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ПОЛИМОРФНЫЕ ВАРИАНТЫ ГЕНОВ ГЛУТАМАТНЫХ (GRIK5, GRIN2B) И СЕРОТОНИНОВОГО (HTR2A) РЕЦЕПТОРОВ АССОЦИИРОВАНЫ С ХРОНИЧЕСКОЙ ОБСТРУКТИВНОЙ БОЛЕЗНЬЮ ЛЕГКИХ. Smoking index (pack-years) was significantly higher in carriers of the GRIK5 genotype AC (rs8099939) (P

in nonsmokers. Lower smoking index were observed in carriers of the GRIK3 (rs534131) genotype GG and GRIA1 (rs

COPD risk predictive model, which included gene–gene combinations of lncRNAs genes and smoking index (P

Взаимосвязь между полиморфизмами генов хемокинов и хемокиновых рецепторов и восприимчивостью к хронической обструктивной болезни легких у татарского населения из России: исследование случай-контроль

ASSOCIATIONS OF THE NRF2/KEAP1 PATHWAY AND ANTIOXIDANT DEFENSE GENE POLYMORPHISMS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE and smoking pack-years. The results: In our population, a significant associations of KEAP1 (rs1048290) (P = 0

analyses were performed to estimate the relationship between SNPs and lung function parameters and smoking

-by-environment interaction of smoking status and IL17A (rs1974226) (P interact = 0.016), JAK3 (rs3212780) (P interact = 0

); this association was confirmed in the subgroups differentiated by smoking status. Markers of COPD risk were also

with age and smoking pack/years, indicating a high ability of the model to correctly classify individuals

МОЛЕКУЛЯРНЫЕ МЕХАНИЗМЫ ФЕНОТИПИЧЕСКОЙ ГЕТЕРОГЕННОСТИ ХРОНИЧЕСКОЙ ОБСТРУКТИВНОЙ БОЛЕЗНИ ЛЕГКИХ: РОЛЬ JAK/STAT-, NFKB1- СИГНАЛЬНОГО ПУТИ И МОЛЕКУЛ ИММУННОГО ОТВЕТА

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