RT - Article
SR - Electronic
T1 - 
SP - 2020-12-16
DO - 10.1007/s11094-018-1764-y
A1 - , 
A1 - , 
A1 - , 
A1 - , 
A1 - , 
A1 - , 
YR - 2018
UL - https://repo.bashgmu.ru/publication/1133
AB - Reaction of 7-(thietanyl-3)-, 7-(1-oxothietanyl-3)-, and 7-(1,1-dioxothietanyl-3)-8-bromo-3-methyl-1-ethylxanthines with thioglycolic acid produced 2-[3-methyl-1-ethylxanthinyl-8-thio]acetic acids containing a thietane ring with yields of 76 - 93%. Interaction of these acids with bases (sodium hydroxide, morpholine, hexamethyleneimine) produced 2-[3-methyl-1-ethylxanthinyl-8-thio]acetic acid salts containing a thietane ring, with yields of 44 - 96%. The structures of these compounds were confirmed by IR and NMR spectroscopy data. The compounds synthesized here had potentially high antiaggregatory activity.