SYNTHESIS OF PYRINIDINE-2,4(1H,3H)-DIONE DERIVATIVES CONTAINING N-ALKYL SUBSTITUENTS

Раскильдина, Г.З.; Валиев, В.Ф.; Озден, И.В.; Мещерякова, С.А.; Спирихин, Л.В.; Злоцкий, С.С.; Raskildinaa, G.Z.; Valieva, V.F.; Ozdena, I.V.; Meshcheryakova, S.A.; Spirikhinc, L.V.; Zlotskii, S.S.

SYNTHESIS OF PYRINIDINE-2,4(1H,3H)-DIONE DERIVATIVES CONTAINING N-ALKYL SUBSTITUENTS

Raskildinaa, G.Z., Valieva, V.F., Ozdena, I.V., Meshcheryakova, S.A., Spirikhinc, L.V., Zlotskii, S.S.

Publication date: 2017

Abstract:

Abstract—6-Methyluracil derivatives containing a gem-dichlorocyclopropane and a 1,3-dioxolane fragments were synthesized for the first time. The condensation of 6-methyluracil with chloromethyl derivatives gives a mixture of N1 - and N3 -monosubstituted products, and the profound N-alkylation of this compound provides disubstituted uracils. The structure of the synthesized compounds was studied by H1 and 13С NMR spectroscopy and their relative antioxidant activity was evaluated by luminol-dependent chemiluminescence measurements.

Keywords:
6-methyluracil, N-alkylation, gem-dichlorocyclopropane, 4-(chloromethyl)-1,3-dioxolane, antioxidant properties

Тип: Article

DOI https://doi.org/10.1134/S1070363217080369

SYNTHESIS OF PYRINIDINE-2,4(1H,3H)-DIONE DERIVATIVES CONTAINING N-ALKYL SUBSTITUENTS

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