Because of the problem to evaluate biological activity in water‑soluble substances in
all phases of preclinical and clinical studies, the research work enabled to develop the
original solvent for poorly soluble compounds based on substances for parenteral
nutrition. The main aim is to examine the impact of the original solvent based on
substances for parenteral nutrition on biological systems exemplified by the hemostatic
system, characterized by sensitivity and variability of the effects in response to any
impact, and its comparison with the solvents that are conventional in pharmacological
research. Experimental work is performed according to the “guidance on preclinical
research of new pharmacological substances” in vitro. The findings show that traditional
solvents at low dosages affect all the researched indicators of the hemostasis system.
The smallest effect in respect of the hemostatic system was characterized by ethanol,
and the most apparent antiaggregational effect was registered with dioxane. 10%
concentration of original blend of lipids made no effect on hemostasis system. Thus,
according to their own findings and experience in application of lipid emulsions as
substances of parenteral nutrition, they can be considered to be an adequate solvent
in all phases of preclinical and clinical studies of new drugs.