Статья
Synthesis and Antiaggregant and Anticoagulant Activity of New 1-(4-Alkyloxybenzyl)-1H-Azoles and 1-(Adamantyl-1)-2-[4-(1H-Azol-1-Ylmethyl)-Phenoxy]Ethanones
2021
The development and optimization of synthetic methods for alkyl esters of 4-[(1H-azol-1-yl)methyl]phenols enabled the expansion of organic synthesis methodology, which is extremely important for designing new structures with various types of biological activity, e.g., antiaggregant and anticoagulant. The present work studied O-alkylation of 4-[(1H-azol-1-yl)methyl]phenols with various alkylating agents, e.g., n-octyl bromide, n-hexadecyl bromide, and (adamantyl-1)bromomethylketone. The newly synthesized compounds were identified using elemental analysis and IR and PMR spectroscopy. Laboratory studies of blood isolated from healthy volunteers revealed compounds with antiaggregant and anticoagulant properties.
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