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cells. In addition, compounds 3a and 3b exhibit platelet antiaggregation activity at the level

in lipopolysaccharide (LPS)-challenged J774A.1 cells. Compounds 19, 20, and 39 potently reduced the release of IL-6

5-АМИНОЗАМЕЩЕННЫЕ ТИЕТАНСОДЕРЖАЩИЕ 3-БРОМ-4-НИТРОПИРАЗОЛЫ С АНТИДЕПРЕССИВНОЙ АКТИВНОСТЬЮ

for the design and production of novel biologically active compounds. In this study, by using the molecular

. It was hypothesized that compounds synthesized from natural amino acids would possess these pharmacological activities

. The structures of the synthesized compounds were confirmed by IR, PMR, and 13C and 15N NMR spectroscopy

. The structures of the synthesized compounds were confirmed by IR, PMR, and 13C and 15N NMR spectroscopy

) compounds

and synthesized using cinnamic acid as the lead compound. We tested the preliminary anti-inflammatory activity

-7 breast adenocarcinoma, and SH-SY5Y neuroblastoma cells was studied. The most active compound

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