G(8344) mutation as the only manifestation of disease in a carrier of myoclonus epilepsy and ragged-red fibers (MERRF) syndrome. Am J Hum Genet. 1993r;52(3):551–6. PMID: 8447321","Мазунин И.О., Володько Н.В., Стариковская Е.Б., Сукерник Р.И. Митохондриальный геном и митохондриальные заболевания человека. Молекулярная биология. 2010;44(5):755–72.","Celentano V., Esposito E., Perrotta S., Giglio M.C., Tarquini R., Luglio G., et al. Madelung disease: report of a case and review of the literature. Acta Chir Belg. 2014;114(6):417–20. PMID: 26021689","Lemaitre M., Chevalier B., Jannin A., Bourry J., Espiard S., Vantyghem M.C. Multiple symmetric and multiple familial lipomatosis. Presse Med. 2021;50(3):104077. DOI: 10.1016/j.lpm.2021.104077","Вецмадян Е.А., Труфанов Г.Е., Рязанов В.В., Мостовая О.Т., Новиков К.В., Карайванов Н.С. Ультразвуковая диагностика липом мягких тканей с использованием методик цветного допплеровского картирования и эластографии. Вестник Российской Военно-медицинской академии. 2012;2(38):43–50.","Богов А.А., Андреев П.С., Филиппов В.Л., Топыркин В.Г. Оперативное лечение болезни Маделунга. Практическая медицина. 2018;16(7-1):90–3.","Уракова Е.В., Нестеров О.В., Ильина Р.Ю., Лексин Р.В. Хирургическая тактика при рецидивирующем липоматозе (болезни Маделунга). Клинический случай. Практическая медицина. 2022;20(6):131–3.","Егай А.А., Тентимишев А.Э., Норматов Р.М., Тян А.С. Хирургическое лечение множественного симметричного липоматоза (болезнь Маделунга), осложненного сдавлением яремных вен с обеих сторон. Преимущества липэктомии перед липосакцией. Научное обозрение. Медицинские науки. 2022;1:5– 10. DOI: 10.17513/srms.1225","Тимербулатов М.В., Шорнина А.С., Лихтер Р.А., Каипов А.Э. Оценка липосакции в структуре абдоминопластики и сочетанной герниоабдоминопластики. Креативная хирургия и онкология. 2023;13(4):278–83. DOI: 10.24060/2076-3093-2023-13-4-278-283","Dang Y., Du X., Ou X., Zheng Q., Xie F. Advances in diagnosis and treatment of Madelung’s deformity. Am J Transl Res. 2023;15(7):4416–24.","Leti Acciaro A, Garagnani L, Lando M, Lana D, Sartini S, Adani R. Modified dome osteotomy and anterior locking plate fixation for distal radius variant of Madelung deformity: a retrospective study. J Plast Surg Hand Surg. 2022;56(2):121–6. DOI: 10.1080/2000656X.2021.1934845","Liu Q., Lyu H., Xu B., Lee J.H. Madelung disease epidemiology and clinical characteristics: a systemic review. Aesthetic Plast Surg. 2021;45(3):977–86. DOI: 10.1007/s00266-020-02083-5","Sia K.J., Tang I.P., Tan T.Y. Multiple symmetrical lipomatosis: case report and literature review. J Laryngol Otol. 2012;126(7):756–8. DOI: 10.1017/S0022215112000709","Kratz C., Lenard H.G., Ruzicka T., Gärtner J. Multiple symmetric lipomatosis: an unusual cause of childhood obesity and mental retardation. Eur J Paediatr Neurol. 2000;4(2):63–7. DOI: 10.1053/ejpn.2000.0264","Nounla J., Rolle U., Gräfe G., Kräling K. Benign symmetric lipomatosis with myelomeningocele in an adolescent: An uncommon association-case report. J Pediatr Surg. 2001;36(7):E13. DOI: 10.1053/jpsu.2001.24776","Madelung O.W. Über den Fetthals (diffuses Lipom des Halses). Arch Klin Chir. 1888;37:106-30.","Lanois P.E., Bensaude R. De ladeno-lipomatosesymetrique. Bull Mem Soc Med Hosp. 1898;1:298.","El Ouahabi H., Doubi S., Lahlou K., Boujraf S., Ajdi F. Launois-bensaude syndrome: A benign symmetric lipomatosis without alcohol association. Ann Afr Med. 2017;16(1):33–4. DOI: 10.4103/1596-3519.202082","Chen C.Y., Fang Q.Q., Wang X.F., Zhang M.X., Zhao W.Y., Shi B.H., et al. Madelung’s disease: lipectomy or liposuction? Biomed Res Int. 2018;3975974. DOI: 10.1155/2018/3975974","Coker J.E., Bryan J.A. Endocrine and metabolic disorders: Causes and pathogenesis of obesity. J. Fam. Pract. 2008;4:21–6.","González-García R., Rodríguez-Campo F.J., Sastre-Pérez J., Muñoz-Guerra M.F. Benign symmetric lipomatosis (Madelung’s disease): case reports and current management. Aesthetic Plast Surg. 2004;28(2):108– 12; discussion 113. DOI: 10.1007/s00266-004-3123-5","Holme E., Larsson N.G., Oldfors A., Tulinius M., Sahlin P., Stenman G. Multiple symmetric lipomas with high levels of mtDNA with the tRNA(Lys) A-->G(8344) mutation as the only manifestation of disease in a carrier of myoclonus epilepsy and ragged-red fibers (MERRF) syndrome. Am J Hum Genet. 1993r;52(3):551–6. PMID: 8447321","Мазунин И.О., Володько Н.В., Стариковская Е.Б., Сукерник Р.И. Митохондриальный геном и митохондриальные заболевания человека. Молекулярная биология. 2010;44(5):755–72.","Celentano V., Esposito E., Perrotta S., Giglio M.C., Tarquini R., Luglio G., et al. Madelung disease: report of a case and review of the literature. Acta Chir Belg. 2014;114(6):417–20. PMID: 26021689","Lemaitre M., Chevalier B., Jannin A., Bourry J., Espiard S., Vantyghem M.C. Multiple symmetric and multiple familial lipomatosis. Presse Med. 2021;50(3):104077. DOI: 10.1016/j.lpm.2021.104077","Вецмадян Е.А., Труфанов Г.Е., Рязанов В.В., Мостовая О.Т., Новиков К.В., Карайванов Н.С. Ультразвуковая диагностика липом мягких тканей с использованием методик цветного допплеровского картирования и эластографии. Вестник Российской Военно-медицинской академии. 2012;2(38):43–50.","Богов А.А., Андреев П.С., Филиппов В.Л., Топыркин В.Г. Оперативное лечение болезни Маделунга. Практическая медицина. 2018;16(7-1):90–3.","Уракова Е.В., Нестеров О.В., Ильина Р.Ю., Лексин Р.В. Хирургическая тактика при рецидивирующем липоматозе (болезни Маделунга). Клинический случай. Практическая медицина. 2022;20(6):131–3.","Егай А.А., Тентимишев А.Э., Норматов Р.М., Тян А.С. Хирургическое лечение множественного симметричного липоматоза (болезнь Маделунга), осложненного сдавлением яремных вен с обеих сторон. Преимущества липэктомии перед липосакцией. Научное обозрение. Медицинские науки. 2022;1:5– 10. DOI: 10.17513/srms.1225","Тимербулатов М.В., Шорнина А.С., Лихтер Р.А., Каипов А.Э. Оценка липосакции в структуре абдоминопластики и сочетанной герниоабдоминопластики. Креативная хирургия и онкология. 2023;13(4):278–83. DOI: 10.24060/2076-3093-2023-13-4-278-283","Dang Y., Du X., Ou X., Zheng Q., Xie F. Advances in diagnosis and treatment of Madelung’s deformity. Am J Transl Res. 2023;15(7):4416–24.","Leti Acciaro A, Garagnani L, Lando M, Lana D, Sartini S, Adani R. Modified dome osteotomy and anterior locking plate fixation for distal radius variant of Madelung deformity: a retrospective study. J Plast Surg Hand Surg. 2022;56(2):121–6. DOI: 10.1080/2000656X.2021.1934845"],"dc.citation.ru":["Liu Q., Lyu H., Xu B., Lee J.H. Madelung disease epidemiology and clinical characteristics: a systemic review. Aesthetic Plast Surg. 2021;45(3):977–86. DOI: 10.1007/s00266-020-02083-5","Sia K.J., Tang I.P., Tan T.Y. Multiple symmetrical lipomatosis: case report and literature review. J Laryngol Otol. 2012;126(7):756–8. DOI: 10.1017/S0022215112000709","Kratz C., Lenard H.G., Ruzicka T., Gärtner J. Multiple symmetric lipomatosis: an unusual cause of childhood obesity and mental retardation. Eur J Paediatr Neurol. 2000;4(2):63–7. DOI: 10.1053/ejpn.2000.0264","Nounla J., Rolle U., Gräfe G., Kräling K. Benign symmetric lipomatosis with myelomeningocele in an adolescent: An uncommon association-case report. J Pediatr Surg. 2001;36(7):E13. DOI: 10.1053/jpsu.2001.24776","Madelung O.W. Über den Fetthals (diffuses Lipom des Halses). Arch Klin Chir. 1888;37:106-30.","Lanois P.E., Bensaude R. De ladeno-lipomatosesymetrique. Bull Mem Soc Med Hosp. 1898;1:298.","El Ouahabi H., Doubi S., Lahlou K., Boujraf S., Ajdi F. Launois-bensaude syndrome: A benign symmetric lipomatosis without alcohol association. Ann Afr Med. 2017;16(1):33–4. DOI: 10.4103/1596-3519.202082","Chen C.Y., Fang Q.Q., Wang X.F., Zhang M.X., Zhao W.Y., Shi B.H., et al. Madelung’s disease: lipectomy or liposuction? Biomed Res Int. 2018;3975974. DOI: 10.1155/2018/3975974","Coker J.E., Bryan J.A. Endocrine and metabolic disorders: Causes and pathogenesis of obesity. J. Fam. Pract. 2008;4:21–6.","González-García R., Rodríguez-Campo F.J., Sastre-Pérez J., Muñoz-Guerra M.F. Benign symmetric lipomatosis (Madelung’s disease): case reports and current management. Aesthetic Plast Surg. 2004;28(2):108– 12; discussion 113. DOI: 10.1007/s00266-004-3123-5","Holme E., Larsson N.G., Oldfors A., Tulinius M., Sahlin P., Stenman G. Multiple symmetric lipomas with high levels of mtDNA with the tRNA(Lys) A-->G(8344) mutation as the only manifestation of disease in a carrier of myoclonus epilepsy and ragged-red fibers (MERRF) syndrome. Am J Hum Genet. 1993r;52(3):551–6. PMID: 8447321","Мазунин И.О., Володько Н.В., Стариковская Е.Б., Сукерник Р.И. Митохондриальный геном и митохондриальные заболевания человека. Молекулярная биология. 2010;44(5):755–72.","Celentano V., Esposito E., Perrotta S., Giglio M.C., Tarquini R., Luglio G., et al. Madelung disease: report of a case and review of the literature. Acta Chir Belg. 2014;114(6):417–20. PMID: 26021689","Lemaitre M., Chevalier B., Jannin A., Bourry J., Espiard S., Vantyghem M.C. Multiple symmetric and multiple familial lipomatosis. Presse Med. 2021;50(3):104077. DOI: 10.1016/j.lpm.2021.104077","Вецмадян Е.А., Труфанов Г.Е., Рязанов В.В., Мостовая О.Т., Новиков К.В., Карайванов Н.С. Ультразвуковая диагностика липом мягких тканей с использованием методик цветного допплеровского картирования и эластографии. Вестник Российской Военно-медицинской академии. 2012;2(38):43–50.","Богов А.А., Андреев П.С., Филиппов В.Л., Топыркин В.Г. Оперативное лечение болезни Маделунга. Практическая медицина. 2018;16(7-1):90–3.","Уракова Е.В., Нестеров О.В., Ильина Р.Ю., Лексин Р.В. Хирургическая тактика при рецидивирующем липоматозе (болезни Маделунга). Клинический случай. Практическая медицина. 2022;20(6):131–3.","Егай А.А., Тентимишев А.Э., Норматов Р.М., Тян А.С. Хирургическое лечение множественного симметричного липоматоза (болезнь Маделунга), осложненного сдавлением яремных вен с обеих сторон. Преимущества липэктомии перед липосакцией. Научное обозрение. Медицинские науки. 2022;1:5– 10. DOI: 10.17513/srms.1225","Тимербулатов М.В., Шорнина А.С., Лихтер Р.А., Каипов А.Э. Оценка липосакции в структуре абдоминопластики и сочетанной герниоабдоминопластики. Креативная хирургия и онкология. 2023;13(4):278–83. DOI: 10.24060/2076-3093-2023-13-4-278-283","Dang Y., Du X., Ou X., Zheng Q., Xie F. Advances in diagnosis and treatment of Madelung’s deformity. Am J Transl Res. 2023;15(7):4416–24.","Leti Acciaro A, Garagnani L, Lando M, Lana D, Sartini S, Adani R. Modified dome osteotomy and anterior locking plate fixation for distal radius variant of Madelung deformity: a retrospective study. J Plast Surg Hand Surg. 2022;56(2):121–6. DOI: 10.1080/2000656X.2021.1934845"],"dc.citation.en":["Liu Q., Lyu H., Xu B., Lee J.H. Madelung disease epidemiology and clinical characteristics: a systemic review. Aesthetic Plast Surg. 2021;45(3):977–86. DOI: 10.1007/s00266-020-02083-5","Sia K.J., Tang I.P., Tan T.Y. Multiple symmetrical lipomatosis: case report and literature review. J Laryngol Otol. 2012;126(7):756–8. DOI: 10.1017/S0022215112000709","Kratz C., Lenard H.G., Ruzicka T., Gärtner J. Multiple symmetric lipomatosis: an unusual cause of childhood obesity and mental retardation. Eur J Paediatr Neurol. 2000;4(2):63–7. DOI: 10.1053/ejpn.2000.0264","Nounla J., Rolle U., Gräfe G., Kräling K. Benign symmetric lipomatosis with myelomeningocele in an adolescent: An uncommon association-case report. J Pediatr Surg. 2001;36(7):E13. DOI: 10.1053/jpsu.2001.24776","Madelung O.W. Über den Fetthals (diffuses Lipom des Halses). Arch Klin Chir. 1888;37:106-30.","Lanois P.E., Bensaude R. De ladeno-lipomatosesymetrique. Bull Mem Soc Med Hosp. 1898;1:298.","El Ouahabi H., Doubi S., Lahlou K., Boujraf S., Ajdi F. Launois-bensaude syndrome: A benign symmetric lipomatosis without alcohol association. Ann Afr Med. 2017;16(1):33–4. DOI: 10.4103/1596-3519.202082","Chen C.Y., Fang Q.Q., Wang X.F., Zhang M.X., Zhao W.Y., Shi B.H., et al. Madelung’s disease: lipectomy or liposuction? Biomed Res Int. 2018;3975974. DOI: 10.1155/2018/3975974","Coker J.E., Bryan J.A. Endocrine and metabolic disorders: Causes and pathogenesis of obesity. J. Fam. Pract. 2008;4:21–6.","González-García R., Rodríguez-Campo F.J., Sastre-Pérez J., Muñoz-Guerra M.F. Benign symmetric lipomatosis (Madelung’s disease): case reports and current management. Aesthetic Plast Surg. 2004;28(2):108– 12; discussion 113. DOI: 10.1007/s00266-004-3123-5","Holme E., Larsson N.G., Oldfors A., Tulinius M., Sahlin P., Stenman G. Multiple symmetric lipomas with high levels of mtDNA with the tRNA(Lys) A-->G(8344) mutation as the only manifestation of disease in a carrier of myoclonus epilepsy and ragged-red fibers (MERRF) syndrome. Am J Hum Genet. 1993r;52(3):551–6. PMID: 8447321","Мазунин И.О., Володько Н.В., Стариковская Е.Б., Сукерник Р.И. Митохондриальный геном и митохондриальные заболевания человека. Молекулярная биология. 2010;44(5):755–72.","Celentano V., Esposito E., Perrotta S., Giglio M.C., Tarquini R., Luglio G., et al. Madelung disease: report of a case and review of the literature. Acta Chir Belg. 2014;114(6):417–20. PMID: 26021689","Lemaitre M., Chevalier B., Jannin A., Bourry J., Espiard S., Vantyghem M.C. Multiple symmetric and multiple familial lipomatosis. Presse Med. 2021;50(3):104077. DOI: 10.1016/j.lpm.2021.104077","Вецмадян Е.А., Труфанов Г.Е., Рязанов В.В., Мостовая О.Т., Новиков К.В., Карайванов Н.С. Ультразвуковая диагностика липом мягких тканей с использованием методик цветного допплеровского картирования и эластографии. Вестник Российской Военно-медицинской академии. 2012;2(38):43–50.","Богов А.А., Андреев П.С., Филиппов В.Л., Топыркин В.Г. Оперативное лечение болезни Маделунга. Практическая медицина. 2018;16(7-1):90–3.","Уракова Е.В., Нестеров О.В., Ильина Р.Ю., Лексин Р.В. Хирургическая тактика при рецидивирующем липоматозе (болезни Маделунга). Клинический случай. Практическая медицина. 2022;20(6):131–3.","Егай А.А., Тентимишев А.Э., Норматов Р.М., Тян А.С. Хирургическое лечение множественного симметричного липоматоза (болезнь Маделунга), осложненного сдавлением яремных вен с обеих сторон. Преимущества липэктомии перед липосакцией. Научное обозрение. Медицинские науки. 2022;1:5– 10. DOI: 10.17513/srms.1225","Тимербулатов М.В., Шорнина А.С., Лихтер Р.А., Каипов А.Э. Оценка липосакции в структуре абдоминопластики и сочетанной герниоабдоминопластики. Креативная хирургия и онкология. 2023;13(4):278–83. DOI: 10.24060/2076-3093-2023-13-4-278-283","Dang Y., Du X., Ou X., Zheng Q., Xie F. Advances in diagnosis and treatment of Madelung’s deformity. Am J Transl Res. 2023;15(7):4416–24.","Leti Acciaro A, Garagnani L, Lando M, Lana D, Sartini S, Adani R. Modified dome osteotomy and anterior locking plate fixation for distal radius variant of Madelung deformity: a retrospective study. J Plast Surg Hand Surg. 2022;56(2):121–6. DOI: 10.1080/2000656X.2021.1934845"],"dc.identifier.uri":["http://hdl.handle.net/123456789/8932"],"dc.date.accessioned_dt":"2025-07-09T13:59:02Z","dc.date.accessioned":["2025-07-09T13:59:02Z"],"dc.date.available":["2025-07-09T13:59:02Z"],"publication_grp":["123456789/8932"],"bi_4_dis_filter":["madelung’s disease\n|||\nMadelung’s disease","lipectomy\n|||\nlipectomy","диффузный симметричный липоматоз\n|||\nдиффузный симметричный липоматоз","шеи новообразования\n|||\nшеи новообразования","липэктомия\n|||\nлипэктомия","diffuse symmetric lipomatosis\n|||\ndiffuse symmetric lipomatosis","adipose tissue proliferation\n|||\nadipose tissue proliferation","жировой ткани разрастание\n|||\nжировой ткани разрастание","болезнь маделунга\n|||\nболезнь Маделунга","neck neoplasms\n|||\nneck neoplasms"],"bi_4_dis_partial":["липэктомия","Madelung’s disease","diffuse symmetric lipomatosis","neck neoplasms","болезнь Маделунга","adipose tissue proliferation","шеи новообразования","lipectomy","диффузный симметричный липоматоз","жировой ткани разрастание"],"bi_4_dis_value_filter":["липэктомия","Madelung’s disease","diffuse symmetric lipomatosis","neck neoplasms","болезнь Маделунга","adipose tissue proliferation","шеи новообразования","lipectomy","диффузный симметричный липоматоз","жировой ткани разрастание"],"bi_sort_1_sort":"systemic benign lipomatosis (madelung’s disease): experience of surgical treatment. clinical case","bi_sort_3_sort":"2025-07-09T13:59:02Z","read":["g0"],"_version_":1837178072511545344},{"SolrIndexer.lastIndexed":"2025-04-28T11:10:33.976Z","search.uniqueid":"2-7897","search.resourcetype":2,"search.resourceid":7897,"handle":"123456789/8786","location":["m229","l684"],"location.comm":["229"],"location.coll":["684"],"withdrawn":"false","discoverable":"true","dc.abstract":["Wegener’s granulomatosis (WG) or granulomatosis with polyangiitis is a primary systemic necrotizing vasculitis of small and medium-sized vessels with the development of foci of granulomatous inflammation. This is a severe, progressive, presumably autoimmune disease associated with antineutrophil cytoplasmic antibodies, which is detected mainly in people over 50 years of age. In the absence of timely treatment — immunosuppressive therapy (steroids and cytostatics to suppress disease activity, maintain remission and treat relapses), it can lead to the death of the patient. In the WG clinic, it begins with symptoms characteristic for respiratory infection, the lesions of the upper respiratory tract (rhinitis, nasopharyngitis, etc.), eyes, lungs (fibrosis, pleurisy, etc.) and kidneys (glomerulonephritis) prevail. One of the organs that are quite often (in about half of patients) affected by this disease, and, mainly, already in the early stages is the eye. With its defeat, in some cases, WG can even begin, but more and more often the eye is involved against the background of the development and long-term course of the inflammatory process of the upper respiratory tract and/or the first developed purulent inflammation of the middle ear in adult patients and nasal sinuses. In WG, any part of the eye can be affected, most often the anterior (most often scleritis, keratitis, less often — a corneal ulcer, etc.) and much less often — the posterior, and both in the form of a slight inflammation of the membranes of the eye to severe involvement of all its structures and orbit (pseudotumor) with the occurrence of low vision and even complete blindness. Difficulties in the diagnosis of WG usually arise due to the variety of forms and variants of the clinical course in the early stages of the disease, when ophthalmic changes are still of little specificity, and systemic ones are practically absent. Our clinical case of WG in a 62-year-old patient indicates that the diagnosis of this disease is far from simple and takes a very long period of time. Although the presence of episleritis/scleritis with a refractory course of the pathological process, especially if the patient had a history of bilateral purulent otitis media suffered by the patient and an infiltrate in the lungs, regarded, despite the biopsy during the first analysis, as a manifestation of atypical pneumonia, should already have alerted doctors to regarding the diagnosis of WG. Unfortunately, only severe dysphagia prompted the patient to be urgently hospitalized, to examine her as much as possible with a second revision of the previously taken lung biopsy material and to make the right decision in favor of the diagnosis of WG with the appointment of subsequent adequate treatment. © 2025, Real Time LLC. All rights reserved."],"dc.abstract.en":["Wegener’s granulomatosis (WG) or granulomatosis with polyangiitis is a primary systemic necrotizing vasculitis of small and medium-sized vessels with the development of foci of granulomatous inflammation. This is a severe, progressive, presumably autoimmune disease associated with antineutrophil cytoplasmic antibodies, which is detected mainly in people over 50 years of age. In the absence of timely treatment — immunosuppressive therapy (steroids and cytostatics to suppress disease activity, maintain remission and treat relapses), it can lead to the death of the patient. In the WG clinic, it begins with symptoms characteristic for respiratory infection, the lesions of the upper respiratory tract (rhinitis, nasopharyngitis, etc.), eyes, lungs (fibrosis, pleurisy, etc.) and kidneys (glomerulonephritis) prevail. One of the organs that are quite often (in about half of patients) affected by this disease, and, mainly, already in the early stages is the eye. With its defeat, in some cases, WG can even begin, but more and more often the eye is involved against the background of the development and long-term course of the inflammatory process of the upper respiratory tract and/or the first developed purulent inflammation of the middle ear in adult patients and nasal sinuses. In WG, any part of the eye can be affected, most often the anterior (most often scleritis, keratitis, less often — a corneal ulcer, etc.) and much less often — the posterior, and both in the form of a slight inflammation of the membranes of the eye to severe involvement of all its structures and orbit (pseudotumor) with the occurrence of low vision and even complete blindness. Difficulties in the diagnosis of WG usually arise due to the variety of forms and variants of the clinical course in the early stages of the disease, when ophthalmic changes are still of little specificity, and systemic ones are practically absent. Our clinical case of WG in a 62-year-old patient indicates that the diagnosis of this disease is far from simple and takes a very long period of time. Although the presence of episleritis/scleritis with a refractory course of the pathological process, especially if the patient had a history of bilateral purulent otitis media suffered by the patient and an infiltrate in the lungs, regarded, despite the biopsy during the first analysis, as a manifestation of atypical pneumonia, should already have alerted doctors to regarding the diagnosis of WG. Unfortunately, only severe dysphagia prompted the patient to be urgently hospitalized, to examine her as much as possible with a second revision of the previously taken lung biopsy material and to make the right decision in favor of the diagnosis of WG with the appointment of subsequent adequate treatment. © 2025, Real Time LLC. All rights reserved."],"author":["Bikbov, Mukharram M.","Babushkin, Alexander E.","Israfilova, Gulnara Z.","Бикбов, М.М.","Бабушкин, А.Э.","Исрафилова, Г.З."],"author_keyword":["Bikbov, Mukharram M.","Babushkin, Alexander E.","Israfilova, Gulnara Z.","Бикбов, М.М.","Бабушкин, А.Э.","Исрафилова, Г.З."],"author_ac":["bikbov, mukharram m.\n|||\nBikbov, Mukharram M.","babushkin, alexander e.\n|||\nBabushkin, Alexander E.","israfilova, gulnara z.\n|||\nIsrafilova, Gulnara Z.","бикбов, м.м.\n|||\nБикбов, М.М.","бабушкин, а.э.\n|||\nБабушкин, А.Э.","исрафилова, г.з.\n|||\nИсрафилова, Г.З."],"author_filter":["bikbov, mukharram m.\n|||\nBikbov, Mukharram M.","babushkin, alexander e.\n|||\nBabushkin, Alexander E.","israfilova, gulnara z.\n|||\nIsrafilova, Gulnara Z.","бикбов, м.м.\n|||\nБикбов, М.М.","бабушкин, а.э.\n|||\nБабушкин, А.Э.","исрафилова, г.з.\n|||\nИсрафилова, Г.З."],"dc.contributor.author_hl":["Bikbov, Mukharram M.","Babushkin, Alexander E.","Israfilova, Gulnara Z.","Бикбов, М.М.","Бабушкин, А.Э.","Исрафилова, Г.З."],"dc.contributor.author_mlt":["Bikbov, Mukharram M.","Babushkin, Alexander E.","Israfilova, Gulnara Z.","Бикбов, М.М.","Бабушкин, А.Э.","Исрафилова, Г.З."],"dc.contributor.author":["Bikbov, Mukharram M.","Babushkin, Alexander E.","Israfilova, Gulnara Z.","Бикбов, М.М.","Бабушкин, А.Э.","Исрафилова, Г.З."],"dc.contributor.author_stored":["Bikbov, Mukharram M.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Babushkin, Alexander E.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Israfilova, Gulnara Z.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Бикбов, М.М.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nru_RU","Бабушкин, А.Э.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nru_RU","Исрафилова, Г.З.\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nru_RU"],"dc.contributor.author.en":["Bikbov, Mukharram M.","Babushkin, Alexander E.","Israfilova, Gulnara Z."],"dc.contributor.author.ru_RU":["Бикбов, М.М.","Бабушкин, А.Э.","Исрафилова, Г.З."],"dc.date.accessioned_dt":"2025-04-28T11:09:01Z","dc.date.accessioned":["2025-04-28T11:09:01Z"],"dc.date.available":["2025-04-28T11:09:01Z"],"dateIssued":["2025-01-01"],"dateIssued_keyword":["2025-01-01","2025"],"dateIssued_ac":["2025-01-01\n|||\n2025-01-01","2025"],"dateIssued.year":[2025],"dateIssued.year_sort":"2025","dc.date.issued_dt":"2025-01-01T00:00:00Z","dc.date.issued":["2025-01-01"],"dc.date.issued_stored":["2025-01-01\n|||\nnull\n|||\nnull\n|||\nnull\n|||\n"],"dc.description.abstract_hl":["ранулематоз Вегенера (ГВ), или гранулематоз с полиангиитом, представляет собой первичный системный некротизирующий\nваскулит сосудов мелкого и среднего калибра с развитием очагов гранулематозного воспаления. Это тяжелое, прогрессирующее,\nпредположительно аутоиммунное заболевание, ассоциированное с антинейтрофильными цитоплазматическими антителами,\nвыявляется в основном у людей старше 50 лет. При отсутствии своевременного лечения — иммуносупрессивной терапии (стеро-\nиды и цитостатики для подавления активности заболевания, поддержания ремиссии и лечения рецидивов) оно может привести\nк смерти пациента. В клинике ГВ начинается с симптомов, характерных для любой респираторной инфекции, превалирует\nпоражение верхних дыхательных путей (ринит, назофарингит и пр.), глаз, легких (фиброз, плеврит и т. д.) и почек (гломеруло-\nнефрит). Одним из органов, которые довольно часто (примерно у половины пациентов) поражаются при данном заболевании,\nпричем в основном уже на ранних стадиях, является глаз. С его поражения в ряде случаев может даже начинаться ГВ, но все же\nзначительно чаще орган зрения бывает задействован на фоне развития и длительного течения воспалительного процесса верхних\nдыхательных путей и/или впервые развившегося гнойного воспаления среднего уха у взрослых пациентов, носовых пазух. При ГВ\nможет поражаться любой отдел глаза, чаще всего передний (чаще всего склерит, кератит, реже — язва роговицы и пр.) и зна-\nчительно реже — задний, причем как в виде незначительного воспаления оболочек глаза, так и тяжелого вовлечения всех его\nструктур и орбиты (псевдотумор) с возникновением слабовидения и даже полной слепоты. Трудности в диагностике ГВ обычно\nвозникают из-за разнообразия форм и вариантов клинического течения на ранних стадиях заболевания, когда офтальмологиче-\nские изменения еще малоспецифичны, а системные практически отсутствуют. Приведенный клинический случай ГВ у 62-летней\nпациентки показывает, что диагностика данного заболевания происходит далеко не просто и занимает весьма длительный пе-\nриод времени. Хотя наличие эписклерита/склерита с рефрактерным течением патологического процесса, особенно при наличии в\nанамнезе двустороннего гнойного отита, перенесенного пациенткой, и инфильтрата в легких, расцененного, несмотря на биопсию\nпри первом анализе, как проявление нетипично протекающей пневмонии, уже должно было насторожить врачей в отношении\nдиагноза ГВ. К сожалению, только выраженная дисфагия побудила экстренно госпитализировать пациентку, максимально до-\nобследовать ее с повторным пересмотром ранее взятого биопсийного материала легких и принять правильное решение в пользу\nдиагноза ГВ с назначением последующего адекватного лечения."],"dc.description.abstract":["ранулематоз Вегенера (ГВ), или гранулематоз с полиангиитом, представляет собой первичный системный некротизирующий\nваскулит сосудов мелкого и среднего калибра с развитием очагов гранулематозного воспаления. Это тяжелое, прогрессирующее,\nпредположительно аутоиммунное заболевание, ассоциированное с антинейтрофильными цитоплазматическими антителами,\nвыявляется в основном у людей старше 50 лет. При отсутствии своевременного лечения — иммуносупрессивной терапии (стеро-\nиды и цитостатики для подавления активности заболевания, поддержания ремиссии и лечения рецидивов) оно может привести\nк смерти пациента. В клинике ГВ начинается с симптомов, характерных для любой респираторной инфекции, превалирует\nпоражение верхних дыхательных путей (ринит, назофарингит и пр.), глаз, легких (фиброз, плеврит и т. д.) и почек (гломеруло-\nнефрит). Одним из органов, которые довольно часто (примерно у половины пациентов) поражаются при данном заболевании,\nпричем в основном уже на ранних стадиях, является глаз. С его поражения в ряде случаев может даже начинаться ГВ, но все же\nзначительно чаще орган зрения бывает задействован на фоне развития и длительного течения воспалительного процесса верхних\nдыхательных путей и/или впервые развившегося гнойного воспаления среднего уха у взрослых пациентов, носовых пазух. При ГВ\nможет поражаться любой отдел глаза, чаще всего передний (чаще всего склерит, кератит, реже — язва роговицы и пр.) и зна-\nчительно реже — задний, причем как в виде незначительного воспаления оболочек глаза, так и тяжелого вовлечения всех его\nструктур и орбиты (псевдотумор) с возникновением слабовидения и даже полной слепоты. Трудности в диагностике ГВ обычно\nвозникают из-за разнообразия форм и вариантов клинического течения на ранних стадиях заболевания, когда офтальмологиче-\nские изменения еще малоспецифичны, а системные практически отсутствуют. Приведенный клинический случай ГВ у 62-летней\nпациентки показывает, что диагностика данного заболевания происходит далеко не просто и занимает весьма длительный пе-\nриод времени. Хотя наличие эписклерита/склерита с рефрактерным течением патологического процесса, особенно при наличии в\nанамнезе двустороннего гнойного отита, перенесенного пациенткой, и инфильтрата в легких, расцененного, несмотря на биопсию\nпри первом анализе, как проявление нетипично протекающей пневмонии, уже должно было насторожить врачей в отношении\nдиагноза ГВ. К сожалению, только выраженная дисфагия побудила экстренно госпитализировать пациентку, максимально до-\nобследовать ее с повторным пересмотром ранее взятого биопсийного материала легких и принять правильное решение в пользу\nдиагноза ГВ с назначением последующего адекватного лечения."],"dc.description.abstract.ru_RU":["ранулематоз Вегенера (ГВ), или гранулематоз с полиангиитом, представляет собой первичный системный некротизирующий\nваскулит сосудов мелкого и среднего калибра с развитием очагов гранулематозного воспаления. Это тяжелое, прогрессирующее,\nпредположительно аутоиммунное заболевание, ассоциированное с антинейтрофильными цитоплазматическими антителами,\nвыявляется в основном у людей старше 50 лет. При отсутствии своевременного лечения — иммуносупрессивной терапии (стеро-\nиды и цитостатики для подавления активности заболевания, поддержания ремиссии и лечения рецидивов) оно может привести\nк смерти пациента. В клинике ГВ начинается с симптомов, характерных для любой респираторной инфекции, превалирует\nпоражение верхних дыхательных путей (ринит, назофарингит и пр.), глаз, легких (фиброз, плеврит и т. д.) и почек (гломеруло-\nнефрит). Одним из органов, которые довольно часто (примерно у половины пациентов) поражаются при данном заболевании,\nпричем в основном уже на ранних стадиях, является глаз. С его поражения в ряде случаев может даже начинаться ГВ, но все же\nзначительно чаще орган зрения бывает задействован на фоне развития и длительного течения воспалительного процесса верхних\nдыхательных путей и/или впервые развившегося гнойного воспаления среднего уха у взрослых пациентов, носовых пазух. При ГВ\nможет поражаться любой отдел глаза, чаще всего передний (чаще всего склерит, кератит, реже — язва роговицы и пр.) и зна-\nчительно реже — задний, причем как в виде незначительного воспаления оболочек глаза, так и тяжелого вовлечения всех его\nструктур и орбиты (псевдотумор) с возникновением слабовидения и даже полной слепоты. Трудности в диагностике ГВ обычно\nвозникают из-за разнообразия форм и вариантов клинического течения на ранних стадиях заболевания, когда офтальмологиче-\nские изменения еще малоспецифичны, а системные практически отсутствуют. Приведенный клинический случай ГВ у 62-летней\nпациентки показывает, что диагностика данного заболевания происходит далеко не просто и занимает весьма длительный пе-\nриод времени. Хотя наличие эписклерита/склерита с рефрактерным течением патологического процесса, особенно при наличии в\nанамнезе двустороннего гнойного отита, перенесенного пациенткой, и инфильтрата в легких, расцененного, несмотря на биопсию\nпри первом анализе, как проявление нетипично протекающей пневмонии, уже должно было насторожить врачей в отношении\nдиагноза ГВ. К сожалению, только выраженная дисфагия побудила экстренно госпитализировать пациентку, максимально до-\nобследовать ее с повторным пересмотром ранее взятого биопсийного материала легких и принять правильное решение в пользу\nдиагноза ГВ с назначением последующего адекватного лечения."],"dc.doi":["10.21516/2072-0076-2025-18-1-114-120"],"dc.doi.en":["10.21516/2072-0076-2025-18-1-114-120"],"dc.identifier.issn":["2072-0076"],"dc.identifier.uri":["http://hdl.handle.net/123456789/8786"],"dc.publisher":["Real Time LLC"],"dc.publisher.en":["Real Time LLC"],"dc.relation.ispartofseries":["Rossiiskii Oftal'mologicheskii Zhurnal;т. 18 № 1"],"dc.relation.ispartofseries.en":["Rossiiskii Oftal'mologicheskii Zhurnal;т. 18 № 1"],"subject":["гранулематоз Вегенера","гранулематоз с полиангиитом","некротизирующий васкулит","клинический случай","склерит","язва роговицы","clinical case","corneal ulcer","granulomatosis with polyangiitis","necrotizing vasculitis","scleritis","Wegener’s granulomatosis","Scopus"],"subject_keyword":["гранулематоз Вегенера","гранулематоз Вегенера","гранулематоз с полиангиитом","гранулематоз с полиангиитом","некротизирующий васкулит","некротизирующий васкулит","клинический случай","клинический случай","склерит","склерит","язва роговицы","язва роговицы","clinical case","clinical case","corneal ulcer","corneal ulcer","granulomatosis with polyangiitis","granulomatosis with polyangiitis","necrotizing vasculitis","necrotizing vasculitis","scleritis","scleritis","Wegener’s granulomatosis","Wegener’s granulomatosis","Scopus","Scopus"],"subject_ac":["гранулематоз вегенера\n|||\nгранулематоз Вегенера","гранулематоз с полиангиитом\n|||\nгранулематоз с полиангиитом","некротизирующий васкулит\n|||\nнекротизирующий васкулит","клинический случай\n|||\nклинический случай","склерит\n|||\nсклерит","язва роговицы\n|||\nязва роговицы","clinical case\n|||\nclinical case","corneal ulcer\n|||\ncorneal ulcer","granulomatosis with polyangiitis\n|||\ngranulomatosis with polyangiitis","necrotizing vasculitis\n|||\nnecrotizing vasculitis","scleritis\n|||\nscleritis","wegener’s granulomatosis\n|||\nWegener’s granulomatosis","scopus\n|||\nScopus"],"subject_tax_0_filter":["гранулематоз вегенера\n|||\nгранулематоз Вегенера","гранулематоз с полиангиитом\n|||\nгранулематоз с полиангиитом","некротизирующий васкулит\n|||\nнекротизирующий васкулит","клинический случай\n|||\nклинический случай","склерит\n|||\nсклерит","язва роговицы\n|||\nязва роговицы","clinical case\n|||\nclinical case","corneal ulcer\n|||\ncorneal ulcer","granulomatosis with polyangiitis\n|||\ngranulomatosis with polyangiitis","necrotizing vasculitis\n|||\nnecrotizing vasculitis","scleritis\n|||\nscleritis","wegener’s granulomatosis\n|||\nWegener’s granulomatosis","scopus\n|||\nScopus"],"subject_filter":["гранулематоз вегенера\n|||\nгранулематоз Вегенера","гранулематоз с полиангиитом\n|||\nгранулематоз с полиангиитом","некротизирующий васкулит\n|||\nнекротизирующий васкулит","клинический случай\n|||\nклинический случай","склерит\n|||\nсклерит","язва роговицы\n|||\nязва роговицы","clinical case\n|||\nclinical case","corneal ulcer\n|||\ncorneal ulcer","granulomatosis with polyangiitis\n|||\ngranulomatosis with polyangiitis","necrotizing vasculitis\n|||\nnecrotizing vasculitis","scleritis\n|||\nscleritis","wegener’s granulomatosis\n|||\nWegener’s granulomatosis","scopus\n|||\nScopus"],"dc.subject_mlt":["гранулематоз Вегенера","гранулематоз с полиангиитом","некротизирующий васкулит","клинический случай","склерит","язва роговицы","clinical case","corneal ulcer","granulomatosis with polyangiitis","necrotizing vasculitis","scleritis","Wegener’s granulomatosis","Scopus"],"dc.subject":["гранулематоз Вегенера","гранулематоз с полиангиитом","некротизирующий васкулит","клинический случай","склерит","язва роговицы","clinical case","corneal ulcer","granulomatosis with polyangiitis","necrotizing vasculitis","scleritis","Wegener’s granulomatosis","Scopus"],"dc.subject.ru_RU":["гранулематоз Вегенера","гранулематоз с полиангиитом","некротизирующий васкулит","клинический случай","склерит","язва роговицы"],"dc.subject.en":["clinical case","corneal ulcer","granulomatosis with polyangiitis","necrotizing vasculitis","scleritis","Wegener’s granulomatosis","Scopus"],"title":["Wegener’s granulomatosis in ophthalmic practice. Clinical case","Гранулематоз Вегенера в офтальмологической практике. Клинический случай"],"title_keyword":["Wegener’s granulomatosis in ophthalmic practice. Clinical case","Гранулематоз Вегенера в офтальмологической практике. Клинический случай"],"title_ac":["wegener’s granulomatosis in ophthalmic practice. clinical case\n|||\nWegener’s granulomatosis in ophthalmic practice. Clinical case","гранулематоз вегенера в офтальмологической практике. клинический случай\n|||\nГранулематоз Вегенера в офтальмологической практике. Клинический случай"],"dc.title_sort":"Wegener’s granulomatosis in ophthalmic practice. Clinical case","dc.title_hl":["Wegener’s granulomatosis in ophthalmic practice. Clinical case","Гранулематоз Вегенера в офтальмологической практике. Клинический случай"],"dc.title_mlt":["Wegener’s granulomatosis in ophthalmic practice. Clinical case","Гранулематоз Вегенера в офтальмологической практике. Клинический случай"],"dc.title":["Wegener’s granulomatosis in ophthalmic practice. 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This involves analyzing biomarkers in retinal images, which can be challenging when handling a large flow of patients and can compromise the quality of healthcare services. Clinical decision support systems offer a solution to this issue by employing intelligent algorithms to recognize biomarkers and specify the age-related macular degeneration stage through the analysis of retinal images. However, different stages of age-related macular degeneration may exhibit similar biomarkers, complicating the application of intelligent algorithms. This article presents a hybrid and hierarchical classification method for solving these problems. By leveraging the hybrid structure of the classifier, we can effectively manage issues commonly encountered with medical datasets, such as class imbalance and strong correlations between variables. The modifications to the intelligent algorithm proposed in this work for staging age-related macular degeneration resulted in an increase in average accuracy, sensitivity, and specificity of 20% compared to initial values. The Cohen’s Kappa coefficient, used for consistency estimation between the regression model and expert assessments of the intermediate class severity, was 0.708, indicating a high level of agreement. © 2025 by the authors."],"dc.description.abstract":["Treatment efficacy for age-related macular degeneration relies on early diagnosis and precise determination of the disease stage. This involves analyzing biomarkers in retinal images, which can be challenging when handling a large flow of patients and can compromise the quality of healthcare services. Clinical decision support systems offer a solution to this issue by employing intelligent algorithms to recognize biomarkers and specify the age-related macular degeneration stage through the analysis of retinal images. However, different stages of age-related macular degeneration may exhibit similar biomarkers, complicating the application of intelligent algorithms. This article presents a hybrid and hierarchical classification method for solving these problems. By leveraging the hybrid structure of the classifier, we can effectively manage issues commonly encountered with medical datasets, such as class imbalance and strong correlations between variables. The modifications to the intelligent algorithm proposed in this work for staging age-related macular degeneration resulted in an increase in average accuracy, sensitivity, and specificity of 20% compared to initial values. The Cohen’s Kappa coefficient, used for consistency estimation between the regression model and expert assessments of the intermediate class severity, was 0.708, indicating a high level of agreement. © 2025 by the authors."],"dc.description.abstract.en":["Treatment efficacy for age-related macular degeneration relies on early diagnosis and precise determination of the disease stage. This involves analyzing biomarkers in retinal images, which can be challenging when handling a large flow of patients and can compromise the quality of healthcare services. Clinical decision support systems offer a solution to this issue by employing intelligent algorithms to recognize biomarkers and specify the age-related macular degeneration stage through the analysis of retinal images. However, different stages of age-related macular degeneration may exhibit similar biomarkers, complicating the application of intelligent algorithms. This article presents a hybrid and hierarchical classification method for solving these problems. By leveraging the hybrid structure of the classifier, we can effectively manage issues commonly encountered with medical datasets, such as class imbalance and strong correlations between variables. The modifications to the intelligent algorithm proposed in this work for staging age-related macular degeneration resulted in an increase in average accuracy, sensitivity, and specificity of 20% compared to initial values. The Cohen’s Kappa coefficient, used for consistency estimation between the regression model and expert assessments of the intermediate class severity, was 0.708, indicating a high level of agreement. © 2025 by the authors."],"dc.doi":["10.3390/app15041945"],"dc.identifier.issn":["2076-3417"],"dc.identifier.uri":["http://hdl.handle.net/123456789/8826"],"dc.language.iso":["en"],"dc.language.iso.en":["en"],"dc.publisher":["Multidisciplinary Digital Publishing Institute (MDPI)"],"dc.publisher.en":["Multidisciplinary Digital Publishing Institute (MDPI)"],"dc.relation.ispartofseries":["Applied Sciences (Switzerland);v. 15 №4"],"dc.relation.ispartofseries.en":["Applied Sciences (Switzerland);v. 15 №4"],"subject":["age-related macular degeneration","computer vision","deep learning","hierarchical classification","optical coherence tomography","semi-supervised learning","staging","Scopus"],"subject_keyword":["age-related macular degeneration","age-related macular degeneration","computer 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anna\n|||\nKazakova, Anna","rakina, militsa\n|||\nRakina, Militsa","menyalo, maxim\n|||\nMenyalo, Maxim","enikeeva, kadriia\n|||\nEnikeeva, Kadriia","rafikova, guzel\n|||\nRafikova, Guzel","sharifyanova, yuliya\n|||\nSharifyanova, Yuliya","pavlov, valentin\n|||\nPavlov, Valentin","villert, alisa\n|||\nVillert, Alisa","kolomiets, larisa\n|||\nKolomiets, Larisa","kzhyshkowska, julia\n|||\nKzhyshkowska, Julia"],"dc.contributor.author_hl":["Larionova, Irina","Iamshchikov, Pavel","Kazakova, Anna","Rakina, Militsa","Menyalo, Maxim","Enikeeva, Kadriia","Rafikova, Guzel","Sharifyanova, Yuliya","Pavlov, Valentin","Villert, Alisa","Kolomiets, Larisa","Kzhyshkowska, Julia"],"dc.contributor.author_mlt":["Larionova, Irina","Iamshchikov, Pavel","Kazakova, Anna","Rakina, Militsa","Menyalo, Maxim","Enikeeva, Kadriia","Rafikova, Guzel","Sharifyanova, Yuliya","Pavlov, Valentin","Villert, Alisa","Kolomiets, Larisa","Kzhyshkowska, Julia"],"dc.contributor.author":["Larionova, Irina","Iamshchikov, Pavel","Kazakova, Anna","Rakina, Militsa","Menyalo, Maxim","Enikeeva, Kadriia","Rafikova, Guzel","Sharifyanova, Yuliya","Pavlov, Valentin","Villert, Alisa","Kolomiets, Larisa","Kzhyshkowska, Julia"],"dc.contributor.author_stored":["Larionova, Irina\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Iamshchikov, Pavel\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Kazakova, Anna\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Rakina, Militsa\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Menyalo, Maxim\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Enikeeva, Kadriia\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Rafikova, Guzel\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Sharifyanova, Yuliya\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Pavlov, Valentin\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Villert, Alisa\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Kolomiets, Larisa\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen","Kzhyshkowska, Julia\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen"],"dc.contributor.author.en":["Larionova, Irina","Iamshchikov, Pavel","Kazakova, Anna","Rakina, Militsa","Menyalo, Maxim","Enikeeva, Kadriia","Rafikova, Guzel","Sharifyanova, Yuliya","Pavlov, Valentin","Villert, Alisa","Kolomiets, Larisa","Kzhyshkowska, Julia"],"dc.date.accessioned_dt":"2025-05-07T11:01:55Z","dc.date.accessioned":["2025-05-07T11:01:55Z"],"dc.date.available":["2025-05-07T11:01:55Z"],"dateIssued":["2025-01-01"],"dateIssued_keyword":["2025-01-01","2025"],"dateIssued_ac":["2025-01-01\n|||\n2025-01-01","2025"],"dateIssued.year":[2025],"dateIssued.year_sort":"2025","dc.date.issued_dt":"2025-01-01T00:00:00Z","dc.date.issued":["2025-01-01"],"dc.date.issued_stored":["2025-01-01\n|||\nnull\n|||\nnull\n|||\nnull\n|||\n"],"dc.description.abstract_hl":["Ovarian cancer (OC) is the most lethal gynecologic malignancy worldwide. The major clinical challenge includes the asymptomatic state of the disease, making diagnosis possible only at advanced stages. Another OC complication is the high relapse rate and poor prognosis following the standard first-line treatment with platinum-based chemotherapy. At present, numerous clinical trials are being conducted focusing on immunotherapy in OC; nevertheless, there are still no FDA-approved indications. Personalized decision regarding the immunotherapy, including immune checkpoint blockade and immune cell–based immunotherapies, can depend on the effective antigen presentation required for the cytotoxic immune response. The major aim of our study was to uncover tumor-specific transcriptional and epigenetic changes in peripheral blood monocytes in patients with high-grade serous ovarian cancer (HGSOC). Another key point was to elucidate how chemotherapy can reprogram monocytes and how that relates to changes in other immune subpopulations in the blood. To this end, we performed single-cell RNA sequencing of peripheral blood mononuclear cells (PBMCs) from patients with HGSOC who underwent neoadjuvant chemotherapeutic treatment (NACT) and in treatment-naïve patients. Monocyte cluster was significantly affected by tumor-derived factors as well as by chemotherapeutic treatment. Bioinformatical analysis revealed three distinct monocyte subpopulations within PBMCs based on feature gene expression – CD14.Mn.S100A8.9hi, CD14.Mn.MHC2hi and CD16.Mn subsets. The intriguing result was that NACT induced antigen presentation in monocytes by the transcriptional upregulation of MHC class II molecules, but not by epigenetic changes. Increased MHC class II gene expression was a feature observed across all three monocyte subpopulations after chemotherapy. Our data also demonstrated that chemotherapy inhibited interferon-dependent signaling pathways, but activated some TGFb-related genes. Our results can enable personalized decision regarding the necessity to systemically re-educate immune cells to prime ovarian cancer to respond to anti-cancer therapy or to improve personalized prescription of existing immunotherapy in either combination with chemotherapy or a monotherapy regimen. Copyright © 2024 Larionova, Iamshchikov, Kazakova, Rakina, Menyalo, Enikeeva, Rafikova, Sharifyanova, Pavlov, Villert, Kolomiets and Kzhyshkowska."],"dc.description.abstract":["Ovarian cancer (OC) is the most lethal gynecologic malignancy worldwide. The major clinical challenge includes the asymptomatic state of the disease, making diagnosis possible only at advanced stages. Another OC complication is the high relapse rate and poor prognosis following the standard first-line treatment with platinum-based chemotherapy. At present, numerous clinical trials are being conducted focusing on immunotherapy in OC; nevertheless, there are still no FDA-approved indications. Personalized decision regarding the immunotherapy, including immune checkpoint blockade and immune cell–based immunotherapies, can depend on the effective antigen presentation required for the cytotoxic immune response. The major aim of our study was to uncover tumor-specific transcriptional and epigenetic changes in peripheral blood monocytes in patients with high-grade serous ovarian cancer (HGSOC). Another key point was to elucidate how chemotherapy can reprogram monocytes and how that relates to changes in other immune subpopulations in the blood. To this end, we performed single-cell RNA sequencing of peripheral blood mononuclear cells (PBMCs) from patients with HGSOC who underwent neoadjuvant chemotherapeutic treatment (NACT) and in treatment-naïve patients. Monocyte cluster was significantly affected by tumor-derived factors as well as by chemotherapeutic treatment. Bioinformatical analysis revealed three distinct monocyte subpopulations within PBMCs based on feature gene expression – CD14.Mn.S100A8.9hi, CD14.Mn.MHC2hi and CD16.Mn subsets. The intriguing result was that NACT induced antigen presentation in monocytes by the transcriptional upregulation of MHC class II molecules, but not by epigenetic changes. Increased MHC class II gene expression was a feature observed across all three monocyte subpopulations after chemotherapy. Our data also demonstrated that chemotherapy inhibited interferon-dependent signaling pathways, but activated some TGFb-related genes. Our results can enable personalized decision regarding the necessity to systemically re-educate immune cells to prime ovarian cancer to respond to anti-cancer therapy or to improve personalized prescription of existing immunotherapy in either combination with chemotherapy or a monotherapy regimen. Copyright © 2024 Larionova, Iamshchikov, Kazakova, Rakina, Menyalo, Enikeeva, Rafikova, Sharifyanova, Pavlov, Villert, Kolomiets and Kzhyshkowska."],"dc.description.abstract.en":["Ovarian cancer (OC) is the most lethal gynecologic malignancy worldwide. The major clinical challenge includes the asymptomatic state of the disease, making diagnosis possible only at advanced stages. Another OC complication is the high relapse rate and poor prognosis following the standard first-line treatment with platinum-based chemotherapy. At present, numerous clinical trials are being conducted focusing on immunotherapy in OC; nevertheless, there are still no FDA-approved indications. Personalized decision regarding the immunotherapy, including immune checkpoint blockade and immune cell–based immunotherapies, can depend on the effective antigen presentation required for the cytotoxic immune response. The major aim of our study was to uncover tumor-specific transcriptional and epigenetic changes in peripheral blood monocytes in patients with high-grade serous ovarian cancer (HGSOC). Another key point was to elucidate how chemotherapy can reprogram monocytes and how that relates to changes in other immune subpopulations in the blood. To this end, we performed single-cell RNA sequencing of peripheral blood mononuclear cells (PBMCs) from patients with HGSOC who underwent neoadjuvant chemotherapeutic treatment (NACT) and in treatment-naïve patients. Monocyte cluster was significantly affected by tumor-derived factors as well as by chemotherapeutic treatment. Bioinformatical analysis revealed three distinct monocyte subpopulations within PBMCs based on feature gene expression – CD14.Mn.S100A8.9hi, CD14.Mn.MHC2hi and CD16.Mn subsets. The intriguing result was that NACT induced antigen presentation in monocytes by the transcriptional upregulation of MHC class II molecules, but not by epigenetic changes. Increased MHC class II gene expression was a feature observed across all three monocyte subpopulations after chemotherapy. Our data also demonstrated that chemotherapy inhibited interferon-dependent signaling pathways, but activated some TGFb-related genes. Our results can enable personalized decision regarding the necessity to systemically re-educate immune cells to prime ovarian cancer to respond to anti-cancer therapy or to improve personalized prescription of existing immunotherapy in either combination with chemotherapy or a monotherapy regimen. Copyright © 2024 Larionova, Iamshchikov, Kazakova, Rakina, Menyalo, Enikeeva, Rafikova, Sharifyanova, Pavlov, Villert, Kolomiets and Kzhyshkowska."],"dc.doi":["10.3389/fimmu.2024.1414716"],"dc.doi.en":["10.3389/fimmu.2024.1414716"],"dc.identifier.issn":["1664-3224"],"dc.identifier.uri":["http://hdl.handle.net/123456789/8832"],"dc.language.iso":["en"],"dc.language.iso.en":["en"],"dc.publisher":["Frontiers Media SA"],"dc.publisher.en":["Frontiers Media SA"],"dc.relation.ispartofseries":["Frontiers in Immunology;v. 15"],"dc.relation.ispartofseries.en":["Frontiers in Immunology;v. 15"],"subject":["antigen presentation","chemotherapy","methylation","monocyte","ovarian cancer","single cell sequencing","transcriptome","Scopus"],"subject_keyword":["antigen presentation","antigen presentation","chemotherapy","chemotherapy","methylation","methylation","monocyte","monocyte","ovarian cancer","ovarian cancer","single cell sequencing","single cell sequencing","transcriptome","transcriptome","Scopus","Scopus"],"subject_ac":["antigen presentation\n|||\nantigen presentation","chemotherapy\n|||\nchemotherapy","methylation\n|||\nmethylation","monocyte\n|||\nmonocyte","ovarian cancer\n|||\novarian cancer","single cell sequencing\n|||\nsingle cell sequencing","transcriptome\n|||\ntranscriptome","scopus\n|||\nScopus"],"subject_tax_0_filter":["antigen presentation\n|||\nantigen presentation","chemotherapy\n|||\nchemotherapy","methylation\n|||\nmethylation","monocyte\n|||\nmonocyte","ovarian cancer\n|||\novarian cancer","single cell sequencing\n|||\nsingle cell sequencing","transcriptome\n|||\ntranscriptome","scopus\n|||\nScopus"],"subject_filter":["antigen presentation\n|||\nantigen presentation","chemotherapy\n|||\nchemotherapy","methylation\n|||\nmethylation","monocyte\n|||\nmonocyte","ovarian cancer\n|||\novarian cancer","single cell sequencing\n|||\nsingle cell sequencing","transcriptome\n|||\ntranscriptome","scopus\n|||\nScopus"],"dc.subject_mlt":["antigen presentation","chemotherapy","methylation","monocyte","ovarian cancer","single cell sequencing","transcriptome","Scopus"],"dc.subject":["antigen presentation","chemotherapy","methylation","monocyte","ovarian cancer","single cell sequencing","transcriptome","Scopus"],"dc.subject.en":["antigen presentation","chemotherapy","methylation","monocyte","ovarian cancer","single cell sequencing","transcriptome","Scopus"],"title":["Platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma"],"title_keyword":["Platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma"],"title_ac":["platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma\n|||\nPlatinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma"],"dc.title_sort":"Platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma","dc.title_hl":["Platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma"],"dc.title_mlt":["Platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma"],"dc.title":["Platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma"],"dc.title_stored":["Platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma\n|||\nnull\n|||\nnull\n|||\nnull\n|||\nen"],"dc.title.en":["Platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma"],"dc.title.alternative":["Platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma"],"dc.title.alternative.en":["Platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma"],"dc.type":["Article"],"dc.type.en":["Article"],"publication_grp":["123456789/8832"],"bi_2_dis_filter":["kazakova, anna\n|||\nKazakova, Anna","rakina, militsa\n|||\nRakina, Militsa","enikeeva, kadriia\n|||\nEnikeeva, Kadriia","larionova, irina\n|||\nLarionova, Irina","rafikova, guzel\n|||\nRafikova, Guzel","kzhyshkowska, julia\n|||\nKzhyshkowska, Julia","kolomiets, larisa\n|||\nKolomiets, Larisa","menyalo, maxim\n|||\nMenyalo, Maxim","sharifyanova, yuliya\n|||\nSharifyanova, Yuliya","pavlov, valentin\n|||\nPavlov, Valentin","villert, alisa\n|||\nVillert, Alisa","iamshchikov, pavel\n|||\nIamshchikov, Pavel"],"bi_2_dis_partial":["Menyalo, Maxim","Kolomiets, Larisa","Kzhyshkowska, Julia","Enikeeva, Kadriia","Rafikova, Guzel","Rakina, Militsa","Sharifyanova, Yuliya","Pavlov, Valentin","Larionova, Irina","Iamshchikov, Pavel","Kazakova, Anna","Villert, Alisa"],"bi_2_dis_value_filter":["Menyalo, Maxim","Kolomiets, Larisa","Kzhyshkowska, Julia","Enikeeva, Kadriia","Rafikova, Guzel","Rakina, Militsa","Sharifyanova, Yuliya","Pavlov, Valentin","Larionova, Irina","Iamshchikov, Pavel","Kazakova, Anna","Villert, Alisa"],"bi_4_dis_filter":["ovarian cancer\n|||\novarian cancer","transcriptome\n|||\ntranscriptome","chemotherapy\n|||\nchemotherapy","antigen presentation\n|||\nantigen presentation","methylation\n|||\nmethylation","single cell sequencing\n|||\nsingle cell sequencing","scopus\n|||\nScopus","monocyte\n|||\nmonocyte"],"bi_4_dis_partial":["antigen presentation","ovarian cancer","methylation","transcriptome","Scopus","monocyte","single cell 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1"],"dc.title_mlt":["REGIONAL LIVING CONDITIONS AND CIRCULATORY DISEASE RATES IN THE RUSSIAN WORKING-AGE POPULATION"],"bi_4_dis_partial":["Circulatory diseases"],"dc.subject.en":["Circulatory diseases"],"dc.title.alternative.en":["REGIONAL LIVING CONDITIONS AND CIRCULATORY DISEASE RATES IN THE RUSSIAN WORKING-AGE POPULATION"],"title":["REGIONAL LIVING CONDITIONS AND CIRCULATORY DISEASE RATES IN THE RUSSIAN WORKING-AGE POPULATION"],"dc.relation.ispartofseries.en":["Complex Issues of Cardiovascular Diseases;т. 14 № 1"],"dc.subject":["Circulatory diseases"],"dc.subject_mlt":["Circulatory diseases"],"dc.abstract.en":[" incidence and prevalence rates of circulatory system diseases in the population based on official statistics"],"subject":["Circulatory diseases"],"dc.title.alternative":["REGIONAL LIVING CONDITIONS AND CIRCULATORY DISEASE RATES IN THE RUSSIAN WORKING-AGE POPULATION"],"dc.abstract":[" incidence and prevalence rates of circulatory system diseases in the population based on official statistics"]},"2-7741":{"dc.title.en":["The functions of immune system-derived miRNAs in cardiovascular diseases"],"dc.description.abstract":["Cardiovascular diseases (CVD) are the foremost cause of mortality worldwide, with recent advances"],"dc.title":["The functions of immune system-derived miRNAs in cardiovascular diseases"],"dc.title_hl":["The functions of immune system-derived miRNAs in cardiovascular diseases"],"dc.title_mlt":["The functions of immune system-derived miRNAs in cardiovascular diseases"],"bi_4_dis_partial":["Immune system cells"],"dc.description.abstract.en":["Cardiovascular diseases (CVD) are the foremost cause of mortality worldwide, with recent advances"],"dc.subject.en":["Cardiovascular diseases"],"dc.title.alternative.en":["The functions of immune system-derived miRNAs in cardiovascular diseases"],"title":["The functions of immune system-derived miRNAs in cardiovascular diseases"],"dc.description.abstract_hl":["Cardiovascular diseases (CVD) are the foremost cause of mortality worldwide, with recent advances"],"dc.subject":["Cardiovascular diseases"],"dc.subject_mlt":["Cardiovascular diseases"],"subject":["Cardiovascular diseases"],"dc.title.alternative":["The functions of immune system-derived miRNAs in cardiovascular diseases"]},"2-7898":{"dc.title.en":["Analysis of systemic risk factors in young patients with retinal vein occlusion"],"dc.title":["Analysis of systemic risk factors in young patients with retinal vein occlusion"],"dc.title_hl":["Analysis of systemic risk factors in young patients with retinal vein occlusion"],"dc.title_mlt":["Analysis of systemic risk factors in young patients with retinal vein occlusion"],"dc.title.alternative.en":["Analysis of systemic risk factors in young patients with retinal vein occlusion"],"title":["Analysis of systemic risk factors in young patients with retinal vein occlusion"],"dc.abstract.en":["Purpose: to analyze systemic risk factors of retinal vein occlusion (RVO) in young patients"],"dc.title.alternative":["Analysis of systemic risk factors in young patients with retinal vein occlusion"],"dc.abstract":["Purpose: to analyze systemic risk factors of retinal vein occlusion (RVO) in young patients"]},"2-7926":{"dc.description.abstract":[" of the disease is associated with an impact on genes and signaling pathways regulating cell proliferation"],"bi_4_dis_partial":["immune system"],"dc.description.abstract.en":[" of the disease is associated with an impact on genes and signaling pathways regulating cell proliferation"],"dc.subject.en":["immune system"],"dc.description.abstract_hl":[" of the disease is associated with an impact on genes and signaling pathways regulating cell proliferation"],"dc.subject":["immune system"],"dc.subject_mlt":["immune system"],"subject":["immune system"]},"2-7808":{"dc.title.en":["Mortality and ocular parameters and diseases"],"dc.description.abstract":["Background: To assess associations between mortality and major ocular parameters and diseases"],"dc.title":["Mortality and ocular parameters and diseases"],"dc.title_hl":["Mortality and ocular parameters and diseases"],"dc.title_mlt":["Mortality and ocular parameters and diseases"],"dc.description.abstract.en":["Background: To assess associations between mortality and major ocular parameters and diseases"],"dc.title.alternative.en":["Mortality and ocular parameters and diseases"],"title":["Mortality and ocular parameters and diseases"],"dc.description.abstract_hl":["Background: To assess associations between mortality and major ocular parameters and diseases"],"dc.title.alternative":["Mortality and ocular parameters and diseases"]},"2-7889":{"dc.title.en":["The role of oral microbiota in the etiology, pathogenesis of periodontitis and systemic pathology"],"dc.title":["The role of oral microbiota in the etiology, pathogenesis of periodontitis and systemic pathology"],"dc.title_hl":["The role of oral microbiota in the etiology, pathogenesis of periodontitis and systemic pathology"],"dc.title_mlt":["The role of oral microbiota in the etiology, pathogenesis of periodontitis and systemic pathology"],"dc.title.alternative.en":["The role of oral microbiota in the etiology, pathogenesis of periodontitis and systemic pathology"],"title":["The role of oral microbiota in the etiology, pathogenesis of periodontitis and systemic pathology"],"dc.abstract.en":[" in the etiology and pathogenesis of periodontitis as a widespread disease that negatively affects the quality"],"dc.title.alternative":["The role of oral microbiota in the etiology, pathogenesis of periodontitis and systemic pathology"],"dc.abstract":[" in the etiology and pathogenesis of periodontitis as a widespread disease that negatively affects the quality"]},"2-8043":{"dc.title.en":["Systemic Benign Lipomatosis (Madelung’s Disease): Experience of Surgical Treatment. Clinical Case"],"dc.title":["Systemic Benign Lipomatosis (Madelung’s Disease): Experience of Surgical Treatment. Clinical Case"],"dc.title_hl":["Systemic Benign Lipomatosis (Madelung’s Disease): Experience of Surgical Treatment. Clinical Case"],"dc.title_mlt":["Systemic Benign Lipomatosis (Madelung’s Disease): Experience of Surgical Treatment. Clinical Case"],"bi_4_dis_partial":["Madelung’s disease"],"dc.subject.en":["Madelung’s disease"],"title":["Systemic Benign Lipomatosis (Madelung’s Disease): Experience of Surgical Treatment. Clinical Case"],"dc.citation.en":["Liu Q., Lyu H., Xu B., Lee J.H. Madelung disease epidemiology and clinical characteristics: a"],"dc.subject":["Madelung’s disease"],"dc.citation.ru":["Liu Q., Lyu H., Xu B., Lee J.H. Madelung disease epidemiology and clinical characteristics: a"],"dc.subject_mlt":["Madelung’s disease"],"dc.abstract.en":["

Introduction. Diffuse symmetric lipomatosis (Madelung’s disease) is a rare"],"dc.citation":["Liu Q., Lyu H., Xu B., Lee J.H. Madelung disease epidemiology and clinical characteristics: a"],"subject":["Madelung’s disease"],"dc.abstract":["

Introduction. Diffuse symmetric lipomatosis (Madelung’s disease) is a rare"]},"2-7897":{"dc.abstract.en":["Wegener’s granulomatosis (WG) or granulomatosis with polyangiitis is a primary systemic necrotizing"],"dc.abstract":["Wegener’s granulomatosis (WG) or granulomatosis with polyangiitis is a primary systemic necrotizing"]},"2-7937":{"dc.description.abstract":[" determination of the disease stage. This involves analyzing biomarkers in retinal images, which can"],"dc.description.abstract.en":[" determination of the disease stage. This involves analyzing biomarkers in retinal images, which can"],"dc.description.abstract_hl":[" determination of the disease stage. This involves analyzing biomarkers in retinal images, which can"]},"2-7943":{"dc.description.abstract":[" challenge includes the asymptomatic state of the disease, making diagnosis possible only at advanced stages"],"dc.description.abstract.en":[" challenge includes the asymptomatic state of the disease, making diagnosis possible only at advanced stages"],"dc.description.abstract_hl":[" challenge includes the asymptomatic state of the disease, making diagnosis possible only at advanced stages"]}}} -->