of atherosclerosis is physical activity, the mechanisms of which are not fully understood. Experimental models have

that an important trigger mechanism for it is the pathological activation of retroelements during aging, leading

species-specific activations of retroelements in successive cell divisions. Evolutionary selection

in cis and in trans. A number of studies have shown that activation of retroelements in neuronal stem

determined the activation of retroelements in joint tissues and in peripheral blood of patients

to changes in the transposable elements, which leads to their activation, dysfunction or susceptibility

to trigger FTD by activating specific retroelements. FTD is associated with multiple single nucleotide