RT - Article
SR - Electronic
T1 - 
SP - 2018-03-14
A1 - Baltina, L.A., 
A1 - Stolyarova, O.V., 
A1 - Kondratenko, R.M., 
A1 - Gabbasov, T.M., 
A1 - Baltina, L.A., 
A1 - Plyasunova, O.A., 
A1 - Il’ina, T.V., 
YR - 2014
UL - https://repo.bashgmu.ru/publication/767
AB - The glycyrrhizic acid (GA) analog olean-9(11),12(13)-dien-30-oic acid 3β-(2-O-β-D-glucuronopyranosyl-β-D-glucuronopyranoside) (II) was synthesized via reduction of GA by NaBH4 in refluxing 2-PrOH:H2O with subsequent work up with HCl (5%). The cytotoxicity and antiviral activity of this glycoside against HIV-1 was studied in MT-4 cell culture. It was found that II was practically non-toxic for MT-4 cells while inhibiting accumulation of virus-specific protein p24 and RNA-dependent DNA-polymerase activity of HIV-1 reverse transcriptase (RT) (IC50 3.1 ±1.0 μg/mL).