Publication date: 2016

DOI: 10.1134/S1022795416020113

Abstract—Peptic ulcer disease is a chronic disease of the gastrointestinal tract, mainly manifesting itself in the formation of the fairly persistent ulcer defect of the mucous membrane of the stomach and/or duodenum. Association analysis of common polymorphisms of matrix metalloproteinases genes MMP1 (rs1799750, rs494379), MMP2 (rs2285052), MMP3 (rs3025058), MMP9 (rs3918242, rs17576), and MMP12 (rs2276109) and their tissue inhibitors TIMP2 (rs8179090) and TIMP3 (rs9619311) was carried out in 353 patients with a gastric ulcer or duodenal ulcer and in 325 unrelated healthy individuals from the Republic of Bashkortostan. Associations of polymorphic variants rs1799750 and rs494379 of gene MMP1, rs3025058 of gene MMP3, rs3918242 and rs17576 of gene MMP9, and rs9619311 of gene TIMP3 with the risk of peptic ulcer disease in Russians and Tatars were revealed.

Тип: Article