@article{D’yakonov, Vladimir A.2018-03-12,
author = { D’yakonov, Vladimir A.,  Kadikova, Gulnara N.,  Dzhemileva, Lilya U.,  Gazizullina, Guzel F.,  Ramazanov, Ilfir R.,  Dzhemilev, Usein M.},
title = {},
year = {2017},
doi = {10.1021/acs.joc.6b02540},
publisher = {NP «NEICON»},
abstract = {A new, effective catalytic system based on Co(acac)2 has been developed for [6 + 2] cycloaddition of terminal alkynes to 1,3,5,7-cyclooctatetraene to give substituted bicyclo[4.2.2]deca-2,4,7,9-tetraenes in high yields (68–85%). The electrophilic activation of double bonds in the bicyclic products with m-CPBA is an efficient method for the synthesis of substituted bicyclo[4.3.1]deca-2,4,8-triene-7,10-diols, which form the key structural moieties of numerous natural biologically active compounds. The structures of the obtained compounds were reliably proven by modern spectral methods and X-ray diffraction. The mechanism of the discovered rearrangement was studied both using deuterium-labeled bicyclo[4.2.2]deca-2,4,7,9-tetraenes and utilizing quantum chemical calculations. The obtained substituted bicyclo[4.3.1]deca-2,4,8-triene-7,10-diols and their keto derivatives showed high antitumor activity in vitro against Hek293, Jurkat, K562, and A549 tumor cell lines.},
URL = {https://repo.bashgmu.ru/publication/956},
eprint = {https://repo.bashgmu.ru/files/1084},
}