Salimova, E.V. Mamaev, A.G. Tret'yakova, E. V. Kukovinets, O. S. Mavzyutov, A. R. Shvets, K. Yu. Parfenova, L. V. 2018

2019-02-08

10.1134/S1070428018090245 3,11-Dihydroxy and 3,11-dioxo triterpenoids of the fusidane series reacted with acrylonitrile in 1,4-dioxane in the presence of alkali and phase-transfer catalyst to give mono- and bis(2-cyanoethoxy) and 2-cyanoethyl derivatives. The reaction with 3,11-dioxo analog afforded 2,2-disubstituted derivative as a result of addition of two cyanoethyl groups to the -position with respect to the C-3=O carbonyl group. The isolated compounds were screened for antibacterial and antifungal activities.

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