Влияние ретроэлементов на онкогены и онкосупрессоры в канцерогенезе клеток. Важно
отметить, что белковые продукты таких ОСГ, как ТР53, RB1, VHL,
BRCA1, ATM, обладают
Роль мутаций в гене NF1 в спорадическом канцерогенезе and specific types of sporadic neoplasms, in which
mutations in NF1 gene are found, are presented. Evidence
mutations in NF1 gene. Protein product of NF1 is a neurofibromin, which inhibits RAS-RAF-MEK-ERK system
by specific
mutations in the NF1 gene (causing substitutions of amino acids in neurofibromin: p.Arg1038, p
Изменения иммунной системы в патогенезе нейрофиброматоза 1-го типа of the population. NF1 is caused by germline heterozygous
mutations in the NF1 gene, which encodes
, the search for
mutations in these genes is promising. Conclusion Most patients with NF1 develop orthopedic
of information. Results and discussion
Mutations in proinflammatory cytokine and receptor genes, metalloprotease