%0 Article
%A Mike Saji, 
%A Marc Katz, 
%A Gorav Ailawadi, 
%A Dale Fowler, 
%A Damien LaPar, 
%A Leora Yarboro, 
%A Ravi Ghanta, 
%A John Kern, 
%A John Dent, 
%A Michael Ragosta, 
%A Scott Lim, 
%T 
%D 2016
%X This study aimed to determine if age-adjusted Charlson comorbidity index could predict mortality in patients undergoing transcatheter mitral valve repair (TMVR), and to assess its discriminatory performance in long-term outcomes. Comorbidity increases markedly with aging, and they often negatively impact its prognosis. Although mortality with TMVR is significantly less than for open mitral valve surgery in this population, it remains a concern to identify which patients will benefit from this treatment. Some prognostic metrics have been reported to guide better patient selection, however, universal risk stratification measures in this population, have not been established.

Methods
We retrospectively reviewed 222 patients undergoing TMVR. Cox proportional hazard models were applied to select the demographic characteristics that were associated with cumulative mortality. Receiver operating-characteristic analyses were performed for predicting all-cause mortality, and discriminatory performance was assessed.

Results
We found age-adjusted Charlson comorbidity index (hazard ratio 1.33, 95% confidence interval 1.16–1.51, p 
%U https://repo.bashgmu.ru/publication/694