигенетические факторы","ген NF1","atypical manifestations","липоматоз","malignant tumors","neurofibromatosis type 1","epigenetic factors","microRNA","атипичные проявления","NF1 gene","нейрофиброматоз 1-го типа","гены-модификаторы"],"bi_4_dis_value_filter":["микроРНК","lipomatosis","Scopus","злокачественные опухоли","modifier genes","эпигенетические факторы","ген NF1","atypical manifestations","липоматоз","malignant tumors","neurofibromatosis type 1","epigenetic factors","microRNA","атипичные проявления","NF1 gene","нейрофиброматоз 1-го типа","гены-модификаторы"],"bi_sort_1_sort":"atypical clinical manifestations and genotype-phenotype correlations of neurofibromatosis type 1","bi_sort_2_sort":"2022","bi_sort_3_sort":"2022-09-30T05:15:17Z","read":["g0"],"_version_":1745370595561832448},{"SolrIndexer.lastIndexed":"2025-02-14T06:01:43.856Z","search.uniqueid":"2-7779","search.resourcetype":2,"search.resourceid":7779,"handle":"123456789/8666","location":["m229","l684"],"location.comm":["229"],"location.coll":["684"],"withdrawn":"false","discoverable":"true","author":["Kudreyko, Aleksey","Chigrinov, Vladimir","Perestoronina, Arina"],"author_keyword":["Kudreyko, Aleksey","Chigrinov, Vladimir","Perestoronina, Arina"],"author_ac":["kudreyko, aleksey\n|||\nKudreyko, Aleksey","chigrinov, vladimir\n|||\nChigrinov, Vladimir","perestoronina, arina\n|||\nPerestoronina, Arina"],"author_filter":["kudreyko, aleksey\n|||\nKudreyko, Aleksey","chigrinov, vladimir\n|||\nChigrinov, Vladimir","perestoronina, arina\n|||\nPerestoronina, Arina"],"dc.contributor.author_hl":["Kudreyko, Aleksey","Chigrinov, Vladimir","Perestoronina, Arina"],"dc.contributor.author_mlt":["Kudreyko, Aleksey","Chigrinov, Vladimir","Perestoronina, Arina"],"dc.contributor.author":["Kudreyko, Aleksey","Chigrinov, Vladimir","Perestoronina, Arina"],"dc.contributor.author_stored":["Kudreyko, Aleksey\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Chigrinov, Vladimir\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Perestoronina, Arina\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen"],"dc.contributor.author.en":["Kudreyko, Aleksey","Chigrinov, Vladimir","Perestoronina, Arina"],"dc.date.accessioned_dt":"2025-02-14T05:59:24Z","dc.date.accessioned":["2025-02-14T05:59:24Z"],"dc.date.available":["2025-02-14T05:59:24Z"],"dateIssued":["2025-01-01"],"dateIssued_keyword":["2025-01-01","2025"],"dateIssued_ac":["2025-01-01\n|||\n2025-01-01","2025"],"dateIssued.year":[2025],"dateIssued.year_sort":"2025","dc.date.issued_dt":"2025-01-01T00:00:00Z","dc.date.issued":["2025-01-01"],"dc.date.issued_stored":["2025-01-01\n|||\nnull\n|||\nnull\n|||\nnull\n|||\n"],"dc.description.abstract_hl":["Properties of surface anchoring depend on the absorbed exposure energy and various potential interactions associated with liquid crystal and azo dye layers. In this study, we investigate a model of dispersion, steric and photoinduced interactions with the goal of providing a qualitative and quantitative description of orientationally ordered hard uniaxial liquid crystals and azo dye molecules. By using the Onsager theory, we estimated the effect of excluded volume. Typical repulsive potentials between liquid crystal and azo dye molecules are displayed graphically. The presence of statistical dispersion in molecular alignment of liquid crystals leads to potential wells in dipole–dipole interactions. Our mean field theory investigation of dipole–dipole interactions shows that the anchoring free energy is governed by the net interaction energy associated with the averaged dipole moments of liquid crystal and azo dye molecules, photoaligned surface dipole moments, and local charge densities. We also use the Fokker–Planck equation to show that rotational diffusion is described by the effective mean field potential, which includes photoinduced and van der Waals interactions. Our findings underscore the potential of mean field theory for intermolecular couplings in photoaligned surfaces, opening up new pathways of molecular design for a broad range of parameters. © 2024 by the authors."],"dc.description.abstract":["Properties of surface anchoring depend on the absorbed exposure energy and various potential interactions associated with liquid crystal and azo dye layers. In this study, we investigate a model of dispersion, steric and photoinduced interactions with the goal of providing a qualitative and quantitative description of orientationally ordered hard uniaxial liquid crystals and azo dye molecules. By using the Onsager theory, we estimated the effect of excluded volume. Typical repulsive potentials between liquid crystal and azo dye molecules are displayed graphically. The presence of statistical dispersion in molecular alignment of liquid crystals leads to potential wells in dipole–dipole interactions. Our mean field theory investigation of dipole–dipole interactions shows that the anchoring free energy is governed by the net interaction energy associated with the averaged dipole moments of liquid crystal and azo dye molecules, photoaligned surface dipole moments, and local charge densities. We also use the Fokker–Planck equation to show that rotational diffusion is described by the effective mean field potential, which includes photoinduced and van der Waals interactions. Our findings underscore the potential of mean field theory for intermolecular couplings in photoaligned surfaces, opening up new pathways of molecular design for a broad range of parameters. © 2024 by the authors."],"dc.description.abstract.en":["Properties of surface anchoring depend on the absorbed exposure energy and various potential interactions associated with liquid crystal and azo dye layers. In this study, we investigate a model of dispersion, steric and photoinduced interactions with the goal of providing a qualitative and quantitative description of orientationally ordered hard uniaxial liquid crystals and azo dye molecules. By using the Onsager theory, we estimated the effect of excluded volume. Typical repulsive potentials between liquid crystal and azo dye molecules are displayed graphically. The presence of statistical dispersion in molecular alignment of liquid crystals leads to potential wells in dipole–dipole interactions. Our mean field theory investigation of dipole–dipole interactions shows that the anchoring free energy is governed by the net interaction energy associated with the averaged dipole moments of liquid crystal and azo dye molecules, photoaligned surface dipole moments, and local charge densities. We also use the Fokker–Planck equation to show that rotational diffusion is described by the effective mean field potential, which includes photoinduced and van der Waals interactions. Our findings underscore the potential of mean field theory for intermolecular couplings in photoaligned surfaces, opening up new pathways of molecular design for a broad range of parameters. © 2024 by the authors."],"dc.doi":["10.3390/cryst15010022"],"dc.doi.en":["10.3390/cryst15010022"],"dc.identifier.issn":["2073-4352"],"dc.identifier.uri":["http://hdl.handle.net/123456789/8666"],"dc.identifier.uri.en":["http://hdl.handle.net/123456789/8666"],"dc.language.iso":["en"],"dc.language.iso.en":["en"],"dc.publisher":["Multidisciplinary Digital Publishing Institute (MDPI)"],"dc.publisher.en":["Multidisciplinary Digital Publishing Institute (MDPI)"],"dc.relation.ispartofseries":["Crystals;т. 15 № 1"],"dc.relation.ispartofseries.en":["Crystals;т. 15 № 1"],"subject":["dipole–dipole interactions","mean field theory","Onsager theory","photoalignment","rotational diffusion","steric interactions","Scopus"],"subject_keyword":["dipole–dipole interactions","dipole–dipole interactions","mean field theory","mean field theory","Onsager theory","Onsager theory","photoalignment","photoalignment","rotational diffusion","rotational diffusion","steric interactions","steric interactions","Scopus","Scopus"],"subject_ac":["dipole–dipole interactions\n|||\ndipole–dipole interactions","mean field theory\n|||\nmean field theory","onsager theory\n|||\nOnsager theory","photoalignment\n|||\nphotoalignment","rotational diffusion\n|||\nrotational diffusion","steric interactions\n|||\nsteric interactions","scopus\n|||\nScopus"],"subject_tax_0_filter":["dipole–dipole interactions\n|||\ndipole–dipole interactions","mean field theory\n|||\nmean field theory","onsager theory\n|||\nOnsager theory","photoalignment\n|||\nphotoalignment","rotational diffusion\n|||\nrotational diffusion","steric interactions\n|||\nsteric interactions","scopus\n|||\nScopus"],"subject_filter":["dipole–dipole interactions\n|||\ndipole–dipole interactions","mean field theory\n|||\nmean field theory","onsager theory\n|||\nOnsager theory","photoalignment\n|||\nphotoalignment","rotational diffusion\n|||\nrotational diffusion","steric interactions\n|||\nsteric interactions","scopus\n|||\nScopus"],"dc.subject_mlt":["dipole–dipole interactions","mean field theory","Onsager theory","photoalignment","rotational diffusion","steric interactions","Scopus"],"dc.subject":["dipole–dipole interactions","mean field theory","Onsager theory","photoalignment","rotational diffusion","steric interactions","Scopus"],"dc.subject.en":["dipole–dipole interactions","mean field theory","Onsager theory","photoalignment","rotational diffusion","steric interactions","Scopus"],"title":["Photoinduced Interactions in Thin Films of Azo Dyes and Planar-Aligned Nematic Liquid Crystal"],"title_keyword":["Photoinduced Interactions in Thin Films of Azo Dyes and Planar-Aligned Nematic Liquid Crystal"],"title_ac":["photoinduced interactions in thin films of azo dyes and planar-aligned nematic liquid crystal\n|||\nPhotoinduced Interactions in Thin Films of Azo Dyes and Planar-Aligned Nematic Liquid Crystal"],"dc.title_sort":"Photoinduced Interactions in Thin Films of Azo Dyes and Planar-Aligned Nematic Liquid Crystal","dc.title_hl":["Photoinduced Interactions in Thin Films of Azo Dyes and Planar-Aligned Nematic Liquid Crystal"],"dc.title_mlt":["Photoinduced Interactions in Thin Films of Azo Dyes and Planar-Aligned Nematic Liquid Crystal"],"dc.title":["Photoinduced Interactions in Thin Films of Azo Dyes and Planar-Aligned Nematic Liquid Crystal"],"dc.title_stored":["Photoinduced Interactions in Thin Films of Azo Dyes and Planar-Aligned Nematic Liquid Crystal\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen"],"dc.title.en":["Photoinduced Interactions in Thin Films of Azo Dyes and Planar-Aligned Nematic Liquid Crystal"],"dc.title.alternative":["Photoinduced Interactions in Thin Films of Azo Dyes and Planar-Aligned Nematic Liquid Crystal"],"dc.title.alternative.en":["Photoinduced Interactions in Thin Films of Azo Dyes and Planar-Aligned Nematic Liquid Crystal"],"dc.type":["Article"],"dc.type.en":["Article"],"publication_grp":["123456789/8666"],"bi_2_dis_filter":["chigrinov, vladimir\n|||\nChigrinov, Vladimir","kudreyko, aleksey\n|||\nKudreyko, Aleksey","perestoronina, arina\n|||\nPerestoronina, Arina"],"bi_2_dis_partial":["Kudreyko, Aleksey","Chigrinov, Vladimir","Perestoronina, Arina"],"bi_2_dis_value_filter":["Kudreyko, Aleksey","Chigrinov, Vladimir","Perestoronina, Arina"],"bi_4_dis_filter":["dipole–dipole interactions\n|||\ndipole–dipole interactions","rotational diffusion\n|||\nrotational diffusion","onsager theory\n|||\nOnsager theory","steric interactions\n|||\nsteric interactions","scopus\n|||\nScopus","mean field theory\n|||\nmean field theory","photoalignment\n|||\nphotoalignment"],"bi_4_dis_partial":["mean field theory","photoalignment","dipole–dipole interactions","Onsager theory","rotational diffusion","Scopus","steric interactions"],"bi_4_dis_value_filter":["mean field theory","photoalignment","dipole–dipole interactions","Onsager theory","rotational diffusion","Scopus","steric interactions"],"bi_sort_1_sort":"photoinduced interactions in thin films of azo dyes and planar-aligned nematic liquid crystal","bi_sort_2_sort":"2025","bi_sort_3_sort":"2025-02-14T05:59:24Z","read":["g0"],"_version_":1824011482680000512},{"SolrIndexer.lastIndexed":"2022-11-18T07:19:14.052Z","search.uniqueid":"2-6046","search.resourcetype":2,"search.resourceid":6046,"handle":"123456789/6951","location":["m229","l684"],"location.comm":["229"],"location.coll":["684"],"withdrawn":"false","discoverable":"true","author":["Kuterbekov, K.A.","Balapanov, M. Kh.","Kubenova, M.M.","Ishembetov, R. Kh.","Zeleev, M. Kh.","Yakshibaev, R.A.","Kabyshev, A.M.","Alina, R.A.","Bekmyrza, K. Zh.","Baikhozhaeva, B.U.","Abseitov, E.T.","Abseitov, E.T."],"author_keyword":["Kuterbekov, K.A.","Balapanov, M. Kh.","Kubenova, M.M.","Ishembetov, R. Kh.","Zeleev, M. Kh.","Yakshibaev, R.A.","Kabyshev, A.M.","Alina, R.A.","Bekmyrza, K. Zh.","Baikhozhaeva, B.U.","Abseitov, E.T.","Abseitov, E.T."],"author_ac":["kuterbekov, k.a.\n|||\nKuterbekov, K.A.","balapanov, m. kh.\n|||\nBalapanov, M. Kh.","kubenova, m.m.\n|||\nKubenova, M.M.","ishembetov, r. kh.\n|||\nIshembetov, R. Kh.","zeleev, m. kh.\n|||\nZeleev, M. Kh.","yakshibaev, r.a.\n|||\nYakshibaev, R.A.","kabyshev, a.m.\n|||\nKabyshev, A.M.","alina, r.a.\n|||\nAlina, R.A.","bekmyrza, k. zh.\n|||\nBekmyrza, K. Zh.","baikhozhaeva, b.u.\n|||\nBaikhozhaeva, B.U.","abseitov, e.t.\n|||\nAbseitov, E.T.","abseitov, e.t.\n|||\nAbseitov, E.T."],"author_filter":["kuterbekov, k.a.\n|||\nKuterbekov, K.A.","balapanov, m. kh.\n|||\nBalapanov, M. Kh.","kubenova, m.m.\n|||\nKubenova, M.M.","ishembetov, r. kh.\n|||\nIshembetov, R. Kh.","zeleev, m. kh.\n|||\nZeleev, M. Kh.","yakshibaev, r.a.\n|||\nYakshibaev, R.A.","kabyshev, a.m.\n|||\nKabyshev, A.M.","alina, r.a.\n|||\nAlina, R.A.","bekmyrza, k. zh.\n|||\nBekmyrza, K. Zh.","baikhozhaeva, b.u.\n|||\nBaikhozhaeva, B.U.","abseitov, e.t.\n|||\nAbseitov, E.T.","abseitov, e.t.\n|||\nAbseitov, E.T."],"dc.contributor.author_hl":["Kuterbekov, K.A.","Balapanov, M. Kh.","Kubenova, M.M.","Ishembetov, R. Kh.","Zeleev, M. Kh.","Yakshibaev, R.A.","Kabyshev, A.M.","Alina, R.A.","Bekmyrza, K. Zh.","Baikhozhaeva, B.U.","Abseitov, E.T.","Abseitov, E.T."],"dc.contributor.author_mlt":["Kuterbekov, K.A.","Balapanov, M. Kh.","Kubenova, M.M.","Ishembetov, R. Kh.","Zeleev, M. Kh.","Yakshibaev, R.A.","Kabyshev, A.M.","Alina, R.A.","Bekmyrza, K. Zh.","Baikhozhaeva, B.U.","Abseitov, E.T.","Abseitov, E.T."],"dc.contributor.author":["Kuterbekov, K.A.","Balapanov, M. Kh.","Kubenova, M.M.","Ishembetov, R. Kh.","Zeleev, M. Kh.","Yakshibaev, R.A.","Kabyshev, A.M.","Alina, R.A.","Bekmyrza, K. Zh.","Baikhozhaeva, B.U.","Abseitov, E.T.","Abseitov, E.T."],"dc.contributor.author_stored":["Kuterbekov, K.A.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Balapanov, M. Kh.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Kubenova, M.M.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Ishembetov, R. Kh.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Zeleev, M. Kh.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Yakshibaev, R.A.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Kabyshev, A.M.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Alina, R.A.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Bekmyrza, K. Zh.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Baikhozhaeva, B.U.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Abseitov, E.T.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Abseitov, E.T.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen"],"dc.contributor.author.en":["Kuterbekov, K.A.","Balapanov, M. Kh.","Kubenova, M.M.","Ishembetov, R. Kh.","Zeleev, M. Kh.","Yakshibaev, R.A.","Kabyshev, A.M.","Alina, R.A.","Bekmyrza, K. Zh.","Baikhozhaeva, B.U.","Abseitov, E.T.","Abseitov, E.T."],"dc.date.accessioned_dt":"2022-09-28T07:30:14Z","dc.date.accessioned":["2022-09-28T07:30:14Z"],"dc.date.available":["2022-09-28T07:30:14Z"],"dateIssued":["2022-01-01"],"dateIssued_keyword":["2022-01-01","2022"],"dateIssued_ac":["2022-01-01\n|||\n2022-01-01","2022"],"dateIssued.year":[2022],"dateIssued.year_sort":"2022","dc.date.issued_dt":"2022-01-01T00:00:00Z","dc.date.issued":["2022-01-01"],"dc.date.issued_stored":["2022-01-01\n|||\nnull\n|||\nnull\n|||\nnull\n|||\n"],"dc.description.abstract_hl":["The paper presents the experimental results on ionic conductivity and chemical diffusion in nonstoichiometric nanocrystalline superionic materials NaxCu1.75S (x = 0.1, 0.15, 0.2, 25). High values of the coefficient of conjugated chemical diffusion of cations and electronic holes (1.1∙10−3 and 1.65∙10−3 cm2/s at 410 °C) were observed in the studied electron-ionic conductors Na0.10Cu1.75S and Na0.20Cu1.75S. Activation energies of the total ionic conductivity are measured as 0.30 and 0.40 eV for superionic Na0.10Cu1.75S and Na0.15Cu1.75S phases respectively. In the superionic phases, the measured values of the total ionic conductivity are 2.8, 1.5, and 2.0 S/cm for Na0.10Cu1.75S, Na0.15Cu1.75S, and Na0.20Cu1.75S at 410 °C respectively. Thus, insertion of sodium to copper sulfide did not lead to worse of high ionic conductivity in the superionic phase. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature."],"dc.description.abstract":["The paper presents the experimental results on ionic conductivity and chemical diffusion in nonstoichiometric nanocrystalline superionic materials NaxCu1.75S (x = 0.1, 0.15, 0.2, 25). High values of the coefficient of conjugated chemical diffusion of cations and electronic holes (1.1∙10−3 and 1.65∙10−3 cm2/s at 410 °C) were observed in the studied electron-ionic conductors Na0.10Cu1.75S and Na0.20Cu1.75S. Activation energies of the total ionic conductivity are measured as 0.30 and 0.40 eV for superionic Na0.10Cu1.75S and Na0.15Cu1.75S phases respectively. In the superionic phases, the measured values of the total ionic conductivity are 2.8, 1.5, and 2.0 S/cm for Na0.10Cu1.75S, Na0.15Cu1.75S, and Na0.20Cu1.75S at 410 °C respectively. Thus, insertion of sodium to copper sulfide did not lead to worse of high ionic conductivity in the superionic phase. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature."],"dc.description.abstract.en":["The paper presents the experimental results on ionic conductivity and chemical diffusion in nonstoichiometric nanocrystalline superionic materials NaxCu1.75S (x = 0.1, 0.15, 0.2, 25). High values of the coefficient of conjugated chemical diffusion of cations and electronic holes (1.1∙10−3 and 1.65∙10−3 cm2/s at 410 °C) were observed in the studied electron-ionic conductors Na0.10Cu1.75S and Na0.20Cu1.75S. Activation energies of the total ionic conductivity are measured as 0.30 and 0.40 eV for superionic Na0.10Cu1.75S and Na0.15Cu1.75S phases respectively. In the superionic phases, the measured values of the total ionic conductivity are 2.8, 1.5, and 2.0 S/cm for Na0.10Cu1.75S, Na0.15Cu1.75S, and Na0.20Cu1.75S at 410 °C respectively. Thus, insertion of sodium to copper sulfide did not lead to worse of high ionic conductivity in the superionic phase. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature."],"dc.doi":["10.1007/s11581-022-04651-y"],"dc.identifier.issn":["0947-7047"],"dc.identifier.uri":["http://hdl.handle.net/123456789/6951"],"dc.language.iso":["en"],"dc.language.iso.en":["en"],"dc.publisher":["Springer Science and Business Media Deutschland GmbH"],"dc.publisher.en":["Springer Science and Business Media Deutschland GmbH"],"dc.relation.ispartofseries":["Ionics;т. 28 № 9"],"dc.relation.ispartofseries.en":["Ionics;т. 28 № 9"],"subject":["Chemical diffusion","Copper chalcogenides","Ionic conductivity","Superionic materials","Synthesis","scopus","Web of Science"],"subject_keyword":["Chemical diffusion","Chemical diffusion","Copper chalcogenides","Copper chalcogenides","Ionic conductivity","Ionic conductivity","Superionic materials","Superionic materials","Synthesis","Synthesis","scopus","scopus","Web of Science","Web of Science"],"subject_ac":["chemical diffusion\n|||\nChemical diffusion","copper chalcogenides\n|||\nCopper chalcogenides","ionic conductivity\n|||\nIonic conductivity","superionic materials\n|||\nSuperionic materials","synthesis\n|||\nSynthesis","scopus\n|||\nscopus","web of science\n|||\nWeb of Science"],"subject_tax_0_filter":["chemical diffusion\n|||\nChemical diffusion","copper chalcogenides\n|||\nCopper chalcogenides","ionic conductivity\n|||\nIonic conductivity","superionic materials\n|||\nSuperionic materials","synthesis\n|||\nSynthesis","scopus\n|||\nscopus","web of science\n|||\nWeb of Science"],"subject_filter":["chemical diffusion\n|||\nChemical diffusion","copper chalcogenides\n|||\nCopper chalcogenides","ionic conductivity\n|||\nIonic conductivity","superionic materials\n|||\nSuperionic materials","synthesis\n|||\nSynthesis","scopus\n|||\nscopus","web of science\n|||\nWeb of Science"],"dc.subject_mlt":["Chemical diffusion","Copper chalcogenides","Ionic conductivity","Superionic materials","Synthesis","scopus","Web of Science"],"dc.subject":["Chemical diffusion","Copper chalcogenides","Ionic conductivity","Superionic materials","Synthesis","scopus","Web of Science"],"dc.subject.en":["Chemical diffusion","Copper chalcogenides","Ionic conductivity","Superionic materials","Synthesis","scopus","Web of Science"],"title":["Chemical diffusion and ionic conductivity in nonstoichiometric nanocrystalline superionic NaxCu1.75S (x = 0.1, 0.15, 0.2, 0.25) materials"],"title_keyword":["Chemical diffusion and ionic conductivity in nonstoichiometric nanocrystalline superionic NaxCu1.75S (x = 0.1, 0.15, 0.2, 0.25) materials"],"title_ac":["chemical diffusion and ionic conductivity in nonstoichiometric nanocrystalline superionic naxcu1.75s (x = 0.1, 0.15, 0.2, 0.25) materials\n|||\nChemical diffusion and ionic conductivity in nonstoichiometric nanocrystalline superionic NaxCu1.75S (x = 0.1, 0.15, 0.2, 0.25) materials"],"dc.title_sort":"Chemical diffusion and ionic conductivity in nonstoichiometric nanocrystalline superionic NaxCu1.75S (x = 0.1, 0.15, 0.2, 0.25) materials","dc.title_hl":["Chemical diffusion and ionic conductivity in nonstoichiometric nanocrystalline superionic NaxCu1.75S (x = 0.1, 0.15, 0.2, 0.25) materials"],"dc.title_mlt":["Chemical diffusion and ionic conductivity in nonstoichiometric nanocrystalline superionic NaxCu1.75S (x = 0.1, 0.15, 0.2, 0.25) materials"],"dc.title":["Chemical diffusion and ionic conductivity in nonstoichiometric nanocrystalline superionic NaxCu1.75S (x = 0.1, 0.15, 0.2, 0.25) materials"],"dc.title_stored":["Chemical diffusion and ionic conductivity in nonstoichiometric nanocrystalline superionic NaxCu1.75S (x = 0.1, 0.15, 0.2, 0.25) materials\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen"],"dc.title.en":["Chemical diffusion and ionic conductivity in nonstoichiometric nanocrystalline superionic NaxCu1.75S (x = 0.1, 0.15, 0.2, 0.25) materials"],"dc.title.alternative":["Chemical diffusion and ionic conductivity in nonstoichiometric nanocrystalline superionic NaxCu1.75S (x = 0.1, 0.15, 0.2, 0.25) materials"],"dc.title.alternative.en":["Chemical diffusion and ionic conductivity in nonstoichiometric nanocrystalline superionic NaxCu1.75S (x = 0.1, 0.15, 0.2, 0.25) materials"],"dc.type":["Article"],"dc.type.en":["Article"],"publication_grp":["123456789/6951"],"bi_2_dis_filter":["ishembetov, r. kh.\n|||\nIshembetov, R. Kh.","balapanov, m. kh.\n|||\nBalapanov, M. Kh.","kabyshev, a.m.\n|||\nKabyshev, A.M.","alina, r.a.\n|||\nAlina, R.A.","abseitov, e.t.\n|||\nAbseitov, E.T.","yakshibaev, r.a.\n|||\nYakshibaev, R.A.","kubenova, m.m.\n|||\nKubenova, M.M.","zeleev, m. kh.\n|||\nZeleev, M. Kh.","kuterbekov, k.a.\n|||\nKuterbekov, K.A.","bekmyrza, k. zh.\n|||\nBekmyrza, K. Zh.","baikhozhaeva, b.u.\n|||\nBaikhozhaeva, B.U."],"bi_2_dis_partial":["Abseitov, E.T.","Kuterbekov, K.A.","Baikhozhaeva, B.U.","Alina, R.A.","Kabyshev, A.M.","Zeleev, M. Kh.","Bekmyrza, K. Zh.","Kubenova, M.M.","Balapanov, M. Kh.","Ishembetov, R. Kh.","Yakshibaev, R.A."],"bi_2_dis_value_filter":["Abseitov, E.T.","Kuterbekov, K.A.","Baikhozhaeva, B.U.","Alina, R.A.","Kabyshev, A.M.","Zeleev, M. Kh.","Bekmyrza, K. Zh.","Kubenova, M.M.","Balapanov, M. Kh.","Ishembetov, R. Kh.","Yakshibaev, R.A."],"bi_4_dis_filter":["ionic conductivity\n|||\nIonic conductivity","superionic materials\n|||\nSuperionic materials","chemical diffusion\n|||\nChemical diffusion","scopus\n|||\nscopus","copper chalcogenides\n|||\nCopper chalcogenides","synthesis\n|||\nSynthesis","web of science\n|||\nWeb of Science"],"bi_4_dis_partial":["Web of Science","Synthesis","Ionic conductivity","Chemical diffusion","scopus","Superionic materials","Copper chalcogenides"],"bi_4_dis_value_filter":["Web of Science","Synthesis","Ionic conductivity","Chemical diffusion","scopus","Superionic materials","Copper chalcogenides"],"bi_sort_1_sort":"chemical diffusion and ionic conductivity in nonstoichiometric nanocrystalline superionic naxcu1.75s (x = 0.1, 0.15, 0.2, 0.25) materials","bi_sort_2_sort":"2022","bi_sort_3_sort":"2022-09-28T07:30:14Z","read":["g0"],"_version_":1749817443285467136},{"SolrIndexer.lastIndexed":"2023-10-12T06:52:21.324Z","search.uniqueid":"2-6962","search.resourcetype":2,"search.resourceid":6962,"handle":"123456789/7840","location":["m229","l684"],"location.comm":["229"],"location.coll":["684"],"withdrawn":"false","discoverable":"true","author":["Wu, Hongjie","Beylerli, Ozal","Gareev, Ilgiz","Beilerli, Aferin","Ilyasova, Tatiana","Talybov, Rustam","Sufianov, Albert","Guo, Xiaolong"],"author_keyword":["Wu, Hongjie","Beylerli, Ozal","Gareev, Ilgiz","Beilerli, Aferin","Ilyasova, Tatiana","Talybov, Rustam","Sufianov, Albert","Guo, Xiaolong"],"author_ac":["wu, hongjie\n|||\nWu, Hongjie","beylerli, ozal\n|||\nBeylerli, Ozal","gareev, ilgiz\n|||\nGareev, Ilgiz","beilerli, aferin\n|||\nBeilerli, Aferin","ilyasova, tatiana\n|||\nIlyasova, Tatiana","talybov, rustam\n|||\nTalybov, Rustam","sufianov, albert\n|||\nSufianov, Albert","guo, xiaolong\n|||\nGuo, Xiaolong"],"author_filter":["wu, hongjie\n|||\nWu, Hongjie","beylerli, ozal\n|||\nBeylerli, Ozal","gareev, ilgiz\n|||\nGareev, Ilgiz","beilerli, aferin\n|||\nBeilerli, Aferin","ilyasova, tatiana\n|||\nIlyasova, Tatiana","talybov, rustam\n|||\nTalybov, Rustam","sufianov, albert\n|||\nSufianov, Albert","guo, xiaolong\n|||\nGuo, Xiaolong"],"dc.contributor.author_hl":["Wu, Hongjie","Beylerli, Ozal","Gareev, Ilgiz","Beilerli, Aferin","Ilyasova, Tatiana","Talybov, Rustam","Sufianov, Albert","Guo, Xiaolong"],"dc.contributor.author_mlt":["Wu, Hongjie","Beylerli, Ozal","Gareev, Ilgiz","Beilerli, Aferin","Ilyasova, Tatiana","Talybov, Rustam","Sufianov, Albert","Guo, Xiaolong"],"dc.contributor.author":["Wu, Hongjie","Beylerli, Ozal","Gareev, Ilgiz","Beilerli, Aferin","Ilyasova, Tatiana","Talybov, Rustam","Sufianov, Albert","Guo, Xiaolong"],"dc.contributor.author_stored":["Wu, Hongjie\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Beylerli, Ozal\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Gareev, Ilgiz\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Beilerli, Aferin\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Ilyasova, Tatiana\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Talybov, Rustam\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Sufianov, Albert\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Guo, Xiaolong\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen"],"dc.contributor.author.en":["Wu, Hongjie","Beylerli, Ozal","Gareev, Ilgiz","Beilerli, Aferin","Ilyasova, Tatiana","Talybov, Rustam","Sufianov, Albert","Guo, Xiaolong"],"dc.date.accessioned_dt":"2023-10-12T06:51:15Z","dc.date.accessioned":["2023-10-12T06:51:15Z"],"dc.date.available":["2023-10-12T06:51:15Z"],"dateIssued":["2023-01-01"],"dateIssued_keyword":["2023-01-01","2023"],"dateIssued_ac":["2023-01-01\n|||\n2023-01-01","2023"],"dateIssued.year":[2023],"dateIssued.year_sort":"2023","dc.date.issued_dt":"2023-01-01T00:00:00Z","dc.date.issued":["2023-01-01"],"dc.date.issued_stored":["2023-01-01\n|||\nnull\n|||\nnull\n|||\nnull\n|||\n"],"dc.description.abstract_hl":["Intracranial meningiomas are the most common tumors of the central nervous system (CNS). Meningiomas account for up to 36% of all brain tumors. The incidence of metastatic brain lesions has not been determined. Up to 30% of adult patients with cancer of one localization or another suffer from a secondary tumor lesion of the brain. The vast majority of meningiomas have meningeal localization; >90% are solitary. The incidence of intracranial dural metastases (IDM) is 8-9% of cases, while in 10% of cases, the brain is the only localization, and in 50% of cases the metastases are solitary. Typically, the task of distinguishing between meningioma and dural metastasis does not involve difficul- ties. Periodically, there is a situation when the differential diagnosis between these tumors is ambiguous, since menin- giomas and solitary IDM may have similar characteristics, in particular, a cavity-less solid structure, limited diffusion of water molecules, the presence of extensive peritumoral edema, and an identical contrast pattern. The present study included 100 patients with newly diagnosed tumors of the CNS, who subsequently underwent examination and neurosurgical treat- ment at the Federal Center for Neurosurgery with histological verification between May 2019 and October 2022. Depending on the histological conclusion, two study groups of patients were distinguished: The first group consisted of patients diag- nosed with intracranial meningiomas (n=50) and the second group of patients were diagnosed with IDM (n=50). The study was performed using a magnetic resonance imaging (MRI) General Electric Discovery W750 3T before and after contrast enhancement. The diagnostic value of this study was estimated using Receiver Operating Characteristic curve and area under the curve analysis. Based on the results of the study, it was found that the use of multiparametric MRI (mpMRI) in the differential diagnosis of intracranial meningiomas and IDM was limited by the similarity of the values of the measured diffusion coefficient. The assumption, previously put forward in the literature, regarding the presence of a statistically significant difference in the apparent diffusion coefficient values, which make it possible to differentiate tumors, was not confirmed. When analyzing perfusion data, IDM showed higher cerebral blood flow (CBF) values compared with intracranial meningiomas (P≤0.001). A threshold value of the CBF index was revealed, which was 217.9 ml/100 g/min, above which it is possible to predict IDM with a sensitivity and specificity of 80.0 and 86.0%, respectively. Diffusion-weighted images are not reliable criteria for differentiating intracranial meningiomas from IDM and should not influence the diag- nosis suggested by imaging. The technique for assessing the perfusion of a meningeal lesion makes it possible to predict metastases with a sensitivity and specificity close to 80-90% and deserves attention when making a diagnosis. In the future, in order to reduce the number of false negative and false positive results, mpMRI would require additional criteria to be included in the protocol. Since IDM differs from intra- cranial meningiomas in the severity of neoangiogenesis and, accordingly, in greater vascular permeability, the technique for assessing vascular permeability (wash-in parameter with dynamic contrast enhancement) may serve as a refining crite- rion for distinguishing between dural lesions. © 2023 Spandidos Publications. All rights reserved."],"dc.description.abstract":["Intracranial meningiomas are the most common tumors of the central nervous system (CNS). Meningiomas account for up to 36% of all brain tumors. The incidence of metastatic brain lesions has not been determined. Up to 30% of adult patients with cancer of one localization or another suffer from a secondary tumor lesion of the brain. The vast majority of meningiomas have meningeal localization; >90% are solitary. The incidence of intracranial dural metastases (IDM) is 8-9% of cases, while in 10% of cases, the brain is the only localization, and in 50% of cases the metastases are solitary. Typically, the task of distinguishing between meningioma and dural metastasis does not involve difficul- ties. Periodically, there is a situation when the differential diagnosis between these tumors is ambiguous, since menin- giomas and solitary IDM may have similar characteristics, in particular, a cavity-less solid structure, limited diffusion of water molecules, the presence of extensive peritumoral edema, and an identical contrast pattern. The present study included 100 patients with newly diagnosed tumors of the CNS, who subsequently underwent examination and neurosurgical treat- ment at the Federal Center for Neurosurgery with histological verification between May 2019 and October 2022. Depending on the histological conclusion, two study groups of patients were distinguished: The first group consisted of patients diag- nosed with intracranial meningiomas (n=50) and the second group of patients were diagnosed with IDM (n=50). The study was performed using a magnetic resonance imaging (MRI) General Electric Discovery W750 3T before and after contrast enhancement. The diagnostic value of this study was estimated using Receiver Operating Characteristic curve and area under the curve analysis. Based on the results of the study, it was found that the use of multiparametric MRI (mpMRI) in the differential diagnosis of intracranial meningiomas and IDM was limited by the similarity of the values of the measured diffusion coefficient. The assumption, previously put forward in the literature, regarding the presence of a statistically significant difference in the apparent diffusion coefficient values, which make it possible to differentiate tumors, was not confirmed. When analyzing perfusion data, IDM showed higher cerebral blood flow (CBF) values compared with intracranial meningiomas (P≤0.001). A threshold value of the CBF index was revealed, which was 217.9 ml/100 g/min, above which it is possible to predict IDM with a sensitivity and specificity of 80.0 and 86.0%, respectively. Diffusion-weighted images are not reliable criteria for differentiating intracranial meningiomas from IDM and should not influence the diag- nosis suggested by imaging. The technique for assessing the perfusion of a meningeal lesion makes it possible to predict metastases with a sensitivity and specificity close to 80-90% and deserves attention when making a diagnosis. In the future, in order to reduce the number of false negative and false positive results, mpMRI would require additional criteria to be included in the protocol. Since IDM differs from intra- cranial meningiomas in the severity of neoangiogenesis and, accordingly, in greater vascular permeability, the technique for assessing vascular permeability (wash-in parameter with dynamic contrast enhancement) may serve as a refining crite- rion for distinguishing between dural lesions. © 2023 Spandidos Publications. All rights reserved."],"dc.description.abstract.en":["Intracranial meningiomas are the most common tumors of the central nervous system (CNS). Meningiomas account for up to 36% of all brain tumors. The incidence of metastatic brain lesions has not been determined. Up to 30% of adult patients with cancer of one localization or another suffer from a secondary tumor lesion of the brain. The vast majority of meningiomas have meningeal localization; >90% are solitary. The incidence of intracranial dural metastases (IDM) is 8-9% of cases, while in 10% of cases, the brain is the only localization, and in 50% of cases the metastases are solitary. Typically, the task of distinguishing between meningioma and dural metastasis does not involve difficul- ties. Periodically, there is a situation when the differential diagnosis between these tumors is ambiguous, since menin- giomas and solitary IDM may have similar characteristics, in particular, a cavity-less solid structure, limited diffusion of water molecules, the presence of extensive peritumoral edema, and an identical contrast pattern. The present study included 100 patients with newly diagnosed tumors of the CNS, who subsequently underwent examination and neurosurgical treat- ment at the Federal Center for Neurosurgery with histological verification between May 2019 and October 2022. Depending on the histological conclusion, two study groups of patients were distinguished: The first group consisted of patients diag- nosed with intracranial meningiomas (n=50) and the second group of patients were diagnosed with IDM (n=50). The study was performed using a magnetic resonance imaging (MRI) General Electric Discovery W750 3T before and after contrast enhancement. The diagnostic value of this study was estimated using Receiver Operating Characteristic curve and area under the curve analysis. Based on the results of the study, it was found that the use of multiparametric MRI (mpMRI) in the differential diagnosis of intracranial meningiomas and IDM was limited by the similarity of the values of the measured diffusion coefficient. The assumption, previously put forward in the literature, regarding the presence of a statistically significant difference in the apparent diffusion coefficient values, which make it possible to differentiate tumors, was not confirmed. When analyzing perfusion data, IDM showed higher cerebral blood flow (CBF) values compared with intracranial meningiomas (P≤0.001). A threshold value of the CBF index was revealed, which was 217.9 ml/100 g/min, above which it is possible to predict IDM with a sensitivity and specificity of 80.0 and 86.0%, respectively. Diffusion-weighted images are not reliable criteria for differentiating intracranial meningiomas from IDM and should not influence the diag- nosis suggested by imaging. The technique for assessing the perfusion of a meningeal lesion makes it possible to predict metastases with a sensitivity and specificity close to 80-90% and deserves attention when making a diagnosis. In the future, in order to reduce the number of false negative and false positive results, mpMRI would require additional criteria to be included in the protocol. Since IDM differs from intra- cranial meningiomas in the severity of neoangiogenesis and, accordingly, in greater vascular permeability, the technique for assessing vascular permeability (wash-in parameter with dynamic contrast enhancement) may serve as a refining crite- rion for distinguishing between dural lesions. © 2023 Spandidos Publications. All rights reserved."],"dc.doi":["10.3892/ol.2023.13936"],"dc.identifier.issn":["1792-1074"],"dc.identifier.uri":["http://hdl.handle.net/123456789/7840"],"dc.language.iso":["en"],"dc.language.iso.en":["en"],"dc.publisher":["Spandidos Publications"],"dc.publisher.en":["Spandidos Publications"],"dc.relation.ispartofseries":["Oncology Letters;v. 26 № 2"],"dc.relation.ispartofseries.en":["Oncology Letters;v. 26 № 2"],"subject":["biomarkers","diffusion coefficient measurement","intracranial dural metastasis","intracranial meningioma","mpMRI","MR perfusion","neuroimaging","Scopus"],"subject_keyword":["biomarkers","biomarkers","diffusion coefficient measurement","diffusion coefficient measurement","intracranial dural metastasis","intracranial dural metastasis","intracranial meningioma","intracranial meningioma","mpMRI","mpMRI","MR perfusion","MR perfusion","neuroimaging","neuroimaging","Scopus","Scopus"],"subject_ac":["biomarkers\n|||\nbiomarkers","diffusion coefficient measurement\n|||\ndiffusion coefficient measurement","intracranial dural metastasis\n|||\nintracranial dural metastasis","intracranial meningioma\n|||\nintracranial meningioma","mpmri\n|||\nmpMRI","mr perfusion\n|||\nMR perfusion","neuroimaging\n|||\nneuroimaging","scopus\n|||\nScopus"],"subject_tax_0_filter":["biomarkers\n|||\nbiomarkers","diffusion coefficient measurement\n|||\ndiffusion coefficient measurement","intracranial dural metastasis\n|||\nintracranial dural metastasis","intracranial meningioma\n|||\nintracranial meningioma","mpmri\n|||\nmpMRI","mr perfusion\n|||\nMR perfusion","neuroimaging\n|||\nneuroimaging","scopus\n|||\nScopus"],"subject_filter":["biomarkers\n|||\nbiomarkers","diffusion coefficient measurement\n|||\ndiffusion coefficient measurement","intracranial dural metastasis\n|||\nintracranial dural metastasis","intracranial meningioma\n|||\nintracranial meningioma","mpmri\n|||\nmpMRI","mr perfusion\n|||\nMR perfusion","neuroimaging\n|||\nneuroimaging","scopus\n|||\nScopus"],"dc.subject_mlt":["biomarkers","diffusion coefficient measurement","intracranial dural metastasis","intracranial meningioma","mpMRI","MR perfusion","neuroimaging","Scopus"],"dc.subject":["biomarkers","diffusion coefficient measurement","intracranial dural metastasis","intracranial meningioma","mpMRI","MR perfusion","neuroimaging","Scopus"],"dc.subject.en":["biomarkers","diffusion coefficient measurement","intracranial dural metastasis","intracranial meningioma","mpMRI","MR perfusion","neuroimaging","Scopus"],"title":["Are there reliable multiparametric MRI criteria for differential diagnosis between intracranial meningiomas and solitary intracranial dural metastases?"],"title_keyword":["Are there reliable multiparametric MRI criteria for differential diagnosis between intracranial meningiomas and solitary intracranial dural metastases?"],"title_ac":["are there reliable multiparametric mri criteria for differential diagnosis between intracranial meningiomas and solitary intracranial dural metastases?\n|||\nAre there reliable multiparametric MRI criteria for differential diagnosis between intracranial meningiomas and solitary intracranial dural metastases?"],"dc.title_sort":"Are there reliable multiparametric MRI criteria for differential diagnosis between intracranial meningiomas and solitary intracranial dural metastases?","dc.title_hl":["Are there reliable multiparametric MRI criteria for differential diagnosis between intracranial meningiomas and solitary intracranial dural metastases?"],"dc.title_mlt":["Are there reliable multiparametric MRI criteria for differential diagnosis between intracranial meningiomas and solitary intracranial dural metastases?"],"dc.title":["Are there reliable multiparametric MRI criteria for differential diagnosis between intracranial meningiomas and solitary intracranial dural metastases?"],"dc.title_stored":["Are there reliable multiparametric MRI criteria for differential diagnosis between intracranial meningiomas and solitary intracranial dural metastases?\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen"],"dc.title.en":["Are there reliable multiparametric MRI criteria for differential diagnosis between intracranial meningiomas and solitary intracranial dural metastases?"],"dc.title.alternative":["Are there reliable multiparametric MRI criteria for differential diagnosis between intracranial meningiomas and solitary intracranial dural metastases?"],"dc.title.alternative.en":["Are there reliable multiparametric MRI criteria for differential diagnosis between intracranial meningiomas and solitary intracranial dural metastases?"],"dc.type":["Article"],"dc.type.en":["Article"],"publication_grp":["123456789/7840"],"bi_2_dis_filter":["beylerli, ozal\n|||\nBeylerli, Ozal","guo, xiaolong\n|||\nGuo, Xiaolong","beilerli, aferin\n|||\nBeilerli, Aferin","wu, hongjie\n|||\nWu, Hongjie","ilyasova, tatiana\n|||\nIlyasova, Tatiana","talybov, rustam\n|||\nTalybov, Rustam","gareev, ilgiz\n|||\nGareev, Ilgiz","sufianov, albert\n|||\nSufianov, Albert"],"bi_2_dis_partial":["Sufianov, Albert","Beilerli, Aferin","Gareev, Ilgiz","Talybov, Rustam","Guo, Xiaolong","Beylerli, Ozal","Ilyasova, Tatiana","Wu, Hongjie"],"bi_2_dis_value_filter":["Sufianov, Albert","Beilerli, Aferin","Gareev, Ilgiz","Talybov, Rustam","Guo, Xiaolong","Beylerli, Ozal","Ilyasova, Tatiana","Wu, Hongjie"],"bi_4_dis_filter":["diffusion coefficient measurement\n|||\ndiffusion coefficient measurement","intracranial meningioma\n|||\nintracranial meningioma","neuroimaging\n|||\nneuroimaging","biomarkers\n|||\nbiomarkers","scopus\n|||\nScopus","intracranial dural metastasis\n|||\nintracranial dural metastasis","mpmri\n|||\nmpMRI","mr perfusion\n|||\nMR perfusion"],"bi_4_dis_partial":["intracranial dural metastasis","diffusion coefficient measurement","mpMRI","biomarkers","MR perfusion","Scopus","intracranial meningioma","neuroimaging"],"bi_4_dis_value_filter":["intracranial dural metastasis","diffusion coefficient measurement","mpMRI","biomarkers","MR perfusion","Scopus","intracranial meningioma","neuroimaging"],"bi_sort_1_sort":"are there reliable multiparametric mri criteria for differential diagnosis between intracranial meningiomas and solitary intracranial dural metastases?","bi_sort_2_sort":"2023","bi_sort_3_sort":"2023-10-12T06:51:15Z","read":["g0"],"_version_":1779531557197840384},{"SolrIndexer.lastIndexed":"2021-09-28T06:26:33.449Z","search.uniqueid":"2-5240","search.resourcetype":2,"search.resourceid":5240,"handle":"123456789/6150","location":["m229","l684"],"location.comm":["229"],"location.coll":["684"],"withdrawn":"false","discoverable":"true","author":["Sahakyan, H.","Margaryan, A.","Saag, L.","Karmin, M.","Flores, R.","Haber, M.","Kushniarevich, A.","Khachatryan, Z.","Bahmanimehr, A.","Parik, J.","Karafet, T.","Yunusbayev, B.","Reisberg, T.","Solnik, A.","Metspalu, E.","Hovhannisyan, A.","Khusnutdinova, E.K.","Behar, D.M.","Metspalu, M.","Yepiskoposyan, L.","Rootsi, S.","Villems, R."],"author_keyword":["Sahakyan, H.","Margaryan, A.","Saag, L.","Karmin, M.","Flores, R.","Haber, M.","Kushniarevich, A.","Khachatryan, Z.","Bahmanimehr, A.","Parik, J.","Karafet, T.","Yunusbayev, B.","Reisberg, T.","Solnik, A.","Metspalu, E.","Hovhannisyan, A.","Khusnutdinova, E.K.","Behar, D.M.","Metspalu, M.","Yepiskoposyan, L.","Rootsi, S.","Villems, R."],"author_ac":["sahakyan, h.\n|||\nSahakyan, H.","margaryan, a.\n|||\nMargaryan, A.","saag, l.\n|||\nSaag, L.","karmin, m.\n|||\nKarmin, M.","flores, r.\n|||\nFlores, R.","haber, m.\n|||\nHaber, M.","kushniarevich, a.\n|||\nKushniarevich, A.","khachatryan, z.\n|||\nKhachatryan, Z.","bahmanimehr, a.\n|||\nBahmanimehr, A.","parik, j.\n|||\nParik, J.","karafet, t.\n|||\nKarafet, T.","yunusbayev, b.\n|||\nYunusbayev, B.","reisberg, t.\n|||\nReisberg, T.","solnik, a.\n|||\nSolnik, A.","metspalu, e.\n|||\nMetspalu, E.","hovhannisyan, a.\n|||\nHovhannisyan, A.","khusnutdinova, e.k.\n|||\nKhusnutdinova, E.K.","behar, d.m.\n|||\nBehar, D.M.","metspalu, m.\n|||\nMetspalu, M.","yepiskoposyan, l.\n|||\nYepiskoposyan, L.","rootsi, s.\n|||\nRootsi, S.","villems, r.\n|||\nVillems, R."],"author_filter":["sahakyan, h.\n|||\nSahakyan, H.","margaryan, a.\n|||\nMargaryan, A.","saag, l.\n|||\nSaag, L.","karmin, m.\n|||\nKarmin, M.","flores, r.\n|||\nFlores, R.","haber, m.\n|||\nHaber, M.","kushniarevich, a.\n|||\nKushniarevich, A.","khachatryan, z.\n|||\nKhachatryan, Z.","bahmanimehr, a.\n|||\nBahmanimehr, A.","parik, j.\n|||\nParik, J.","karafet, t.\n|||\nKarafet, T.","yunusbayev, b.\n|||\nYunusbayev, B.","reisberg, t.\n|||\nReisberg, T.","solnik, a.\n|||\nSolnik, A.","metspalu, e.\n|||\nMetspalu, E.","hovhannisyan, a.\n|||\nHovhannisyan, A.","khusnutdinova, e.k.\n|||\nKhusnutdinova, E.K.","behar, d.m.\n|||\nBehar, D.M.","metspalu, m.\n|||\nMetspalu, M.","yepiskoposyan, l.\n|||\nYepiskoposyan, L.","rootsi, s.\n|||\nRootsi, S.","villems, r.\n|||\nVillems, R."],"dc.contributor.author_hl":["Sahakyan, H.","Margaryan, A.","Saag, L.","Karmin, M.","Flores, R.","Haber, M.","Kushniarevich, A.","Khachatryan, Z.","Bahmanimehr, A.","Parik, J.","Karafet, T.","Yunusbayev, B.","Reisberg, T.","Solnik, A.","Metspalu, E.","Hovhannisyan, A.","Khusnutdinova, E.K.","Behar, D.M.","Metspalu, M.","Yepiskoposyan, L.","Rootsi, S.","Villems, R."],"dc.contributor.author_mlt":["Sahakyan, H.","Margaryan, A.","Saag, L.","Karmin, M.","Flores, R.","Haber, M.","Kushniarevich, A.","Khachatryan, Z.","Bahmanimehr, A.","Parik, J.","Karafet, T.","Yunusbayev, B.","Reisberg, T.","Solnik, A.","Metspalu, E.","Hovhannisyan, A.","Khusnutdinova, E.K.","Behar, D.M.","Metspalu, M.","Yepiskoposyan, L.","Rootsi, S.","Villems, R."],"dc.contributor.author":["Sahakyan, H.","Margaryan, A.","Saag, L.","Karmin, M.","Flores, R.","Haber, M.","Kushniarevich, A.","Khachatryan, Z.","Bahmanimehr, A.","Parik, J.","Karafet, T.","Yunusbayev, B.","Reisberg, T.","Solnik, A.","Metspalu, E.","Hovhannisyan, A.","Khusnutdinova, E.K.","Behar, D.M.","Metspalu, M.","Yepiskoposyan, L.","Rootsi, S.","Villems, R."],"dc.contributor.author_stored":["Sahakyan, H.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Margaryan, A.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Saag, L.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Karmin, M.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Flores, R.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Haber, M.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Kushniarevich, A.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Khachatryan, Z.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Bahmanimehr, A.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Parik, J.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Karafet, T.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Yunusbayev, B.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Reisberg, T.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Solnik, A.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Metspalu, E.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Hovhannisyan, A.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Khusnutdinova, E.K.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Behar, D.M.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Metspalu, M.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Yepiskoposyan, L.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Rootsi, S.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Villems, R.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen"],"dc.contributor.author.en":["Sahakyan, H.","Margaryan, A.","Saag, L.","Karmin, M.","Flores, R.","Haber, M.","Kushniarevich, A.","Khachatryan, Z.","Bahmanimehr, A.","Parik, J.","Karafet, T.","Yunusbayev, B.","Reisberg, T.","Solnik, A.","Metspalu, E.","Hovhannisyan, A.","Khusnutdinova, E.K.","Behar, D.M.","Metspalu, M.","Yepiskoposyan, L.","Rootsi, S.","Villems, R."],"dc.date.accessioned_dt":"2021-09-28T06:24:14Z","dc.date.accessioned":["2021-09-28T06:24:14Z"],"dc.date.available":["2021-09-28T06:24:14Z"],"dateIssued":["2021-01-01"],"dateIssued_keyword":["2021-01-01","2021"],"dateIssued_ac":["2021-01-01\n|||\n2021-01-01","2021"],"dateIssued.year":[2021],"dateIssued.year_sort":"2021","dc.date.issued_dt":"2021-01-01T00:00:00Z","dc.date.issued":["2021-01-01"],"dc.date.issued_stored":["2021-01-01\n|||\nnull\n|||\nnull\n|||\nnull\n|||\n"],"dc.description.abstract_hl":["Human Y chromosome haplogroup J1-M267 is a common male lineage in West Asia. One high-frequency region—encompassing the Arabian Peninsula, southern Mesopotamia, and the southern Levant—resides ~ 2000 km away from the other one found in the Caucasus. The region between them, although has a lower frequency, nevertheless demonstrates high genetic diversity. Studies associate this haplogroup with the spread of farming from the Fertile Crescent to Europe, the spread of mobile pastoralism in the desert regions of the Arabian Peninsula, the history of the Jews, and the spread of Islam. Here, we study past human male demography in West Asia with 172 high-coverage whole Y chromosome sequences and 889 genotyped samples of haplogroup J1-M267. We show that this haplogroup evolved ~ 20,000 years ago somewhere in northwestern Iran, the Caucasus, the Armenian Highland, and northern Mesopotamia. The major branch—J1a1a1-P58—evolved during the early Holocene ~ 9500 years ago somewhere in the Arabian Peninsula, the Levant, and southern Mesopotamia. Haplogroup J1-M267 expanded during the Chalcolithic, the Bronze Age, and the Iron Age. Most probably, the spread of Afro-Asiatic languages, the spread of mobile pastoralism in the arid zones, or both of these events together explain the distribution of haplogroup J1-M267 we see today in the southern regions of West Asia. © 2021, The Author(s)."],"dc.description.abstract":["Human Y chromosome haplogroup J1-M267 is a common male lineage in West Asia. One high-frequency region—encompassing the Arabian Peninsula, southern Mesopotamia, and the southern Levant—resides ~ 2000 km away from the other one found in the Caucasus. The region between them, although has a lower frequency, nevertheless demonstrates high genetic diversity. Studies associate this haplogroup with the spread of farming from the Fertile Crescent to Europe, the spread of mobile pastoralism in the desert regions of the Arabian Peninsula, the history of the Jews, and the spread of Islam. Here, we study past human male demography in West Asia with 172 high-coverage whole Y chromosome sequences and 889 genotyped samples of haplogroup J1-M267. We show that this haplogroup evolved ~ 20,000 years ago somewhere in northwestern Iran, the Caucasus, the Armenian Highland, and northern Mesopotamia. The major branch—J1a1a1-P58—evolved during the early Holocene ~ 9500 years ago somewhere in the Arabian Peninsula, the Levant, and southern Mesopotamia. Haplogroup J1-M267 expanded during the Chalcolithic, the Bronze Age, and the Iron Age. Most probably, the spread of Afro-Asiatic languages, the spread of mobile pastoralism in the arid zones, or both of these events together explain the distribution of haplogroup J1-M267 we see today in the southern regions of West Asia. © 2021, The Author(s)."],"dc.description.abstract.en":["Human Y chromosome haplogroup J1-M267 is a common male lineage in West Asia. One high-frequency region—encompassing the Arabian Peninsula, southern Mesopotamia, and the southern Levant—resides ~ 2000 km away from the other one found in the Caucasus. The region between them, although has a lower frequency, nevertheless demonstrates high genetic diversity. Studies associate this haplogroup with the spread of farming from the Fertile Crescent to Europe, the spread of mobile pastoralism in the desert regions of the Arabian Peninsula, the history of the Jews, and the spread of Islam. Here, we study past human male demography in West Asia with 172 high-coverage whole Y chromosome sequences and 889 genotyped samples of haplogroup J1-M267. We show that this haplogroup evolved ~ 20,000 years ago somewhere in northwestern Iran, the Caucasus, the Armenian Highland, and northern Mesopotamia. The major branch—J1a1a1-P58—evolved during the early Holocene ~ 9500 years ago somewhere in the Arabian Peninsula, the Levant, and southern Mesopotamia. Haplogroup J1-M267 expanded during the Chalcolithic, the Bronze Age, and the Iron Age. Most probably, the spread of Afro-Asiatic languages, the spread of mobile pastoralism in the arid zones, or both of these events together explain the distribution of haplogroup J1-M267 we see today in the southern regions of West Asia. © 2021, The Author(s)."],"dc.doi":["10.1038/s41598-021-85883-2"],"dc.identifier.issn":["2045-2322"],"dc.identifier.uri":["http://hdl.handle.net/123456789/6150"],"dc.language.iso":["en"],"dc.language.iso.en":["en"],"dc.publisher":["Nature Research"],"dc.publisher.en":["Nature Research"],"dc.relation.ispartofseries":["Scientific Reports;т. 11 № 1"],"dc.relation.ispartofseries.en":["Scientific Reports;т. 11 № 1"],"subject":["Scopus","adult","agricultural worker","article","Bronze Age","Chalcolithic","demography","desert","diffusion","Europe","Holocene","human"],"subject_keyword":["Scopus","Scopus","adult","adult","agricultural worker","agricultural worker","article","article","Bronze Age","Bronze Age","Chalcolithic","Chalcolithic","demography","demography","desert","desert","diffusion","diffusion","Europe","Europe","Holocene","Holocene","human","human"],"subject_ac":["scopus\n|||\nScopus","adult\n|||\nadult","agricultural worker\n|||\nagricultural worker","article\n|||\narticle","bronze age\n|||\nBronze Age","chalcolithic\n|||\nChalcolithic","demography\n|||\ndemography","desert\n|||\ndesert","diffusion\n|||\ndiffusion","europe\n|||\nEurope","holocene\n|||\nHolocene","human\n|||\nhuman"],"subject_tax_0_filter":["scopus\n|||\nScopus","adult\n|||\nadult","agricultural worker\n|||\nagricultural worker","article\n|||\narticle","bronze age\n|||\nBronze Age","chalcolithic\n|||\nChalcolithic","demography\n|||\ndemography","desert\n|||\ndesert","diffusion\n|||\ndiffusion","europe\n|||\nEurope","holocene\n|||\nHolocene","human\n|||\nhuman"],"subject_filter":["scopus\n|||\nScopus","adult\n|||\nadult","agricultural worker\n|||\nagricultural worker","article\n|||\narticle","bronze age\n|||\nBronze Age","chalcolithic\n|||\nChalcolithic","demography\n|||\ndemography","desert\n|||\ndesert","diffusion\n|||\ndiffusion","europe\n|||\nEurope","holocene\n|||\nHolocene","human\n|||\nhuman"],"dc.subject_mlt":["Scopus","adult","agricultural worker","article","Bronze Age","Chalcolithic","demography","desert","diffusion","Europe","Holocene","human"],"dc.subject":["Scopus","adult","agricultural worker","article","Bronze Age","Chalcolithic","demography","desert","diffusion","Europe","Holocene","human"],"dc.subject.en":["Scopus","adult","agricultural worker","article","Bronze Age","Chalcolithic","demography","desert","diffusion","Europe","Holocene","human"],"title":["Origin and diffusion of human Y chromosome haplogroup J1-M267"],"title_keyword":["Origin and diffusion of human Y chromosome haplogroup J1-M267"],"title_ac":["origin and diffusion of human y chromosome haplogroup j1-m267\n|||\nOrigin and diffusion of human Y chromosome haplogroup J1-M267"],"dc.title_sort":"Origin and diffusion of human Y chromosome haplogroup J1-M267","dc.title_hl":["Origin and diffusion of human Y chromosome haplogroup J1-M267"],"dc.title_mlt":["Origin and diffusion of human Y chromosome haplogroup J1-M267"],"dc.title":["Origin and diffusion of human Y chromosome haplogroup J1-M267"],"dc.title_stored":["Origin and diffusion of human Y chromosome haplogroup J1-M267\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen"],"dc.title.en":["Origin and diffusion of human Y chromosome haplogroup J1-M267"],"dc.title.alternative":["Origin and diffusion of human Y chromosome haplogroup J1-M267"],"dc.title.alternative.en":["Origin and diffusion of human Y chromosome haplogroup J1-M267"],"dc.type":["Article"],"dc.type.en":["Article"],"publication_grp":["123456789/6150"],"bi_2_dis_filter":["sahakyan, h.\n|||\nSahakyan, H.","hovhannisyan, a.\n|||\nHovhannisyan, A.","villems, r.\n|||\nVillems, R.","solnik, a.\n|||\nSolnik, A.","karafet, t.\n|||\nKarafet, T.","rootsi, s.\n|||\nRootsi, S.","khachatryan, z.\n|||\nKhachatryan, Z.","yunusbayev, b.\n|||\nYunusbayev, B.","metspalu, m.\n|||\nMetspalu, M.","flores, r.\n|||\nFlores, R.","saag, l.\n|||\nSaag, L.","kushniarevich, a.\n|||\nKushniarevich, A.","reisberg, t.\n|||\nReisberg, T.","behar, d.m.\n|||\nBehar, D.M.","haber, m.\n|||\nHaber, M.","bahmanimehr, a.\n|||\nBahmanimehr, A.","metspalu, e.\n|||\nMetspalu, E.","yepiskoposyan, l.\n|||\nYepiskoposyan, L.","margaryan, a.\n|||\nMargaryan, A.","parik, j.\n|||\nParik, J.","karmin, m.\n|||\nKarmin, M.","khusnutdinova, e.k.\n|||\nKhusnutdinova, E.K."],"bi_2_dis_partial":["Sahakyan, H.","Hovhannisyan, A.","Khachatryan, Z.","Haber, M.","Yunusbayev, B.","Khusnutdinova, E.K.","Karmin, M.","Margaryan, A.","Kushniarevich, A.","Rootsi, S.","Villems, R.","Reisberg, T.","Solnik, A.","Saag, L.","Metspalu, E.","Bahmanimehr, A.","Karafet, T.","Flores, R.","Behar, D.M.","Metspalu, M.","Parik, J.","Yepiskoposyan, L."],"bi_2_dis_value_filter":["Sahakyan, H.","Hovhannisyan, A.","Khachatryan, Z.","Haber, M.","Yunusbayev, B.","Khusnutdinova, E.K.","Karmin, M.","Margaryan, A.","Kushniarevich, A.","Rootsi, S.","Villems, R.","Reisberg, T.","Solnik, A.","Saag, L.","Metspalu, E.","Bahmanimehr, A.","Karafet, T.","Flores, R.","Behar, D.M.","Metspalu, M.","Parik, J.","Yepiskoposyan, L."],"bi_4_dis_filter":["agricultural worker\n|||\nagricultural worker","chalcolithic\n|||\nChalcolithic","adult\n|||\nadult","article\n|||\narticle","diffusion\n|||\ndiffusion","human\n|||\nhuman","desert\n|||\ndesert","scopus\n|||\nScopus","europe\n|||\nEurope","bronze age\n|||\nBronze Age","demography\n|||\ndemography","holocene\n|||\nHolocene"],"bi_4_dis_partial":["diffusion","demography","Scopus","Europe","agricultural worker","adult","desert","Chalcolithic","Holocene","human","article","Bronze Age"],"bi_4_dis_value_filter":["diffusion","demography","Scopus","Europe","agricultural worker","adult","desert","Chalcolithic","Holocene","human","article","Bronze Age"],"bi_sort_1_sort":"origin and diffusion of human y chromosome haplogroup j1-m267","bi_sort_2_sort":"2021","bi_sort_3_sort":"2021-09-28T06:24:14Z","read":["g0"],"_version_":1712125791132712960}]},"facet_counts":{"facet_queries":{},"facet_fields":{},"facet_dates":{},"facet_ranges":{},"facet_intervals":{}},"highlighting":{"2-8043":{"dc.title.en":["Systemic Benign Lipomatosis (Madelung’s Disease): Experience of Surgical Treatment. Clinical Case"],"dc.title":["Systemic Benign Lipomatosis (Madelung’s Disease): Experience of Surgical Treatment. Clinical Case"],"dc.title_hl":["Systemic Benign Lipomatosis (Madelung’s Disease): Experience of Surgical Treatment. Clinical Case"],"dc.title_mlt":["Systemic Benign Lipomatosis (Madelung’s Disease): Experience of Surgical Treatment. Clinical Case"],"bi_4_dis_partial":["diffuse symmetric lipomatosis"],"dc.subject.en":["diffuse symmetric lipomatosis"],"title":["Systemic Benign Lipomatosis (Madelung’s Disease): Experience of Surgical Treatment. Clinical Case"],"dc.citation.en":["Sia K.J., Tang I.P., Tan T.Y. Multiple symmetrical lipomatosis: case report and literature review"],"dc.subject":["diffuse symmetric lipomatosis"],"dc.citation.ru":["Sia K.J., Tang I.P., Tan T.Y. Multiple symmetrical lipomatosis: case report and literature review"],"dc.subject_mlt":["diffuse symmetric lipomatosis"],"dc.abstract.en":["

Introduction. Diffuse symmetric lipomatosis (Madelung’s disease) is a rare"],"dc.citation":["Sia K.J., Tang I.P., Tan T.Y. Multiple symmetrical lipomatosis: case report and literature review"],"subject":["diffuse symmetric lipomatosis"],"dc.abstract":["

Introduction. Diffuse symmetric lipomatosis (Madelung’s disease) is a rare"]},"2-3923":{"dc.title.en":["Design and Optimization of Plasmon Resonance Sensor Based on Micro-Nano Symmetrical Localized"],"dc.description.abstract":[". Symmetrical design enables high-low concentration of dual-channel distributed sensing. As the fixed light"],"dc.title":["Design and Optimization of Plasmon Resonance Sensor Based on Micro-Nano Symmetrical Localized"],"dc.title_hl":["Design and Optimization of Plasmon Resonance Sensor Based on Micro-Nano Symmetrical Localized"],"dc.title_mlt":["Design and Optimization of Plasmon Resonance Sensor Based on Micro-Nano Symmetrical Localized"],"dc.description.abstract.en":[". Symmetrical design enables high-low concentration of dual-channel distributed sensing. As the fixed light"],"dc.title.alternative.en":["Design and Optimization of Plasmon Resonance Sensor Based on Micro-Nano Symmetrical Localized"],"title":["Design and Optimization of Plasmon Resonance Sensor Based on Micro-Nano Symmetrical Localized"],"dc.description.abstract_hl":[". Symmetrical design enables high-low concentration of dual-channel distributed sensing. As the fixed light"],"dc.title.alternative":["Design and Optimization of Plasmon Resonance Sensor Based on Micro-Nano Symmetrical Localized"]},"2-7244":{"dc.title.en":["The Diffusion Stability of an Externally Driven Cavitation Bubble in Micro-Confinement"],"dc.description.abstract":["Abstract: The diffusion stability of a single cavitation bubble in a spherical liquid cell"],"dc.title":["The Diffusion Stability of an Externally Driven Cavitation Bubble in Micro-Confinement"],"dc.title_hl":["The Diffusion Stability of an Externally Driven Cavitation Bubble in Micro-Confinement"],"dc.title_mlt":["The Diffusion Stability of an Externally Driven Cavitation Bubble in Micro-Confinement"],"bi_4_dis_partial":["diffusion"],"dc.description.abstract.en":["Abstract: The diffusion stability of a single cavitation bubble in a spherical liquid cell"],"dc.subject.en":["diffusion"],"dc.title.alternative.en":["The Diffusion Stability of an Externally Driven Cavitation Bubble in Micro-Confinement"],"title":["The Diffusion Stability of an Externally Driven Cavitation Bubble in Micro-Confinement"],"dc.description.abstract_hl":["Abstract: The diffusion stability of a single cavitation bubble in a spherical liquid cell"],"dc.subject":["diffusion"],"dc.subject_mlt":["diffusion"],"subject":["diffusion"],"dc.title.alternative":["The Diffusion Stability of an Externally Driven Cavitation Bubble in Micro-Confinement"]},"2-6022":{"bi_4_dis_partial":["lipomatosis"],"dc.subject.en":["lipomatosis"],"dc.subject":["lipomatosis"],"dc.subject_mlt":["lipomatosis"],"dc.abstract.en":[" neoplasia. In addition, multiple lipomas are specific manifestations of Madelung or Dercum lipomatosis"],"subject":["lipomatosis"],"dc.abstract":[" neoplasia. In addition, multiple lipomas are specific manifestations of Madelung or Dercum lipomatosis"]},"2-5665":{"dc.title.en":["Lyapunov Quantities for Andronov-Hopf Bifurcation Problem in Reaction-Diffusion Systems"],"dc.description.abstract":[" for the Lyapunov quantity in terms of the original equations is proposed. The ''reaction-diffusion'' equation in a"],"dc.title":["Lyapunov Quantities for Andronov-Hopf Bifurcation Problem in Reaction-Diffusion Systems"],"dc.title_hl":["Lyapunov Quantities for Andronov-Hopf Bifurcation Problem in Reaction-Diffusion Systems"],"dc.title_mlt":["Lyapunov Quantities for Andronov-Hopf Bifurcation Problem in Reaction-Diffusion Systems"],"bi_4_dis_partial":["reaction-diffusion equation"],"dc.description.abstract.en":[" for the Lyapunov quantity in terms of the original equations is proposed. The ''reaction-diffusion'' equation in a"],"dc.subject.en":["reaction-diffusion equation"],"dc.title.alternative.en":["Lyapunov Quantities for Andronov-Hopf Bifurcation Problem in Reaction-Diffusion Systems"],"title":["Lyapunov Quantities for Andronov-Hopf Bifurcation Problem in Reaction-Diffusion Systems"],"dc.description.abstract_hl":[" for the Lyapunov quantity in terms of the original equations is proposed. The ''reaction-diffusion'' equation in a"],"dc.subject":["reaction-diffusion equation"],"dc.subject_mlt":["reaction-diffusion equation"],"subject":["reaction-diffusion equation"],"dc.title.alternative":["Lyapunov Quantities for Andronov-Hopf Bifurcation Problem in Reaction-Diffusion Systems"]},"2-6051":{"dc.description.abstract":[">A (p.Y2285*) with endocrine disorders. The manifestations of NF1, similar to lipomatosis and Jaffe"],"bi_4_dis_partial":["lipomatosis"],"dc.description.abstract.en":[">A (p.Y2285*) with endocrine disorders. The manifestations of NF1, similar to lipomatosis and Jaffe"],"dc.subject.en":["lipomatosis"],"dc.description.abstract_hl":[">A (p.Y2285*) with endocrine disorders. The manifestations of NF1, similar to lipomatosis and Jaffe"],"dc.subject":["lipomatosis"],"dc.subject_mlt":["lipomatosis"],"subject":["lipomatosis"]},"2-7779":{"dc.description.abstract":[" the Fokker–Planck equation to show that rotational diffusion is described by the effective mean field"],"bi_4_dis_partial":["rotational diffusion"],"dc.description.abstract.en":[" the Fokker–Planck equation to show that rotational diffusion is described by the effective mean field"],"dc.subject.en":["rotational diffusion"],"dc.description.abstract_hl":[" the Fokker–Planck equation to show that rotational diffusion is described by the effective mean field"],"dc.subject":["rotational diffusion"],"dc.subject_mlt":["rotational diffusion"],"subject":["rotational diffusion"]},"2-6046":{"dc.title.en":["Chemical diffusion and ionic conductivity in nonstoichiometric nanocrystalline superionic NaxCu1"],"dc.description.abstract":["The paper presents the experimental results on ionic conductivity and chemical diffusion"],"dc.title":["Chemical diffusion and ionic conductivity in nonstoichiometric nanocrystalline superionic NaxCu1"],"dc.title_hl":["Chemical diffusion and ionic conductivity in nonstoichiometric nanocrystalline superionic NaxCu1"],"dc.title_mlt":["Chemical diffusion and ionic conductivity in nonstoichiometric nanocrystalline superionic NaxCu1"],"bi_4_dis_partial":["Chemical diffusion"],"dc.description.abstract.en":["The paper presents the experimental results on ionic conductivity and chemical diffusion"],"dc.subject.en":["Chemical diffusion"],"dc.title.alternative.en":["Chemical diffusion and ionic conductivity in nonstoichiometric nanocrystalline superionic NaxCu1"],"title":["Chemical diffusion and ionic conductivity in nonstoichiometric nanocrystalline superionic NaxCu1"],"dc.description.abstract_hl":["The paper presents the experimental results on ionic conductivity and chemical diffusion"],"dc.subject":["Chemical diffusion"],"dc.subject_mlt":["Chemical diffusion"],"subject":["Chemical diffusion"],"dc.title.alternative":["Chemical diffusion and ionic conductivity in nonstoichiometric nanocrystalline superionic NaxCu1"]},"2-6962":{"dc.description.abstract":[" diffusion of water molecules, the presence of extensive peritumoral edema, and an identical contrast pattern"],"bi_4_dis_partial":["diffusion coefficient measurement"],"dc.description.abstract.en":[" diffusion of water molecules, the presence of extensive peritumoral edema, and an identical contrast pattern"],"dc.subject.en":["diffusion coefficient measurement"],"dc.description.abstract_hl":[" diffusion of water molecules, the presence of extensive peritumoral edema, and an identical contrast pattern"],"dc.subject":["diffusion coefficient measurement"],"dc.subject_mlt":["diffusion coefficient measurement"],"subject":["diffusion coefficient measurement"]},"2-5240":{"dc.title.en":["Origin and diffusion of human Y chromosome haplogroup J1-M267"],"dc.title":["Origin and diffusion of human Y chromosome haplogroup J1-M267"],"dc.title_hl":["Origin and diffusion of human Y chromosome haplogroup J1-M267"],"dc.title_mlt":["Origin and diffusion of human Y chromosome haplogroup J1-M267"],"bi_4_dis_partial":["diffusion"],"dc.subject.en":["diffusion"],"dc.title.alternative.en":["Origin and diffusion of human Y chromosome haplogroup J1-M267"],"title":["Origin and diffusion of human Y chromosome haplogroup J1-M267"],"dc.subject":["diffusion"],"dc.subject_mlt":["diffusion"],"subject":["diffusion"],"dc.title.alternative":["Origin and diffusion of human Y chromosome haplogroup J1-M267"]}}} -->