Статья

Synthesis and Antitumor Activity of Hybrid Compounds Based on Aryl-Substituted Isatins and 2-Chloroethynyl (4-(Dimetylamino)phenyl)(2-hydrazinyl-2-oxoethyl)phosphinate

Bogdanov, A.V., Ivanova, A.A., Voloshina, A.D., Rakhmatullin, R.R., Samorodov, A.V., Valiullina, Z.A., Krylova, I.D., Bukharov, S.V.
2024
https://doi.org/10.1134/S1070363224080085

New phosphorus-containing isatin-3-hydrazones were synthesized by the condensation reaction of 5-substituted isatins with 2-chloroethyl [4-(dimethylamino)phenyl](2-hydrazinyl-2-oxoethyl)phosphinate (KAPAKh). The resulting compounds were shown to have high antitumor activity against duodenal adenocarcinoma (HuTu80) and cervical epithelioid carcinoma (M-HeLa) cell lines with low toxicity towards erythrocytes and normal human liver cells. © Pleiades Publishing, Ltd. 2024.

. 2024; https://doi.org/10.1134/S1070363224080085
Цитирование

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Документы

Информация

Автор
Рубрика
  • biological activity, hydrazones, isatin, phosphine oxides, phosphorus, Scopus
Год публикации
  • 2024
Издатель
  • Pleiades Publishing
Тип документа
  • Article
Коллекции
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