@article{Kataev, V.A2018-03-14,
author = { Kataev, V.A,  Tyurenkov, I.N.,  Meshcheryakova, S.A.,  Perfilova, V.N.,  Munasipova, D.A.,  Borodin, D.D.},
title = {},
year = {2014},
publisher = {NP «NEICON»},
abstract = {Oxo- and dioxothietane derivatives of 6-methyl-1-(thietan-3-yl)pyrimidine-2,4-(1H,3H)-dione were synthesized
by oxidation. N-Alkylation and CH-aminomethylation produced 3-alkyl- and 5-aminomethyl-substituted
6-methyl-1-(thietan-3-yl)pyrimidine-2,4-(1H,3H)-dione, 6-methyl-1-(1-oxothietan-3-yl)pyrimidine2,4-(1H,3H)-dione,
and 1-(1,1-dioxothietan-3-yl)-6-methylpyrimidine-2,4-(1H,3H)-dione. The synthesized
compounds showed hypotensive activity. Compounds causing pronounced, prolonged, and dose-dependent
hypotensive effects that were comparable with those of reference drugs nebivolol (2 mg/kg), lisinopril
(10 mg/kg), and amlodipine (1 mg/kg) were discovered.},
URL = {https://repo.bashgmu.ru/publication/727},
eprint = {https://repo.bashgmu.ru/files/840},
}