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and their anti-inflammatory activities in J774A.1 were evaluated. Among them, derivative 13a was found

-oxidation); and glucuronidation. The complex metabolism of VPA explains the diversity of its active and inactive metabolites

not been solved and continues to be actively studied. One of the important mechanisms for the development

in the inflammatory response, chemokine activity, and immune response. The KEGG analysis identified several pathways

regulation and weakening of activity in conditions of individual-differentiated classes. The content

exhibited in vitro high inhibiting activity against human topoisomerase I.

and their relative antioxidant activity was evaluated by luminol-dependent chemiluminescence measurements.

-thio]acetic acid hydrazide exhibited antidepressant activity that was most pronounced at a dose of 12

Because of the problem to evaluate biological activity in water‑soluble substances in all phases

activity against topoisomerases I and IIα, key cell cycle enzymes. Using flow cytometry, muricadienin

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