in the
antidepressant effect of a new 3-substituted thietane-1,1-dioxide derivative (N-199/1) using tests with several
receiving
antidepressant therapy, there is an urgent need for developing novel agents with
antidepressantValeeva, L.A.,
Davlyatova, G.G.,
Shabalina, Yu.V.,
Isakova, A.V.,
Khaliullin, F.A.,
Nikitina, I.L. (2016) -thio]acetic acid hydrazide exhibited
antidepressant activity that was most pronounced at a dose of 12
Klen, E.E.,
Nikitina, I.L.,
Khaliullin, F.A.,
Shepilova, S.O.,
Nikitina, E.A.,
Gaisina, G.G.,
Samorodov, A.V.,
Pavlov, V.N. (2024) , tumorigenicity, reproductive
effects, irritating
effects), low toxicity (class IV-V), and acceptable oral
/kg) exhibited
antidepressant-like
effects at doses equimolar to amitriptyline (10 mg/kg); IId (2 mg/kg) and IIb
-substituted thietane-1,1-dioxide derivative (N-199/1) exhibiting
antidepressant properties, in several tests
. The aim of the study was to evaluate the
antidepressant effect of 3ETD in a model of depressive-like state
A compound with low toxicity and pronounced
antidepressant activity upon single and long