SYNTHESIS AND ANTIOXIDANT ACTIVITY OF QUERCETIN ETHERS
Publication date: 2015
Abstract:
Quercetin (Q) methyl ethers were synthesized from CH3I under various conditions. The principal products from the reactions of Q with alkylhalides (CH3I, C4H9Br) in DMF were 3,7,4′-tri-O-alkyl ethers. The structures of the products were confirmed by PMR and 13C NMR spectra. The antioxidant activity of Q tetra- and tri-O-methyl ethers was demonstrated by chemiluminescence in model systems generating active oxygen species and promoting lipid peroxidation.