Abstract—6-Methyluracil derivatives containing a gem-dichlorocyclopropane and a 1,3-dioxolane fragments
were synthesized for the first time. The condensation of 6-methyluracil with chloromethyl derivatives gives a
mixture of N1
- and N3
-monosubstituted products, and the profound N-alkylation of this compound provides
disubstituted uracils. The structure of the synthesized compounds was studied by H1
and 13С NMR spectroscopy
and their relative antioxidant activity was evaluated by luminol-dependent chemiluminescence measurements.