G(8344) mutation as the only manifestation of disease in a carrier of myoclonus epilepsy and ragged-red fibers (MERRF) syndrome. Am J Hum Genet. 1993r;52(3):551–6. PMID: 8447321","Мазунин И.О., Володько Н.В., Стариковская Е.Б., Сукерник Р.И. Митохондриальный геном и митохондриальные заболевания человека. Молекулярная биология. 2010;44(5):755–72.","Celentano V., Esposito E., Perrotta S., Giglio M.C., Tarquini R., Luglio G., et al. Madelung disease: report of a case and review of the literature. Acta Chir Belg. 2014;114(6):417–20. PMID: 26021689","Lemaitre M., Chevalier B., Jannin A., Bourry J., Espiard S., Vantyghem M.C. Multiple symmetric and multiple familial lipomatosis. Presse Med. 2021;50(3):104077. DOI: 10.1016/j.lpm.2021.104077","Вецмадян Е.А., Труфанов Г.Е., Рязанов В.В., Мостовая О.Т., Новиков К.В., Карайванов Н.С. Ультразвуковая диагностика липом мягких тканей с использованием методик цветного допплеровского картирования и эластографии. Вестник Российской Военно-медицинской академии. 2012;2(38):43–50.","Богов А.А., Андреев П.С., Филиппов В.Л., Топыркин В.Г. Оперативное лечение болезни Маделунга. Практическая медицина. 2018;16(7-1):90–3.","Уракова Е.В., Нестеров О.В., Ильина Р.Ю., Лексин Р.В. Хирургическая тактика при рецидивирующем липоматозе (болезни Маделунга). Клинический случай. Практическая медицина. 2022;20(6):131–3.","Егай А.А., Тентимишев А.Э., Норматов Р.М., Тян А.С. Хирургическое лечение множественного симметричного липоматоза (болезнь Маделунга), осложненного сдавлением яремных вен с обеих сторон. Преимущества липэктомии перед липосакцией. Научное обозрение. Медицинские науки. 2022;1:5– 10. DOI: 10.17513/srms.1225","Тимербулатов М.В., Шорнина А.С., Лихтер Р.А., Каипов А.Э. Оценка липосакции в структуре абдоминопластики и сочетанной герниоабдоминопластики. Креативная хирургия и онкология. 2023;13(4):278–83. DOI: 10.24060/2076-3093-2023-13-4-278-283","Dang Y., Du X., Ou X., Zheng Q., Xie F. Advances in diagnosis and treatment of Madelung’s deformity. Am J Transl Res. 2023;15(7):4416–24.","Leti Acciaro A, Garagnani L, Lando M, Lana D, Sartini S, Adani R. Modified dome osteotomy and anterior locking plate fixation for distal radius variant of Madelung deformity: a retrospective study. J Plast Surg Hand Surg. 2022;56(2):121–6. DOI: 10.1080/2000656X.2021.1934845","Liu Q., Lyu H., Xu B., Lee J.H. Madelung disease epidemiology and clinical characteristics: a systemic review. Aesthetic Plast Surg. 2021;45(3):977–86. DOI: 10.1007/s00266-020-02083-5","Sia K.J., Tang I.P., Tan T.Y. Multiple symmetrical lipomatosis: case report and literature review. J Laryngol Otol. 2012;126(7):756–8. DOI: 10.1017/S0022215112000709","Kratz C., Lenard H.G., Ruzicka T., Gärtner J. Multiple symmetric lipomatosis: an unusual cause of childhood obesity and mental retardation. Eur J Paediatr Neurol. 2000;4(2):63–7. DOI: 10.1053/ejpn.2000.0264","Nounla J., Rolle U., Gräfe G., Kräling K. Benign symmetric lipomatosis with myelomeningocele in an adolescent: An uncommon association-case report. J Pediatr Surg. 2001;36(7):E13. DOI: 10.1053/jpsu.2001.24776","Madelung O.W. Über den Fetthals (diffuses Lipom des Halses). Arch Klin Chir. 1888;37:106-30.","Lanois P.E., Bensaude R. De ladeno-lipomatosesymetrique. Bull Mem Soc Med Hosp. 1898;1:298.","El Ouahabi H., Doubi S., Lahlou K., Boujraf S., Ajdi F. Launois-bensaude syndrome: A benign symmetric lipomatosis without alcohol association. Ann Afr Med. 2017;16(1):33–4. DOI: 10.4103/1596-3519.202082","Chen C.Y., Fang Q.Q., Wang X.F., Zhang M.X., Zhao W.Y., Shi B.H., et al. Madelung’s disease: lipectomy or liposuction? Biomed Res Int. 2018;3975974. DOI: 10.1155/2018/3975974","Coker J.E., Bryan J.A. Endocrine and metabolic disorders: Causes and pathogenesis of obesity. J. Fam. Pract. 2008;4:21–6.","González-García R., Rodríguez-Campo F.J., Sastre-Pérez J., Muñoz-Guerra M.F. Benign symmetric lipomatosis (Madelung’s disease): case reports and current management. Aesthetic Plast Surg. 2004;28(2):108– 12; discussion 113. DOI: 10.1007/s00266-004-3123-5","Holme E., Larsson N.G., Oldfors A., Tulinius M., Sahlin P., Stenman G. Multiple symmetric lipomas with high levels of mtDNA with the tRNA(Lys) A-->G(8344) mutation as the only manifestation of disease in a carrier of myoclonus epilepsy and ragged-red fibers (MERRF) syndrome. Am J Hum Genet. 1993r;52(3):551–6. PMID: 8447321","Мазунин И.О., Володько Н.В., Стариковская Е.Б., Сукерник Р.И. Митохондриальный геном и митохондриальные заболевания человека. Молекулярная биология. 2010;44(5):755–72.","Celentano V., Esposito E., Perrotta S., Giglio M.C., Tarquini R., Luglio G., et al. Madelung disease: report of a case and review of the literature. Acta Chir Belg. 2014;114(6):417–20. PMID: 26021689","Lemaitre M., Chevalier B., Jannin A., Bourry J., Espiard S., Vantyghem M.C. Multiple symmetric and multiple familial lipomatosis. Presse Med. 2021;50(3):104077. DOI: 10.1016/j.lpm.2021.104077","Вецмадян Е.А., Труфанов Г.Е., Рязанов В.В., Мостовая О.Т., Новиков К.В., Карайванов Н.С. Ультразвуковая диагностика липом мягких тканей с использованием методик цветного допплеровского картирования и эластографии. Вестник Российской Военно-медицинской академии. 2012;2(38):43–50.","Богов А.А., Андреев П.С., Филиппов В.Л., Топыркин В.Г. Оперативное лечение болезни Маделунга. Практическая медицина. 2018;16(7-1):90–3.","Уракова Е.В., Нестеров О.В., Ильина Р.Ю., Лексин Р.В. Хирургическая тактика при рецидивирующем липоматозе (болезни Маделунга). Клинический случай. Практическая медицина. 2022;20(6):131–3.","Егай А.А., Тентимишев А.Э., Норматов Р.М., Тян А.С. Хирургическое лечение множественного симметричного липоматоза (болезнь Маделунга), осложненного сдавлением яремных вен с обеих сторон. Преимущества липэктомии перед липосакцией. Научное обозрение. Медицинские науки. 2022;1:5– 10. DOI: 10.17513/srms.1225","Тимербулатов М.В., Шорнина А.С., Лихтер Р.А., Каипов А.Э. Оценка липосакции в структуре абдоминопластики и сочетанной герниоабдоминопластики. Креативная хирургия и онкология. 2023;13(4):278–83. DOI: 10.24060/2076-3093-2023-13-4-278-283","Dang Y., Du X., Ou X., Zheng Q., Xie F. Advances in diagnosis and treatment of Madelung’s deformity. Am J Transl Res. 2023;15(7):4416–24.","Leti Acciaro A, Garagnani L, Lando M, Lana D, Sartini S, Adani R. Modified dome osteotomy and anterior locking plate fixation for distal radius variant of Madelung deformity: a retrospective study. J Plast Surg Hand Surg. 2022;56(2):121–6. DOI: 10.1080/2000656X.2021.1934845"],"dc.citation.ru":["Liu Q., Lyu H., Xu B., Lee J.H. Madelung disease epidemiology and clinical characteristics: a systemic review. Aesthetic Plast Surg. 2021;45(3):977–86. DOI: 10.1007/s00266-020-02083-5","Sia K.J., Tang I.P., Tan T.Y. Multiple symmetrical lipomatosis: case report and literature review. J Laryngol Otol. 2012;126(7):756–8. DOI: 10.1017/S0022215112000709","Kratz C., Lenard H.G., Ruzicka T., Gärtner J. Multiple symmetric lipomatosis: an unusual cause of childhood obesity and mental retardation. Eur J Paediatr Neurol. 2000;4(2):63–7. DOI: 10.1053/ejpn.2000.0264","Nounla J., Rolle U., Gräfe G., Kräling K. Benign symmetric lipomatosis with myelomeningocele in an adolescent: An uncommon association-case report. J Pediatr Surg. 2001;36(7):E13. DOI: 10.1053/jpsu.2001.24776","Madelung O.W. Über den Fetthals (diffuses Lipom des Halses). Arch Klin Chir. 1888;37:106-30.","Lanois P.E., Bensaude R. De ladeno-lipomatosesymetrique. Bull Mem Soc Med Hosp. 1898;1:298.","El Ouahabi H., Doubi S., Lahlou K., Boujraf S., Ajdi F. Launois-bensaude syndrome: A benign symmetric lipomatosis without alcohol association. Ann Afr Med. 2017;16(1):33–4. DOI: 10.4103/1596-3519.202082","Chen C.Y., Fang Q.Q., Wang X.F., Zhang M.X., Zhao W.Y., Shi B.H., et al. Madelung’s disease: lipectomy or liposuction? Biomed Res Int. 2018;3975974. DOI: 10.1155/2018/3975974","Coker J.E., Bryan J.A. Endocrine and metabolic disorders: Causes and pathogenesis of obesity. J. Fam. Pract. 2008;4:21–6.","González-García R., Rodríguez-Campo F.J., Sastre-Pérez J., Muñoz-Guerra M.F. Benign symmetric lipomatosis (Madelung’s disease): case reports and current management. Aesthetic Plast Surg. 2004;28(2):108– 12; discussion 113. DOI: 10.1007/s00266-004-3123-5","Holme E., Larsson N.G., Oldfors A., Tulinius M., Sahlin P., Stenman G. Multiple symmetric lipomas with high levels of mtDNA with the tRNA(Lys) A-->G(8344) mutation as the only manifestation of disease in a carrier of myoclonus epilepsy and ragged-red fibers (MERRF) syndrome. Am J Hum Genet. 1993r;52(3):551–6. PMID: 8447321","Мазунин И.О., Володько Н.В., Стариковская Е.Б., Сукерник Р.И. Митохондриальный геном и митохондриальные заболевания человека. Молекулярная биология. 2010;44(5):755–72.","Celentano V., Esposito E., Perrotta S., Giglio M.C., Tarquini R., Luglio G., et al. Madelung disease: report of a case and review of the literature. Acta Chir Belg. 2014;114(6):417–20. PMID: 26021689","Lemaitre M., Chevalier B., Jannin A., Bourry J., Espiard S., Vantyghem M.C. Multiple symmetric and multiple familial lipomatosis. Presse Med. 2021;50(3):104077. DOI: 10.1016/j.lpm.2021.104077","Вецмадян Е.А., Труфанов Г.Е., Рязанов В.В., Мостовая О.Т., Новиков К.В., Карайванов Н.С. Ультразвуковая диагностика липом мягких тканей с использованием методик цветного допплеровского картирования и эластографии. Вестник Российской Военно-медицинской академии. 2012;2(38):43–50.","Богов А.А., Андреев П.С., Филиппов В.Л., Топыркин В.Г. Оперативное лечение болезни Маделунга. Практическая медицина. 2018;16(7-1):90–3.","Уракова Е.В., Нестеров О.В., Ильина Р.Ю., Лексин Р.В. Хирургическая тактика при рецидивирующем липоматозе (болезни Маделунга). Клинический случай. Практическая медицина. 2022;20(6):131–3.","Егай А.А., Тентимишев А.Э., Норматов Р.М., Тян А.С. Хирургическое лечение множественного симметричного липоматоза (болезнь Маделунга), осложненного сдавлением яремных вен с обеих сторон. Преимущества липэктомии перед липосакцией. Научное обозрение. Медицинские науки. 2022;1:5– 10. DOI: 10.17513/srms.1225","Тимербулатов М.В., Шорнина А.С., Лихтер Р.А., Каипов А.Э. Оценка липосакции в структуре абдоминопластики и сочетанной герниоабдоминопластики. Креативная хирургия и онкология. 2023;13(4):278–83. DOI: 10.24060/2076-3093-2023-13-4-278-283","Dang Y., Du X., Ou X., Zheng Q., Xie F. Advances in diagnosis and treatment of Madelung’s deformity. Am J Transl Res. 2023;15(7):4416–24.","Leti Acciaro A, Garagnani L, Lando M, Lana D, Sartini S, Adani R. Modified dome osteotomy and anterior locking plate fixation for distal radius variant of Madelung deformity: a retrospective study. J Plast Surg Hand Surg. 2022;56(2):121–6. DOI: 10.1080/2000656X.2021.1934845"],"dc.citation.en":["Liu Q., Lyu H., Xu B., Lee J.H. Madelung disease epidemiology and clinical characteristics: a systemic review. Aesthetic Plast Surg. 2021;45(3):977–86. DOI: 10.1007/s00266-020-02083-5","Sia K.J., Tang I.P., Tan T.Y. Multiple symmetrical lipomatosis: case report and literature review. J Laryngol Otol. 2012;126(7):756–8. DOI: 10.1017/S0022215112000709","Kratz C., Lenard H.G., Ruzicka T., Gärtner J. Multiple symmetric lipomatosis: an unusual cause of childhood obesity and mental retardation. Eur J Paediatr Neurol. 2000;4(2):63–7. DOI: 10.1053/ejpn.2000.0264","Nounla J., Rolle U., Gräfe G., Kräling K. Benign symmetric lipomatosis with myelomeningocele in an adolescent: An uncommon association-case report. J Pediatr Surg. 2001;36(7):E13. 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DOI: 10.1007/s00266-004-3123-5","Holme E., Larsson N.G., Oldfors A., Tulinius M., Sahlin P., Stenman G. Multiple symmetric lipomas with high levels of mtDNA with the tRNA(Lys) A-->G(8344) mutation as the only manifestation of disease in a carrier of myoclonus epilepsy and ragged-red fibers (MERRF) syndrome. Am J Hum Genet. 1993r;52(3):551–6. PMID: 8447321","Мазунин И.О., Володько Н.В., Стариковская Е.Б., Сукерник Р.И. Митохондриальный геном и митохондриальные заболевания человека. Молекулярная биология. 2010;44(5):755–72.","Celentano V., Esposito E., Perrotta S., Giglio M.C., Tarquini R., Luglio G., et al. Madelung disease: report of a case and review of the literature. Acta Chir Belg. 2014;114(6):417–20. PMID: 26021689","Lemaitre M., Chevalier B., Jannin A., Bourry J., Espiard S., Vantyghem M.C. Multiple symmetric and multiple familial lipomatosis. Presse Med. 2021;50(3):104077. DOI: 10.1016/j.lpm.2021.104077","Вецмадян Е.А., Труфанов Г.Е., Рязанов В.В., Мостовая О.Т., Новиков К.В., Карайванов Н.С. Ультразвуковая диагностика липом мягких тканей с использованием методик цветного допплеровского картирования и эластографии. Вестник Российской Военно-медицинской академии. 2012;2(38):43–50.","Богов А.А., Андреев П.С., Филиппов В.Л., Топыркин В.Г. Оперативное лечение болезни Маделунга. Практическая медицина. 2018;16(7-1):90–3.","Уракова Е.В., Нестеров О.В., Ильина Р.Ю., Лексин Р.В. Хирургическая тактика при рецидивирующем липоматозе (болезни Маделунга). Клинический случай. Практическая медицина. 2022;20(6):131–3.","Егай А.А., Тентимишев А.Э., Норматов Р.М., Тян А.С. Хирургическое лечение множественного симметричного липоматоза (болезнь Маделунга), осложненного сдавлением яремных вен с обеих сторон. Преимущества липэктомии перед липосакцией. Научное обозрение. Медицинские науки. 2022;1:5– 10. 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Larisa","Kzhyshkowska, Julia"],"author_keyword":["Larionova, Irina","Iamshchikov, Pavel","Kazakova, Anna","Rakina, Militsa","Menyalo, Maxim","Enikeeva, Kadriia","Rafikova, Guzel","Sharifyanova, Yuliya","Pavlov, Valentin","Villert, Alisa","Kolomiets, Larisa","Kzhyshkowska, Julia"],"author_ac":["larionova, irina\n|||\nLarionova, Irina","iamshchikov, pavel\n|||\nIamshchikov, Pavel","kazakova, anna\n|||\nKazakova, Anna","rakina, militsa\n|||\nRakina, Militsa","menyalo, maxim\n|||\nMenyalo, Maxim","enikeeva, kadriia\n|||\nEnikeeva, Kadriia","rafikova, guzel\n|||\nRafikova, Guzel","sharifyanova, yuliya\n|||\nSharifyanova, Yuliya","pavlov, valentin\n|||\nPavlov, Valentin","villert, alisa\n|||\nVillert, Alisa","kolomiets, larisa\n|||\nKolomiets, Larisa","kzhyshkowska, julia\n|||\nKzhyshkowska, Julia"],"author_filter":["larionova, irina\n|||\nLarionova, Irina","iamshchikov, pavel\n|||\nIamshchikov, Pavel","kazakova, anna\n|||\nKazakova, Anna","rakina, militsa\n|||\nRakina, Militsa","menyalo, maxim\n|||\nMenyalo, Maxim","enikeeva, kadriia\n|||\nEnikeeva, Kadriia","rafikova, guzel\n|||\nRafikova, Guzel","sharifyanova, yuliya\n|||\nSharifyanova, Yuliya","pavlov, valentin\n|||\nPavlov, Valentin","villert, alisa\n|||\nVillert, Alisa","kolomiets, larisa\n|||\nKolomiets, Larisa","kzhyshkowska, julia\n|||\nKzhyshkowska, Julia"],"dc.contributor.author_hl":["Larionova, Irina","Iamshchikov, Pavel","Kazakova, Anna","Rakina, Militsa","Menyalo, Maxim","Enikeeva, Kadriia","Rafikova, Guzel","Sharifyanova, Yuliya","Pavlov, Valentin","Villert, Alisa","Kolomiets, Larisa","Kzhyshkowska, Julia"],"dc.contributor.author_mlt":["Larionova, Irina","Iamshchikov, Pavel","Kazakova, Anna","Rakina, Militsa","Menyalo, Maxim","Enikeeva, Kadriia","Rafikova, Guzel","Sharifyanova, Yuliya","Pavlov, Valentin","Villert, Alisa","Kolomiets, Larisa","Kzhyshkowska, Julia"],"dc.contributor.author":["Larionova, Irina","Iamshchikov, Pavel","Kazakova, Anna","Rakina, Militsa","Menyalo, Maxim","Enikeeva, Kadriia","Rafikova, Guzel","Sharifyanova, Yuliya","Pavlov, Valentin","Villert, Alisa","Kolomiets, Larisa","Kzhyshkowska, Julia"],"dc.contributor.author_stored":["Larionova, Irina\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Iamshchikov, Pavel\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Kazakova, Anna\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Rakina, Militsa\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Menyalo, Maxim\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Enikeeva, Kadriia\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Rafikova, Guzel\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Sharifyanova, Yuliya\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Pavlov, Valentin\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Villert, Alisa\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Kolomiets, Larisa\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Kzhyshkowska, Julia\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen"],"dc.contributor.author.en":["Larionova, Irina","Iamshchikov, Pavel","Kazakova, Anna","Rakina, Militsa","Menyalo, Maxim","Enikeeva, Kadriia","Rafikova, Guzel","Sharifyanova, Yuliya","Pavlov, Valentin","Villert, Alisa","Kolomiets, Larisa","Kzhyshkowska, Julia"],"dc.date.accessioned_dt":"2025-05-07T11:01:55Z","dc.date.accessioned":["2025-05-07T11:01:55Z"],"dc.date.available":["2025-05-07T11:01:55Z"],"dateIssued":["2025-01-01"],"dateIssued_keyword":["2025-01-01","2025"],"dateIssued_ac":["2025-01-01\n|||\n2025-01-01","2025"],"dateIssued.year":[2025],"dateIssued.year_sort":"2025","dc.date.issued_dt":"2025-01-01T00:00:00Z","dc.date.issued":["2025-01-01"],"dc.date.issued_stored":["2025-01-01\n|||\nnull\n|||\nnull\n|||\nnull\n|||\n"],"dc.description.abstract_hl":["Ovarian cancer (OC) is the most lethal gynecologic malignancy worldwide. The major clinical challenge includes the asymptomatic state of the disease, making diagnosis possible only at advanced stages. Another OC complication is the high relapse rate and poor prognosis following the standard first-line treatment with platinum-based chemotherapy. At present, numerous clinical trials are being conducted focusing on immunotherapy in OC; nevertheless, there are still no FDA-approved indications. Personalized decision regarding the immunotherapy, including immune checkpoint blockade and immune cell–based immunotherapies, can depend on the effective antigen presentation required for the cytotoxic immune response. The major aim of our study was to uncover tumor-specific transcriptional and epigenetic changes in peripheral blood monocytes in patients with high-grade serous ovarian cancer (HGSOC). Another key point was to elucidate how chemotherapy can reprogram monocytes and how that relates to changes in other immune subpopulations in the blood. To this end, we performed single-cell RNA sequencing of peripheral blood mononuclear cells (PBMCs) from patients with HGSOC who underwent neoadjuvant chemotherapeutic treatment (NACT) and in treatment-naïve patients. Monocyte cluster was significantly affected by tumor-derived factors as well as by chemotherapeutic treatment. Bioinformatical analysis revealed three distinct monocyte subpopulations within PBMCs based on feature gene expression – CD14.Mn.S100A8.9hi, CD14.Mn.MHC2hi and CD16.Mn subsets. The intriguing result was that NACT induced antigen presentation in monocytes by the transcriptional upregulation of MHC class II molecules, but not by epigenetic changes. Increased MHC class II gene expression was a feature observed across all three monocyte subpopulations after chemotherapy. Our data also demonstrated that chemotherapy inhibited interferon-dependent signaling pathways, but activated some TGFb-related genes. Our results can enable personalized decision regarding the necessity to systemically re-educate immune cells to prime ovarian cancer to respond to anti-cancer therapy or to improve personalized prescription of existing immunotherapy in either combination with chemotherapy or a monotherapy regimen. Copyright © 2024 Larionova, Iamshchikov, Kazakova, Rakina, Menyalo, Enikeeva, Rafikova, Sharifyanova, Pavlov, Villert, Kolomiets and Kzhyshkowska."],"dc.description.abstract":["Ovarian cancer (OC) is the most lethal gynecologic malignancy worldwide. The major clinical challenge includes the asymptomatic state of the disease, making diagnosis possible only at advanced stages. Another OC complication is the high relapse rate and poor prognosis following the standard first-line treatment with platinum-based chemotherapy. At present, numerous clinical trials are being conducted focusing on immunotherapy in OC; nevertheless, there are still no FDA-approved indications. Personalized decision regarding the immunotherapy, including immune checkpoint blockade and immune cell–based immunotherapies, can depend on the effective antigen presentation required for the cytotoxic immune response. The major aim of our study was to uncover tumor-specific transcriptional and epigenetic changes in peripheral blood monocytes in patients with high-grade serous ovarian cancer (HGSOC). Another key point was to elucidate how chemotherapy can reprogram monocytes and how that relates to changes in other immune subpopulations in the blood. To this end, we performed single-cell RNA sequencing of peripheral blood mononuclear cells (PBMCs) from patients with HGSOC who underwent neoadjuvant chemotherapeutic treatment (NACT) and in treatment-naïve patients. Monocyte cluster was significantly affected by tumor-derived factors as well as by chemotherapeutic treatment. Bioinformatical analysis revealed three distinct monocyte subpopulations within PBMCs based on feature gene expression – CD14.Mn.S100A8.9hi, CD14.Mn.MHC2hi and CD16.Mn subsets. The intriguing result was that NACT induced antigen presentation in monocytes by the transcriptional upregulation of MHC class II molecules, but not by epigenetic changes. Increased MHC class II gene expression was a feature observed across all three monocyte subpopulations after chemotherapy. Our data also demonstrated that chemotherapy inhibited interferon-dependent signaling pathways, but activated some TGFb-related genes. Our results can enable personalized decision regarding the necessity to systemically re-educate immune cells to prime ovarian cancer to respond to anti-cancer therapy or to improve personalized prescription of existing immunotherapy in either combination with chemotherapy or a monotherapy regimen. Copyright © 2024 Larionova, Iamshchikov, Kazakova, Rakina, Menyalo, Enikeeva, Rafikova, Sharifyanova, Pavlov, Villert, Kolomiets and Kzhyshkowska."],"dc.description.abstract.en":["Ovarian cancer (OC) is the most lethal gynecologic malignancy worldwide. The major clinical challenge includes the asymptomatic state of the disease, making diagnosis possible only at advanced stages. Another OC complication is the high relapse rate and poor prognosis following the standard first-line treatment with platinum-based chemotherapy. At present, numerous clinical trials are being conducted focusing on immunotherapy in OC; nevertheless, there are still no FDA-approved indications. Personalized decision regarding the immunotherapy, including immune checkpoint blockade and immune cell–based immunotherapies, can depend on the effective antigen presentation required for the cytotoxic immune response. The major aim of our study was to uncover tumor-specific transcriptional and epigenetic changes in peripheral blood monocytes in patients with high-grade serous ovarian cancer (HGSOC). Another key point was to elucidate how chemotherapy can reprogram monocytes and how that relates to changes in other immune subpopulations in the blood. To this end, we performed single-cell RNA sequencing of peripheral blood mononuclear cells (PBMCs) from patients with HGSOC who underwent neoadjuvant chemotherapeutic treatment (NACT) and in treatment-naïve patients. Monocyte cluster was significantly affected by tumor-derived factors as well as by chemotherapeutic treatment. Bioinformatical analysis revealed three distinct monocyte subpopulations within PBMCs based on feature gene expression – CD14.Mn.S100A8.9hi, CD14.Mn.MHC2hi and CD16.Mn subsets. The intriguing result was that NACT induced antigen presentation in monocytes by the transcriptional upregulation of MHC class II molecules, but not by epigenetic changes. Increased MHC class II gene expression was a feature observed across all three monocyte subpopulations after chemotherapy. Our data also demonstrated that chemotherapy inhibited interferon-dependent signaling pathways, but activated some TGFb-related genes. Our results can enable personalized decision regarding the necessity to systemically re-educate immune cells to prime ovarian cancer to respond to anti-cancer therapy or to improve personalized prescription of existing immunotherapy in either combination with chemotherapy or a monotherapy regimen. Copyright © 2024 Larionova, Iamshchikov, Kazakova, Rakina, Menyalo, Enikeeva, Rafikova, Sharifyanova, Pavlov, Villert, Kolomiets and Kzhyshkowska."],"dc.doi":["10.3389/fimmu.2024.1414716"],"dc.doi.en":["10.3389/fimmu.2024.1414716"],"dc.identifier.issn":["1664-3224"],"dc.identifier.uri":["http://hdl.handle.net/123456789/8832"],"dc.language.iso":["en"],"dc.language.iso.en":["en"],"dc.publisher":["Frontiers Media SA"],"dc.publisher.en":["Frontiers Media SA"],"dc.relation.ispartofseries":["Frontiers in Immunology;v. 15"],"dc.relation.ispartofseries.en":["Frontiers in Immunology;v. 15"],"subject":["antigen presentation","chemotherapy","methylation","monocyte","ovarian cancer","single cell sequencing","transcriptome","Scopus"],"subject_keyword":["antigen presentation","antigen presentation","chemotherapy","chemotherapy","methylation","methylation","monocyte","monocyte","ovarian cancer","ovarian cancer","single cell sequencing","single cell sequencing","transcriptome","transcriptome","Scopus","Scopus"],"subject_ac":["antigen presentation\n|||\nantigen presentation","chemotherapy\n|||\nchemotherapy","methylation\n|||\nmethylation","monocyte\n|||\nmonocyte","ovarian cancer\n|||\novarian cancer","single cell sequencing\n|||\nsingle cell sequencing","transcriptome\n|||\ntranscriptome","scopus\n|||\nScopus"],"subject_tax_0_filter":["antigen presentation\n|||\nantigen presentation","chemotherapy\n|||\nchemotherapy","methylation\n|||\nmethylation","monocyte\n|||\nmonocyte","ovarian cancer\n|||\novarian cancer","single cell sequencing\n|||\nsingle cell sequencing","transcriptome\n|||\ntranscriptome","scopus\n|||\nScopus"],"subject_filter":["antigen presentation\n|||\nantigen presentation","chemotherapy\n|||\nchemotherapy","methylation\n|||\nmethylation","monocyte\n|||\nmonocyte","ovarian cancer\n|||\novarian cancer","single cell sequencing\n|||\nsingle cell sequencing","transcriptome\n|||\ntranscriptome","scopus\n|||\nScopus"],"dc.subject_mlt":["antigen presentation","chemotherapy","methylation","monocyte","ovarian cancer","single cell sequencing","transcriptome","Scopus"],"dc.subject":["antigen presentation","chemotherapy","methylation","monocyte","ovarian cancer","single cell sequencing","transcriptome","Scopus"],"dc.subject.en":["antigen presentation","chemotherapy","methylation","monocyte","ovarian cancer","single cell sequencing","transcriptome","Scopus"],"title":["Platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma"],"title_keyword":["Platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma"],"title_ac":["platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma\n|||\nPlatinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma"],"dc.title_sort":"Platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma","dc.title_hl":["Platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma"],"dc.title_mlt":["Platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma"],"dc.title":["Platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma"],"dc.title_stored":["Platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen"],"dc.title.en":["Platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma"],"dc.title.alternative":["Platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma"],"dc.title.alternative.en":["Platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma"],"dc.type":["Article"],"dc.type.en":["Article"],"publication_grp":["123456789/8832"],"bi_2_dis_filter":["kazakova, anna\n|||\nKazakova, Anna","rakina, militsa\n|||\nRakina, Militsa","enikeeva, kadriia\n|||\nEnikeeva, Kadriia","larionova, irina\n|||\nLarionova, Irina","rafikova, guzel\n|||\nRafikova, Guzel","kzhyshkowska, julia\n|||\nKzhyshkowska, Julia","kolomiets, larisa\n|||\nKolomiets, Larisa","menyalo, maxim\n|||\nMenyalo, Maxim","sharifyanova, yuliya\n|||\nSharifyanova, Yuliya","pavlov, valentin\n|||\nPavlov, Valentin","villert, alisa\n|||\nVillert, Alisa","iamshchikov, pavel\n|||\nIamshchikov, Pavel"],"bi_2_dis_partial":["Menyalo, Maxim","Kolomiets, Larisa","Kzhyshkowska, Julia","Enikeeva, Kadriia","Rafikova, Guzel","Rakina, Militsa","Sharifyanova, Yuliya","Pavlov, Valentin","Larionova, Irina","Iamshchikov, Pavel","Kazakova, Anna","Villert, Alisa"],"bi_2_dis_value_filter":["Menyalo, Maxim","Kolomiets, Larisa","Kzhyshkowska, Julia","Enikeeva, Kadriia","Rafikova, Guzel","Rakina, Militsa","Sharifyanova, Yuliya","Pavlov, Valentin","Larionova, Irina","Iamshchikov, Pavel","Kazakova, Anna","Villert, Alisa"],"bi_4_dis_filter":["ovarian cancer\n|||\novarian cancer","transcriptome\n|||\ntranscriptome","chemotherapy\n|||\nchemotherapy","antigen presentation\n|||\nantigen presentation","methylation\n|||\nmethylation","single cell sequencing\n|||\nsingle cell sequencing","scopus\n|||\nScopus","monocyte\n|||\nmonocyte"],"bi_4_dis_partial":["antigen presentation","ovarian cancer","methylation","transcriptome","Scopus","monocyte","single cell sequencing","chemotherapy"],"bi_4_dis_value_filter":["antigen presentation","ovarian cancer","methylation","transcriptome","Scopus","monocyte","single cell sequencing","chemotherapy"],"bi_sort_1_sort":"platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma","bi_sort_2_sort":"2025","bi_sort_3_sort":"2025-05-07T11:01:55Z","read":["g0"],"_version_":1831459417815515136},{"SolrIndexer.lastIndexed":"2025-04-28T12:28:38.28Z","search.uniqueid":"2-7899","search.resourcetype":2,"search.resourceid":7899,"handle":"123456789/8788","location":["m229","l684"],"location.comm":["229"],"location.coll":["684"],"withdrawn":"false","discoverable":"true","dc.abstract":["Introduction. Currently, the growth of the overweight and obese population is increasing every year, which confirms that the problem in question has been assigned the status of a non-infectious epidemic of the 21st century. At the same time, the prevalence of cognitive impairment is extremely high among the global population. According to the World Health Organization (WHO), there are suggestions that due to the increased life expectancy, this figure may have grown threefold by 2050. The aim of this study is to analyze data published in modern literature, which links obesity with cognitive impairment. Materials and Methods. The review includes data from foreign and domestic studies published in electronic bibliographic databases, such as Pubmed, Cochrane Library, Web of Science, Google Scholar, and Cyberleninka, over the past 10 years. Publications were analyzed that provide information on risk factors and pathogenetic aspects of obesity and cognitive impairment. Results and Discussion. Relevant information was collected regarding the comorbidity of cognitive changes in obesity. We have systematized the data related to the analysis of possible pathophysiological mechanisms justifying this relationship and analyzed the gender- and age-related characteristics of the nature of cognitive impairment. Conclusions. Various studies have shown that obesity is associated with a high prevalence of developing cognitive impairment. In the development of cognitive impairment in obese patients, a combination of factors is essential, namely, hyperleptinemia, leptin resistance, hyperinsulinemia and impaired carbohydrate tolerance, increased activity of pro-inflammatory markers, endothelial dysfunction and hypercholesterolemia, as well as polymorphic gene variants and the endocannabinoid system. According to the research findings, changes in overweight and obesity mainly occur in the form of mild cognitive decline affecting memory, attention, language, praxis, and learning ability. Age-related differences have been identified regarding cognitive changes in obesity: In children and adolescents, these changes are more often associated with impaired memory function and concentration, while in middle-aged people – with general cognitive decline. © 2025 LLC IMC Modern Clinical Medicine. All rights reserved."],"dc.abstract.en":["Introduction. Currently, the growth of the overweight and obese population is increasing every year, which confirms that the problem in question has been assigned the status of a non-infectious epidemic of the 21st century. At the same time, the prevalence of cognitive impairment is extremely high among the global population. According to the World Health Organization (WHO), there are suggestions that due to the increased life expectancy, this figure may have grown threefold by 2050. The aim of this study is to analyze data published in modern literature, which links obesity with cognitive impairment. Materials and Methods. The review includes data from foreign and domestic studies published in electronic bibliographic databases, such as Pubmed, Cochrane Library, Web of Science, Google Scholar, and Cyberleninka, over the past 10 years. Publications were analyzed that provide information on risk factors and pathogenetic aspects of obesity and cognitive impairment. Results and Discussion. Relevant information was collected regarding the comorbidity of cognitive changes in obesity. We have systematized the data related to the analysis of possible pathophysiological mechanisms justifying this relationship and analyzed the gender- and age-related characteristics of the nature of cognitive impairment. Conclusions. Various studies have shown that obesity is associated with a high prevalence of developing cognitive impairment. In the development of cognitive impairment in obese patients, a combination of factors is essential, namely, hyperleptinemia, leptin resistance, hyperinsulinemia and impaired carbohydrate tolerance, increased activity of pro-inflammatory markers, endothelial dysfunction and hypercholesterolemia, as well as polymorphic gene variants and the endocannabinoid system. According to the research findings, changes in overweight and obesity mainly occur in the form of mild cognitive decline affecting memory, attention, language, praxis, and learning ability. Age-related differences have been identified regarding cognitive changes in obesity: In children and adolescents, these changes are more often associated with impaired memory function and concentration, while in middle-aged people – with general cognitive decline. © 2025 LLC IMC Modern Clinical Medicine. All rights reserved."],"author":["Mutalova, Elvira G.","Nafikova, Azalia I.","Nigmatullina, Albina E.","Galyautdinova, Velena R.","Kamaltdinova, Gulnara J.","Asadullina, Gulnara V.","Samigullina, Liana I.","Rustyamova, Zulfiya Ya.","Sadikova, Regina I.","Frid, Svetlana A.","Musina, Flarisa S.","Zhumaniyazova, Altinai A.","Муталова, Э.Г.","Нафикова, А.И.","Нигматуллина, А.Э.","Галяутдинова, В.Р.","Камалтдинова, Г.Я.","Асадуллина, Г.В.","Самигуллина, Л.И.","Рустямова, З.Я.","Садикова, Р.И.","Фрид, С.А.","Мусина, Ф.С.","Жуманиязова, А.А."],"author_keyword":["Mutalova, Elvira G.","Nafikova, Azalia I.","Nigmatullina, Albina E.","Galyautdinova, Velena R.","Kamaltdinova, Gulnara J.","Asadullina, Gulnara V.","Samigullina, Liana I.","Rustyamova, Zulfiya Ya.","Sadikova, Regina I.","Frid, Svetlana A.","Musina, Flarisa S.","Zhumaniyazova, Altinai A.","Муталова, Э.Г.","Нафикова, А.И.","Нигматуллина, А.Э.","Галяутдинова, В.Р.","Камалтдинова, Г.Я.","Асадуллина, Г.В.","Самигуллина, Л.И.","Рустямова, З.Я.","Садикова, Р.И.","Фрид, С.А.","Мусина, Ф.С.","Жуманиязова, А.А."],"author_ac":["mutalova, elvira g.\n|||\nMutalova, Elvira G.","nafikova, azalia i.\n|||\nNafikova, Azalia I.","nigmatullina, albina e.\n|||\nNigmatullina, Albina E.","galyautdinova, velena r.\n|||\nGalyautdinova, Velena R.","kamaltdinova, gulnara j.\n|||\nKamaltdinova, Gulnara J.","asadullina, gulnara v.\n|||\nAsadullina, Gulnara V.","samigullina, liana i.\n|||\nSamigullina, Liana I.","rustyamova, zulfiya ya.\n|||\nRustyamova, Zulfiya Ya.","sadikova, regina i.\n|||\nSadikova, Regina I.","frid, svetlana a.\n|||\nFrid, Svetlana A.","musina, flarisa s.\n|||\nMusina, Flarisa S.","zhumaniyazova, altinai a.\n|||\nZhumaniyazova, Altinai A.","муталова, э.г.\n|||\nМуталова, Э.Г.","нафикова, а.и.\n|||\nНафикова, А.И.","нигматуллина, а.э.\n|||\nНигматуллина, А.Э.","галяутдинова, в.р.\n|||\nГаляутдинова, В.Р.","камалтдинова, г.я.\n|||\nКамалтдинова, Г.Я.","асадуллина, г.в.\n|||\nАсадуллина, Г.В.","самигуллина, л.и.\n|||\nСамигуллина, Л.И.","рустямова, з.я.\n|||\nРустямова, З.Я.","садикова, р.и.\n|||\nСадикова, Р.И.","фрид, с.а.\n|||\nФрид, С.А.","мусина, ф.с.\n|||\nМусина, Ф.С.","жуманиязова, а.а.\n|||\nЖуманиязова, А.А."],"author_filter":["mutalova, elvira g.\n|||\nMutalova, Elvira G.","nafikova, azalia i.\n|||\nNafikova, Azalia I.","nigmatullina, albina e.\n|||\nNigmatullina, Albina E.","galyautdinova, velena r.\n|||\nGalyautdinova, Velena R.","kamaltdinova, gulnara j.\n|||\nKamaltdinova, Gulnara J.","asadullina, gulnara v.\n|||\nAsadullina, Gulnara V.","samigullina, liana i.\n|||\nSamigullina, Liana I.","rustyamova, zulfiya ya.\n|||\nRustyamova, Zulfiya Ya.","sadikova, regina i.\n|||\nSadikova, Regina I.","frid, svetlana a.\n|||\nFrid, Svetlana A.","musina, flarisa s.\n|||\nMusina, Flarisa S.","zhumaniyazova, altinai a.\n|||\nZhumaniyazova, Altinai A.","муталова, э.г.\n|||\nМуталова, Э.Г.","нафикова, а.и.\n|||\nНафикова, А.И.","нигматуллина, а.э.\n|||\nНигматуллина, А.Э.","галяутдинова, в.р.\n|||\nГаляутдинова, В.Р.","камалтдинова, г.я.\n|||\nКамалтдинова, Г.Я.","асадуллина, г.в.\n|||\nАсадуллина, Г.В.","самигуллина, л.и.\n|||\nСамигуллина, Л.И.","рустямова, з.я.\n|||\nРустямова, З.Я.","садикова, р.и.\n|||\nСадикова, Р.И.","фрид, с.а.\n|||\nФрид, С.А.","мусина, ф.с.\n|||\nМусина, Ф.С.","жуманиязова, а.а.\n|||\nЖуманиязова, А.А."],"dc.contributor.author_hl":["Mutalova, Elvira G.","Nafikova, Azalia I.","Nigmatullina, Albina E.","Galyautdinova, Velena R.","Kamaltdinova, Gulnara J.","Asadullina, Gulnara V.","Samigullina, Liana I.","Rustyamova, Zulfiya Ya.","Sadikova, Regina I.","Frid, Svetlana A.","Musina, Flarisa S.","Zhumaniyazova, Altinai A.","Муталова, Э.Г.","Нафикова, А.И.","Нигматуллина, А.Э.","Галяутдинова, В.Р.","Камалтдинова, Г.Я.","Асадуллина, Г.В.","Самигуллина, Л.И.","Рустямова, З.Я.","Садикова, Р.И.","Фрид, С.А.","Мусина, Ф.С.","Жуманиязова, А.А."],"dc.contributor.author_mlt":["Mutalova, Elvira G.","Nafikova, Azalia I.","Nigmatullina, Albina E.","Galyautdinova, Velena R.","Kamaltdinova, Gulnara J.","Asadullina, Gulnara V.","Samigullina, Liana I.","Rustyamova, Zulfiya Ya.","Sadikova, Regina I.","Frid, Svetlana A.","Musina, Flarisa S.","Zhumaniyazova, Altinai A.","Муталова, Э.Г.","Нафикова, А.И.","Нигматуллина, А.Э.","Галяутдинова, В.Р.","Камалтдинова, Г.Я.","Асадуллина, Г.В.","Самигуллина, Л.И.","Рустямова, З.Я.","Садикова, Р.И.","Фрид, С.А.","Мусина, Ф.С.","Жуманиязова, А.А."],"dc.contributor.author":["Mutalova, Elvira G.","Nafikova, Azalia I.","Nigmatullina, Albina E.","Galyautdinova, Velena R.","Kamaltdinova, Gulnara J.","Asadullina, Gulnara V.","Samigullina, Liana I.","Rustyamova, Zulfiya Ya.","Sadikova, Regina I.","Frid, Svetlana A.","Musina, Flarisa S.","Zhumaniyazova, Altinai A.","Муталова, Э.Г.","Нафикова, А.И.","Нигматуллина, А.Э.","Галяутдинова, В.Р.","Камалтдинова, Г.Я.","Асадуллина, Г.В.","Самигуллина, Л.И.","Рустямова, З.Я.","Садикова, Р.И.","Фрид, С.А.","Мусина, Ф.С.","Жуманиязова, А.А."],"dc.contributor.author_stored":["Mutalova, Elvira G.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Nafikova, Azalia I.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Nigmatullina, Albina E.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Galyautdinova, Velena R.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Kamaltdinova, Gulnara J.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Asadullina, Gulnara V.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Samigullina, Liana I.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Rustyamova, Zulfiya Ya.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Sadikova, Regina I.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Frid, Svetlana A.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Musina, Flarisa S.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Zhumaniyazova, Altinai A.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Муталова, Э.Г.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nru_RU","Нафикова, А.И.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nru_RU","Нигматуллина, А.Э.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nru_RU","Галяутдинова, В.Р.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nru_RU","Камалтдинова, Г.Я.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nru_RU","Асадуллина, Г.В.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nru_RU","Самигуллина, Л.И.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nru_RU","Рустямова, З.Я.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nru_RU","Садикова, Р.И.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nru_RU","Фрид, С.А.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nru_RU","Мусина, Ф.С.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nru_RU","Жуманиязова, А.А.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nru_RU"],"dc.contributor.author.en":["Mutalova, Elvira G.","Nafikova, Azalia I.","Nigmatullina, Albina E.","Galyautdinova, Velena R.","Kamaltdinova, Gulnara J.","Asadullina, Gulnara V.","Samigullina, Liana I.","Rustyamova, Zulfiya Ya.","Sadikova, Regina I.","Frid, Svetlana A.","Musina, Flarisa S.","Zhumaniyazova, Altinai A."],"dc.contributor.author.ru_RU":["Муталова, Э.Г.","Нафикова, А.И.","Нигматуллина, А.Э.","Галяутдинова, В.Р.","Камалтдинова, Г.Я.","Асадуллина, Г.В.","Самигуллина, Л.И.","Рустямова, З.Я.","Садикова, Р.И.","Фрид, С.А.","Мусина, Ф.С.","Жуманиязова, А.А."],"dc.date.accessioned_dt":"2025-04-28T12:26:20Z","dc.date.accessioned":["2025-04-28T12:26:20Z"],"dc.date.available":["2025-04-28T12:26:20Z"],"dateIssued":["2025-01-01"],"dateIssued_keyword":["2025-01-01","2025"],"dateIssued_ac":["2025-01-01\n|||\n2025-01-01","2025"],"dateIssued.year":[2025],"dateIssued.year_sort":"2025","dc.date.issued_dt":"2025-01-01T00:00:00Z","dc.date.issued":["2025-01-01"],"dc.date.issued_stored":["2025-01-01\n|||\nnull\n|||\nnull\n|||\nnull\n|||\n"],"dc.description.abstract_hl":["В настоящее время прирост населения с избыточной массой тела и ожирением увеличивается с каждым годом, что подтверждает присвоение рассматриваемой проблеме статус неинфекционной\nэпидемии 21 века. В то же время распространенность когнитивных нарушений среди населения планеты также\nчрезвычайно высока. По данным Всемирной организации здравоохранения (ВОЗ), высказываются предположения\nо том, что в результате увеличения продолжительности жизни населения к 2050 году этот показатель может вырасти в три раза. Цель исследования – провести анализ данных, опубликованных в современной литературе,\nсвязывающих ожирение с когнитивными нарушениями. Материал и методы. В обзор включены данные зарубежных и отечественных исследований, опубликованных в электронных библиографических базах данных Pubmed\nи Cochrane Library, Web of Science, Google Scholar и Cyberleninka за последние 10 лет. Проведен анализ работ,\nсодержащих информацию о факторах риска, патогенетических аспектах ожирения и когнитивных нарушений.\nРезультаты и их обсуждение. Собрана актуальная информация о коморбидности когнитивных изменений при\nожирении. Систематизированы данные, связанные с анализом возможных патофизиологические механизмов,\nоправдывающих эту связь, проанализированы гендерные и возрастные особенности характера когнитивных\nнарушений. Заключение. Различные исследования показали, что ожирение связано с большой распространенностью развития когнитивных нарушений. В развитии когнитивных нарушений у больных ожирением значимая\nроль принадлежит совокупности факторов – гиперлептинемии, лептинорезистентности, гиперинсулинемии и\nнарушению толерантности к углеводам, повышению активности провоспалительных маркеров, эндотелиальной\nдисфункции и гиперхолестеринемии, а также полиморфным вариантам генов и эндоканнабиноидной системе.\nСогласно результатам исследований, при избыточном весе и ожирении в основном встречаются изменения в виде\nлегкого когнитивного снижения, затрагивающего память, внимание, речь, праксис и способность к обучению.\nВыявлены возрастные различия в отношении когнитивных изменений при ожирении: у детей и подростков эти\nизменения чаще ассоциированы с нарушением функции памяти и концентрации внимания, у лиц среднего возраста – с общим когнитивным снижением."],"dc.description.abstract":["В настоящее время прирост населения с избыточной массой тела и ожирением увеличивается с каждым годом, что подтверждает присвоение рассматриваемой проблеме статус неинфекционной\nэпидемии 21 века. В то же время распространенность когнитивных нарушений среди населения планеты также\nчрезвычайно высока. По данным Всемирной организации здравоохранения (ВОЗ), высказываются предположения\nо том, что в результате увеличения продолжительности жизни населения к 2050 году этот показатель может вырасти в три раза. Цель исследования – провести анализ данных, опубликованных в современной литературе,\nсвязывающих ожирение с когнитивными нарушениями. Материал и методы. В обзор включены данные зарубежных и отечественных исследований, опубликованных в электронных библиографических базах данных Pubmed\nи Cochrane Library, Web of Science, Google Scholar и Cyberleninka за последние 10 лет. Проведен анализ работ,\nсодержащих информацию о факторах риска, патогенетических аспектах ожирения и когнитивных нарушений.\nРезультаты и их обсуждение. Собрана актуальная информация о коморбидности когнитивных изменений при\nожирении. Систематизированы данные, связанные с анализом возможных патофизиологические механизмов,\nоправдывающих эту связь, проанализированы гендерные и возрастные особенности характера когнитивных\nнарушений. Заключение. Различные исследования показали, что ожирение связано с большой распространенностью развития когнитивных нарушений. В развитии когнитивных нарушений у больных ожирением значимая\nроль принадлежит совокупности факторов – гиперлептинемии, лептинорезистентности, гиперинсулинемии и\nнарушению толерантности к углеводам, повышению активности провоспалительных маркеров, эндотелиальной\nдисфункции и гиперхолестеринемии, а также полиморфным вариантам генов и эндоканнабиноидной системе.\nСогласно результатам исследований, при избыточном весе и ожирении в основном встречаются изменения в виде\nлегкого когнитивного снижения, затрагивающего память, внимание, речь, праксис и способность к обучению.\nВыявлены возрастные различия в отношении когнитивных изменений при ожирении: у детей и подростков эти\nизменения чаще ассоциированы с нарушением функции памяти и концентрации внимания, у лиц среднего возраста – с общим когнитивным снижением."],"dc.description.abstract.ru_RU":["В настоящее время прирост населения с избыточной массой тела и ожирением увеличивается с каждым годом, что подтверждает присвоение рассматриваемой проблеме статус неинфекционной\nэпидемии 21 века. В то же время распространенность когнитивных нарушений среди населения планеты также\nчрезвычайно высока. По данным Всемирной организации здравоохранения (ВОЗ), высказываются предположения\nо том, что в результате увеличения продолжительности жизни населения к 2050 году этот показатель может вырасти в три раза. Цель исследования – провести анализ данных, опубликованных в современной литературе,\nсвязывающих ожирение с когнитивными нарушениями. Материал и методы. В обзор включены данные зарубежных и отечественных исследований, опубликованных в электронных библиографических базах данных Pubmed\nи Cochrane Library, Web of Science, Google Scholar и Cyberleninka за последние 10 лет. Проведен анализ работ,\nсодержащих информацию о факторах риска, патогенетических аспектах ожирения и когнитивных нарушений.\nРезультаты и их обсуждение. Собрана актуальная информация о коморбидности когнитивных изменений при\nожирении. Систематизированы данные, связанные с анализом возможных патофизиологические механизмов,\nоправдывающих эту связь, проанализированы гендерные и возрастные особенности характера когнитивных\nнарушений. Заключение. Различные исследования показали, что ожирение связано с большой распространенностью развития когнитивных нарушений. В развитии когнитивных нарушений у больных ожирением значимая\nроль принадлежит совокупности факторов – гиперлептинемии, лептинорезистентности, гиперинсулинемии и\nнарушению толерантности к углеводам, повышению активности провоспалительных маркеров, эндотелиальной\nдисфункции и гиперхолестеринемии, а также полиморфным вариантам генов и эндоканнабиноидной системе.\nСогласно результатам исследований, при избыточном весе и ожирении в основном встречаются изменения в виде\nлегкого когнитивного снижения, затрагивающего память, внимание, речь, праксис и способность к обучению.\nВыявлены возрастные различия в отношении когнитивных изменений при ожирении: у детей и подростков эти\nизменения чаще ассоциированы с нарушением функции памяти и концентрации внимания, у лиц среднего возраста – с общим когнитивным снижением."],"dc.doi":["10.20969/VSKM.2025.18(1).115-123"],"dc.doi.en":["10.20969/VSKM.2025.18(1).115-123"],"dc.identifier.issn":["2071-0240"],"dc.identifier.uri":["http://hdl.handle.net/123456789/8788"],"dc.publisher":["LLC \"IMC\" Modern Clinical Medicine"],"dc.publisher.en":["LLC \"IMC\" Modern Clinical Medicine"],"dc.relation.ispartofseries":["Vestnik Sovremennoi Klinicheskoi Mediciny;т. 18 № 1"],"dc.relation.ispartofseries.en":["Vestnik Sovremennoi Klinicheskoi Mediciny;т. 18 № 1"],"subject":["ожирение","когнитивная дисфункция","лептин","инсулинорезистентность","гипертриглицеридемия","воспаление","эндотелиальная дисфункция","метаболический синдром","cognitive dysfunction","endothelial dysfunction","hypertriglyceridemia","inflammation","insulin resistance","leptin","metabolic syndrome","obesity","Scopus"],"subject_keyword":["ожирение","ожирение","когнитивная дисфункция","когнитивная 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obesity","Взаимосвязь когнитивных нарушений и ожирения"],"title_ac":["relationship between cognitive impairment and obesity\n|||\nRelationship between cognitive impairment and obesity","взаимосвязь когнитивных нарушений и ожирения\n|||\nВзаимосвязь когнитивных нарушений и ожирения"],"dc.title_sort":"Relationship between cognitive impairment and obesity","dc.title_hl":["Relationship between cognitive impairment and obesity","Взаимосвязь когнитивных нарушений и ожирения"],"dc.title_mlt":["Relationship between cognitive impairment and obesity","Взаимосвязь когнитивных нарушений и ожирения"],"dc.title":["Relationship between cognitive impairment and obesity","Взаимосвязь когнитивных нарушений и ожирения"],"dc.title_stored":["Relationship between cognitive impairment and obesity\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Взаимосвязь когнитивных нарушений и ожирения\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nru_RU"],"dc.title.en":["Relationship between cognitive impairment and obesity"],"dc.title.ru_RU":["Взаимосвязь когнитивных нарушений и ожирения"],"dc.title.alternative":["Relationship between cognitive impairment and obesity","Взаимосвязь когнитивных нарушений и ожирения"],"dc.title.alternative.en":["Relationship between cognitive impairment and obesity"],"dc.title.alternative.ru_RU":["Взаимосвязь когнитивных нарушений и ожирения"],"dc.type":["Article"],"dc.type.ru_RU":["Article"],"publication_grp":["123456789/8788"],"bi_2_dis_filter":["kamaltdinova, gulnara j.\n|||\nKamaltdinova, Gulnara J.","mutalova, elvira g.\n|||\nMutalova, Elvira G.","musina, flarisa s.\n|||\nMusina, Flarisa S.","rustyamova, zulfiya ya.\n|||\nRustyamova, Zulfiya Ya.","камалтдинова, г.я.\n|||\nКамалтдинова, Г.Я.","nigmatullina, albina e.\n|||\nNigmatullina, Albina E.","нафикова, а.и.\n|||\nНафикова, А.И.","муталова, э.г.\n|||\nМуталова, Э.Г.","асадуллина, г.в.\n|||\nАсадуллина, Г.В.","рустямова, з.я.\n|||\nРустямова, З.Я.","sadikova, regina i.\n|||\nSadikova, Regina I.","galyautdinova, velena r.\n|||\nGalyautdinova, Velena R.","asadullina, gulnara v.\n|||\nAsadullina, Gulnara V.","нигматуллина, а.э.\n|||\nНигматуллина, А.Э.","samigullina, liana i.\n|||\nSamigullina, Liana I.","фрид, с.а.\n|||\nФрид, С.А.","nafikova, azalia i.\n|||\nNafikova, Azalia I.","садикова, р.и.\n|||\nСадикова, Р.И.","самигуллина, л.и.\n|||\nСамигуллина, Л.И.","frid, svetlana a.\n|||\nFrid, Svetlana A.","галяутдинова, в.р.\n|||\nГаляутдинова, В.Р.","жуманиязова, а.а.\n|||\nЖуманиязова, А.А.","zhumaniyazova, altinai a.\n|||\nZhumaniyazova, Altinai A.","мусина, ф.с.\n|||\nМусина, Ф.С."],"bi_2_dis_partial":["Асадуллина, Г.В.","Mutalova, Elvira G.","Zhumaniyazova, Altinai A.","Муталова, Э.Г.","Rustyamova, Zulfiya Ya.","Фрид, С.А.","Нафикова, А.И.","Самигуллина, Л.И.","Мусина, Ф.С.","Asadullina, Gulnara V.","Камалтдинова, Г.Я.","Галяутдинова, В.Р.","Садикова, Р.И.","Musina, Flarisa S.","Galyautdinova, Velena R.","Frid, Svetlana A.","Жуманиязова, А.А.","Sadikova, Regina 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These tumors present significant challenges due to their diverse molecular"],"dc.description.abstract.en":[" nervous system lymphomas. These tumors present significant challenges due to their diverse molecular"],"dc.description.abstract_hl":[" nervous system lymphomas. These tumors present significant challenges due to their diverse molecular"]},"2-7741":{"dc.title.en":["The functions of immune system-derived miRNAs in cardiovascular diseases"],"dc.description.abstract":[" of the potential of immune system-derived miRNAs to revolutionize CVD management and therapy, addressing a major"],"dc.title":["The functions of immune system-derived miRNAs in cardiovascular diseases"],"dc.title_hl":["The functions of immune system-derived miRNAs in cardiovascular diseases"],"dc.title_mlt":["The functions of immune system-derived miRNAs in cardiovascular diseases"],"bi_4_dis_partial":["Immune system cells"],"dc.description.abstract.en":[" of the potential of immune system-derived miRNAs to revolutionize CVD management and therapy, addressing a major"],"dc.subject.en":["Immune system cells"],"dc.title.alternative.en":["The functions of immune system-derived miRNAs in cardiovascular diseases"],"title":["The functions of immune system-derived miRNAs in cardiovascular diseases"],"dc.description.abstract_hl":[" of the potential of immune system-derived miRNAs to revolutionize CVD management and therapy, addressing a major"],"dc.subject":["Immune system cells"],"dc.subject_mlt":["Immune system cells"],"subject":["Immune system cells"],"dc.title.alternative":["The functions of immune system-derived miRNAs in cardiovascular diseases"]},"2-7937":{"dc.title.en":[" Management Tactics"],"dc.description.abstract":[". Clinical decision support systems offer a solution to this issue by employing intelligent algorithms"],"dc.title":[" Management Tactics"],"dc.title_hl":[" Management Tactics"],"dc.title_mlt":[" Management Tactics"],"dc.description.abstract.en":[". Clinical decision support systems offer a solution to this issue by employing intelligent algorithms"],"dc.title.alternative.en":[" Management Tactics"],"title":[" Management Tactics"],"dc.description.abstract_hl":[". Clinical decision support systems offer a solution to this issue by employing intelligent algorithms"],"dc.title.alternative":[" Management Tactics"]},"2-7926":{"dc.description.abstract":[" was conducted for data on changes in the expression of specific microRNAs derived from transposons during aging"],"bi_4_dis_partial":["immune system"],"dc.description.abstract.en":[" was conducted for data on changes in the expression of specific microRNAs derived from transposons during aging"],"dc.subject.en":["immune system"],"dc.description.abstract_hl":[" was conducted for data on changes in the expression of specific microRNAs derived from transposons during aging"],"dc.subject":["immune system"],"dc.subject_mlt":["immune system"],"subject":["immune system"]},"2-7888":{"dc.description.abstract":["Introduction: Prostate cancer (PCa) management poses challenges due to treatment"],"dc.description.abstract.en":["Introduction: Prostate cancer (PCa) management poses challenges due to treatment"],"dc.description.abstract_hl":["Introduction: Prostate cancer (PCa) management poses challenges due to treatment"]},"2-7889":{"dc.title.en":["The role of oral microbiota in the etiology, pathogenesis of periodontitis and systemic pathology"],"dc.title":["The role of oral microbiota in the etiology, pathogenesis of periodontitis and systemic pathology"],"dc.title_hl":["The role of oral microbiota in the etiology, pathogenesis of periodontitis and systemic pathology"],"dc.title_mlt":["The role of oral microbiota in the etiology, pathogenesis of periodontitis and systemic pathology"],"dc.title.alternative.en":["The role of oral microbiota in the etiology, pathogenesis of periodontitis and systemic pathology"],"title":["The role of oral microbiota in the etiology, pathogenesis of periodontitis and systemic pathology"],"dc.abstract.en":["Annotation. This review presents an analysis of modern data on the role of oral microbiota"],"dc.title.alternative":["The role of oral microbiota in the etiology, pathogenesis of periodontitis and systemic pathology"],"dc.abstract":["Annotation. This review presents an analysis of modern data on the role of oral microbiota"]},"2-7906":{"dc.description.abstract":["Background and objective: Contemporary data are limited regarding the clinical practice"],"dc.description.abstract.en":["Background and objective: Contemporary data are limited regarding the clinical practice"],"dc.description.abstract_hl":["Background and objective: Contemporary data are limited regarding the clinical practice"]},"2-8043":{"dc.title.en":["Systemic Benign Lipomatosis (Madelung’s Disease): Experience of Surgical Treatment. Clinical Case"],"dc.title":["Systemic Benign Lipomatosis (Madelung’s Disease): Experience of Surgical Treatment. Clinical Case"],"dc.title_hl":["Systemic Benign Lipomatosis (Madelung’s Disease): Experience of Surgical Treatment. Clinical Case"],"dc.title_mlt":["Systemic Benign Lipomatosis (Madelung’s Disease): Experience of Surgical Treatment. Clinical Case"],"title":["Systemic Benign Lipomatosis (Madelung’s Disease): Experience of Surgical Treatment. Clinical Case"],"dc.citation.en":[" systemic review. Aesthetic Plast Surg. 2021;45(3):977–86. DOI: 10.1007/s00266-020-02083-5"],"dc.citation.ru":[" systemic review. Aesthetic Plast Surg. 2021;45(3):977–86. DOI: 10.1007/s00266-020-02083-5"],"dc.abstract.en":[" an example of surgical management and subsequent follow-up care for such patients. systemic review. Aesthetic Plast Surg. 2021;45(3):977–86. DOI: 10.1007/s00266-020-02083-5"],"dc.abstract":[" an example of surgical management and subsequent follow-up care for such patients. data also demonstrated"],"dc.description.abstract.en":[" feature observed across all three monocyte subpopulations after chemotherapy. Our data also demonstrated"],"dc.description.abstract_hl":[" feature observed across all three monocyte subpopulations after chemotherapy. Our data also demonstrated"]},"2-7899":{"dc.abstract.en":[" data published in modern literature, which links obesity with cognitive impairment. Materials"],"dc.abstract":[" data published in modern literature, which links obesity with cognitive impairment. Materials"]}}} -->

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89 Всероссийская студенческая научно-практическая конференция с международным участием «Актуальные вопросы теоретической и практической медицины» 19 – 20 мая 2024 годаInternationalization of Medical Education: experience, eroblems, erospects 2023IV Внутривузовской научно-практической конференции «Языки и медицина»I Международный форум "Возможности комплементарной медицины в практике современного врача. Из прошлого - в настоящее! Синергизм традиций и науки" 31 октября - 4 ноября 2024Авторефераты диссертаций (акушерство и гинекология)Авторефераты диссертаций (онкология)Авторефераты диссертаций (хирургия)Актуальные проблемы гигиены, эпидемиологии и дезинфектологии II Международная научно-практическая конференция (7-8 ноября 2024 г.)Башкирский химический журналБГМУ в годы Великой Отечественной войны (1941 - 1945 гг.)Биология- шаг в медицину будущего (15 июня 2024 г.)Вестник Башкирского государственного медицинского университетаВидеоматериалыⅩⅡ Всероссийская научно-практическая офтальмологическая конференция «ОКО - 2024», посвященной 85-летнему юбилею академика М.Т. АзнабаеваДоказательность морфологических исследований в медицине (01 марта 2024 г.)Евразийский Конгресс урологов (24-25 мая 2019 г. Уфа)Инновационные методы и IT-технологии обучения и воспитания в медицинском вузеИнновационные подходы высшего и непрерывного медицинского и фармацевтического образования (16 ноября 2020 г.)История БГМУИстория медицины и здравоохранения: взгляд в будущее (18–22 сентября 2024 г.)Кафедра общественного здоровья и управления здравоохранениемКафедра скорой помощи и медицины катастроф, термической травмы и трансфузиологииКафедра управления и экономики фармацииКафедра фундаментальной и прикладной микробиологииКомпьютерное моделирование физических процессов и новые цифровые технологии в медицине и фармацииКреативная хирургия и онкологияМатериалы IV Евразийского конгресса по лечению сердечно-сосудистых заболеваний, посвященный к 450-летию г.Уфа 29-30 ноября 2024г.Медицинский вестник БашкортостанаМонографииНаучно-практическая конференция «Языковое взаимодействие и интеркультура в коммуникативном пространстве преподавателя» (24 октября 2024г.)Патент на изобретениеПатент на полезную модельПубликации в периодических изданияхПубликации в сборниках научных трудовПубликации в сборниках трудов конференцийПубликации о БГМУСборники научных трудов БГМУТрадиции и новации в подготовке кадров в медицинском вузеФундаментальные и практические вопросы иммунологии и инфектологии (3-5 октября 2018 г.)Фундаментальные и прикладные аспекты иммунологии, генетики и инфектологии (г. Уфа, 13-14 ноября 2020 г.)

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По вашему запросу найдено документов: 61

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New approaches to targeted drug therapy of intracranial tumors

Beylerli, Ozal, Gareev, Ilgiz, Musaev, Elmar, Roumiantsev, Sergey, Chekhonin, Vladimir, Ahmad, Aamir, Chao, Yuan, Yang, Guang (2025)

nervous system lymphomas. These tumors present significant challenges due to their diverse molecular

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The functions of immune system-derived miRNAs in cardiovascular diseases

Sufianov, Albert, Agaverdiev, Murad, Mashkin, Andrey, Ilyasova, Tatiana (2025)

of the potential of immune system-derived miRNAs to revolutionize CVD management and therapy, addressing a major

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Hybrid Integent Staging of Age-Related Macular Degeneration for Decision-Making on Patient Management Tactics

Lopukhova, Ekaterina A., Yusupov, Ernest S., Ibragimova, Rada R., Idrisova, Gulnaz M., Mukhamadeev, Timur R., Grakhova, Elizaveta P., Kutluyarov, Ruslan V. (2025)

. Clinical decision support systems offer a solution to this issue by employing intelligent algorithms

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Relationship of MicroRNAs to Transposons in Osteoarthritis Development

Mustafin, R.N., Khusnutdinova, E.K. (2025)

was conducted for data on changes in the expression of specific microRNAs derived from transposons during aging

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New kids on the block: MRI guided transrectal focused US, TULSA, focal laser ablation, histotripsy – a comprehensive review

Sangeet, Ghai,, Ni, Tiffany T., Pavlovich, Christian P., Futterer, Jurgen J., Schade, George R., Sanchez-Salas, Rafael, Cornud, Francois, Eggener, Scott, Feller, John F., George, Arvin K., Villers, Arnauld, de la Rosette, Jean (2025)

Introduction: Prostate cancer (PCa) management poses challenges due to treatment

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Роль оральной микробиоты в этиологии, патогенезе пародонтита и в системной патологии

The role of oral microbiota in the etiology, pathogenesis of periodontitis and systemic pathology

Gimranova, I.A., Gritsenko, V.A., Rabinovich, I.M., Akmalova, G.M., Shvets, D.Yu., Гимранова, И.А., Гриценко, В.А., Рабинович, И.М., Акмалова, Г.М., Швец, Д.Ю. (2025)

The role of oral microbiota in the etiology, pathogenesis of periodontitis and systemic pathology

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Impact of Antiaggregant and Anticoagulant Medications on Perioperative Complications in Upper Tract Urothelial Carcinoma

Liu, Kang, Wong, Chris Ho-Ming, Zhao, Hongda, Ng, Chi Fai, Teoh, Jeremy Yuen-Chun, Laguna, Pilar (2025)

Background and objective: Contemporary data are limited regarding the clinical practice

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G(8344) mutation as the only manifestation of disease in a carrier of myoclonus epilepsy and ragged-red fibers (MERRF) syndrome. Am J Hum Genet. 1993r;52(3):551–6. PMID: 8447321" [11]=> string(289) "Мазунин И.О., Володько Н.В., Стариковская Е.Б., Сукерник Р.И. Митохондриальный геном и митохондриальные заболевания человека. Молекулярная биология. 2010;44(5):755–72." [12]=> string(201) "Celentano V., Esposito E., Perrotta S., Giglio M.C., Tarquini R., Luglio G., et al. Madelung disease: report of a case and review of the literature. Acta Chir Belg. 2014;114(6):417–20. PMID: 26021689" [13]=> string(191) "Lemaitre M., Chevalier B., Jannin A., Bourry J., Espiard S., Vantyghem M.C. Multiple symmetric and multiple familial lipomatosis. Presse Med. 2021;50(3):104077. DOI: 10.1016/j.lpm.2021.104077" [14]=> string(494) "Вецмадян Е.А., Труфанов Г.Е., Рязанов В.В., Мостовая О.Т., Новиков К.В., Карайванов Н.С. Ультразвуковая диагностика липом мягких тканей с использованием методик цветного допплеровского картирования и эластографии. Вестник Российской Военно-медицинской академии. 2012;2(38):43–50." [15]=> string(227) "Богов А.А., Андреев П.С., Филиппов В.Л., Топыркин В.Г. Оперативное лечение болезни Маделунга. Практическая медицина. 2018;16(7-1):90–3." [16]=> string(324) "Уракова Е.В., Нестеров О.В., Ильина Р.Ю., Лексин Р.В. Хирургическая тактика при рецидивирующем липоматозе (болезни Маделунга). Клинический случай. Практическая медицина. 2022;20(6):131–3." [17]=> string(527) "Егай А.А., Тентимишев А.Э., Норматов Р.М., Тян А.С. Хирургическое лечение множественного симметричного липоматоза (болезнь Маделунга), осложненного сдавлением яремных вен с обеих сторон. Преимущества липэктомии перед липосакцией. Научное обозрение. Медицинские науки. 2022;1:5– 10. DOI: 10.17513/srms.1225" [18]=> string(379) "Тимербулатов М.В., Шорнина А.С., Лихтер Р.А., Каипов А.Э. 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Modified dome osteotomy and anterior locking plate fixation for distal radius variant of Madelung deformity: a retrospective study. J Plast Surg Hand Surg. 2022;56(2):121–6. 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Системный доброкачественный липоматоз (болезнь Маделунга): опыт хирургического лечения (клинический случай)

Systemic Benign Lipomatosis (Madelung’s Disease): Experience of Surgical Treatment. Clinical Case

А. М. Суздальцев, A. M. Suzdaltsev, В. М. Гершевич, V. M. Gershevich, С. В. Черненко, S. V. Chernenko, Д. В. Земкаюс, D. V. Zemkayus, О. В. Балюра, O. V. Balura, Р. В. Еселевич, R. V. Eselevich, Д. А. Рудаков, D. A. Rudakov (Креативная хирургия и онкология, №2, 2025)

Systemic Benign Lipomatosis (Madelung’s Disease): Experience of Surgical Treatment. Clinical Case

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Platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma

Larionova, Irina, Iamshchikov, Pavel, Kazakova, Anna, Rakina, Militsa, Menyalo, Maxim, Enikeeva, Kadriia, Rafikova, Guzel, Sharifyanova, Yuliya, Pavlov, Valentin, Villert, Alisa, Kolomiets, Larisa, Kzhyshkowska, Julia (2025)

feature observed across all three monocyte subpopulations after chemotherapy. Our data also demonstrated

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Взаимосвязь когнитивных нарушений и ожирения

Relationship between cognitive impairment and obesity

Mutalova, Elvira G., Nafikova, Azalia I., Nigmatullina, Albina E., Galyautdinova, Velena R., Kamaltdinova, Gulnara J., Asadullina, Gulnara V., Samigullina, Liana I., Rustyamova, Zulfiya Ya., Sadikova, Regina I., Frid, Svetlana A., Musina, Flarisa S., Zhumaniyazova, Altinai A., Муталова, Э.Г., Нафикова, А.И., Нигматуллина, А.Э., Галяутдинова, В.Р., Камалтдинова, Г.Я., Асадуллина, Г.В., Самигуллина, Л.И., Рустямова, З.Я., Садикова, Р.И., Фрид, С.А., Мусина, Ф.С., Жуманиязова, А.А. (2025)

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