SYNTHESIS AND ANTIDEPRESSANT PROPERTIES OF 3-METHYL-7-(1,1-DIOXOTHIETAN-3-YL)-8-CYCLOHEXYLAMINO-1-ETHYL-1H-PURINE-2,6(3H,7H)-DIONE

Дата публикации: 2018

Аннотация:

3-Methyl-7-(1,1-dioxothietan-3-yl)-8-cyclohexylamino-1-ethyl-1H-purine-2,6(3H,7H)-dione was synthesized via the reaction of 8-bromo-3-methyl-7-(1,1-dioxothietan-3-yl)-1-ethyl-1H-purine-2,6(3H,7H)-dione and cyclohexylamine and exhibited antidepressant activity that was most pronounced at a dose of 1.6 mg/kg. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.

ключевые слова:
antidepressant activity, synthesis, thietanes, xanthines

Издатель: Springer New York LLC

Тип: Article

DOI: 10.1007/s11094-018-1738-0