Статья
SYNTHESIS AND BIOLOGICAL ACTIVITY OF CYANOETHYL DERIVATIVES OF FUSIDIC ACID
2018
3,11-Dihydroxy and 3,11-dioxo triterpenoids of the fusidane series reacted with acrylonitrile in 1,4-dioxane in the presence of alkali and phase-transfer catalyst to give mono- and bis(2-cyanoethoxy) and 2-cyanoethyl derivatives. The reaction with 3,11-dioxo analog afforded 2,2-disubstituted derivative as a result of addition of two cyanoethyl groups to the -position with respect to the C-3=O carbonyl group. The isolated compounds were screened for antibacterial and antifungal activities.
Salimova, E.V., Mamaev, A.G., Tret'yakova, E. V., Kukovinets, O. S., Mavzyutov, A. R., Shvets, K. Yu., Parfenova, L. V. . 2018; https://doi.org/10.1134/S1070428018090245
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