TY  - JOUR
T1  - 
AU  - Kataev, V.A, 
AU  - Tyurenkov, I.N., 
AU  - Meshcheryakova, S.A., 
AU  - Perfilova, V.N., 
AU  - Munasipova, D.A., 
AU  - Borodin, D.D., 
Y1  - 2018-03-14
UR  - https://repo.bashgmu.ru/publication/727
N2  - Oxo- and dioxothietane derivatives of 6-methyl-1-(thietan-3-yl)pyrimidine-2,4-(1H,3H)-dione were synthesized
by oxidation. N-Alkylation and CH-aminomethylation produced 3-alkyl- and 5-aminomethyl-substituted
6-methyl-1-(thietan-3-yl)pyrimidine-2,4-(1H,3H)-dione, 6-methyl-1-(1-oxothietan-3-yl)pyrimidine2,4-(1H,3H)-dione,
and 1-(1,1-dioxothietan-3-yl)-6-methylpyrimidine-2,4-(1H,3H)-dione. The synthesized
compounds showed hypotensive activity. Compounds causing pronounced, prolonged, and dose-dependent
hypotensive effects that were comparable with those of reference drugs nebivolol (2 mg/kg), lisinopril
(10 mg/kg), and amlodipine (1 mg/kg) were discovered.