in the
antidepressant effect of a new 3-substituted thietane-1,1-dioxide derivative (N-199/1) using tests with several
)-dione and cyclohexylamine and exhibited
antidepressant activity that was most pronounced at a dose of 1.6 mg/kg.
spectroscopy. The synthesized compounds exhibited
antidepressant activity.
receiving
antidepressant therapy, there is an urgent need for developing novel agents with
antidepressantValeeva, L.A.,
Davlyatova, G.G.,
Shabalina, Yu.V.,
Isakova, A.V.,
Khaliullin, F.A.,
Nikitina, I.L. (2016) -thio]acetic acid hydrazide exhibited
antidepressant activity that was most pronounced at a dose of 12
/kg) exhibited
antidepressant-like effects at doses equimolar to amitriptyline (10 mg/kg); IId (2 mg/kg) and IIb
Khaliullin, F.A.,
Klen, E.E.,
Nikitina, I.L.,
Pavlov, V.N.,
Rozit, G.A.,
Gaisina, G.G.,
Samorodov, A.V. (2023) . An in vivo study of the
antidepressant activity revealed the promising compound 1-(1,1-dioxidothietan-3-yl)-4
Klen, E.E.,
Nikitina, I.L.,
Khaliullin, F.A.,
Shepilova, S.O.,
Nikitina, E.A.,
Gaisina, G.G.,
Samorodov, A.V.,
Pavlov, V.N. (2024) bioavailability. The compounds exhibited varying degrees of
antidepressant activity after a single intraperitoneal