outbred male
mice. In Experiment 1, we assessed the antidepressant effect of N-199/1 in the forced
administered singly to
white outbred male
mice at a dose of 2 mg/kg.
Results and discussion: N-199/1 reduced
action on GABA-ergic neurotransmission in brains of
outbred white mice. M-20 at a dose of 12 mg
and fluoxetine) were administered once intraperitoneally to
outbred male
mice 4 h (Experiment 1) and 18 h
Valeeva, L.A.,
Davlyatova, G.G.,
Shabalina, Yu.V.,
Isakova, A.V.,
Khaliullin, F.A.,
Nikitina, I.L. (2016) spectroscopic data. The acute toxicity was studied. The LD50 values were 700 mg/kg for
outbred albino
mice. Tail
of experiments in
white outbred male rats. In Experiment 1, reserpine (0.5 mg/kg) was administered