EXPERIMENTAL ANTIOXIDANT ACTIVITY OF A b-CYCLODEXTRIN – HISTOCHROME COMPLEX

Bikbov, M.M.; Nikitin, N.A.; Surkova, V.K.; Farkhutdinov, R.R.; Khalilov, L.M.; Tulyabaev, A.R.; Nikitina, A.F.; Fedoreev, S.A.; Mishchenko4, N.P.

EXPERIMENTAL ANTIOXIDANT ACTIVITY OF A b-CYCLODEXTRIN – HISTOCHROME COMPLEX

Bikbov, M.M., Nikitin, N.A., Surkova, V.K., Farkhutdinov, R.R., Khalilov, L.M., Tulyabaev, A.R., Nikitina, A.F., Fedoreev, S.A., Mishchenko4, N.P.

Publication date: 2018

DOI: 10.1007/s11094-018-1727-3

Abstract:

A2:1 β-cyclodextrin – histochrome complex was synthesized based on a comparison with experimental studies of histochrome and showed antioxidant activity prolonged to 16 d as compared with 6 d for histochrome in tests of the duration of the in vitro antioxidant effect. PMR measurements proved that a β-cyclodextrin – histochrome complex formed. Computer modeling of the β-cyclodextrin–histochrome complex showed that the head-to-tail complex corresponded to the energy minimum.

Keywords:
histochrome, emoxypine, β-cyclodextrin, antioxidant activity, Scopus, Web of Science

Тип: Article

EXPERIMENTAL ANTIOXIDANT ACTIVITY OF A b-CYCLODEXTRIN – HISTOCHROME COMPLEX

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