%0 Article
%A Kataev, V.A, 
%A Tyurenkov, I.N., 
%A Meshcheryakova, S.A., 
%A Perfilova, V.N., 
%A Munasipova, D.A., 
%A Borodin, D.D., 
%T 
%D 2014
%X Oxo- and dioxothietane derivatives of 6-methyl-1-(thietan-3-yl)pyrimidine-2,4-(1H,3H)-dione were synthesized
by oxidation. N-Alkylation and CH-aminomethylation produced 3-alkyl- and 5-aminomethyl-substituted
6-methyl-1-(thietan-3-yl)pyrimidine-2,4-(1H,3H)-dione, 6-methyl-1-(1-oxothietan-3-yl)pyrimidine2,4-(1H,3H)-dione,
and 1-(1,1-dioxothietan-3-yl)-6-methylpyrimidine-2,4-(1H,3H)-dione. The synthesized
compounds showed hypotensive activity. Compounds causing pronounced, prolonged, and dose-dependent
hypotensive effects that were comparable with those of reference drugs nebivolol (2 mg/kg), lisinopril
(10 mg/kg), and amlodipine (1 mg/kg) were discovered.
%U https://repo.bashgmu.ru/publication/727