Статья
Synthesis and Antiaggregant Activity of 2-[3-Methyl-1-Ethylxanthinyl-8-Thio]Acetic Acid Salts Containing a Thietane Ring
2018
Reaction of 7-(thietanyl-3)-, 7-(1-oxothietanyl-3)-, and 7-(1,1-dioxothietanyl-3)-8-bromo-3-methyl-1-ethylxanthines with thioglycolic acid produced 2-[3-methyl-1-ethylxanthinyl-8-thio]acetic acids containing a thietane ring with yields of 76 - 93%. Interaction of these acids with bases (sodium hydroxide, morpholine, hexamethyleneimine) produced 2-[3-methyl-1-ethylxanthinyl-8-thio]acetic acid salts containing a thietane ring, with yields of 44 - 96%. The structures of these compounds were confirmed by IR and NMR spectroscopy data. The compounds synthesized here had potentially high antiaggregatory activity.
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