TY  - JOUR
T1  - 
AU  - Baigildina, Asia A, 
AU  - Khaiboullina, Svetlana F, 
AU  - Martynova, Ekaterina V, 
AU  - Anokhin, Vladimir A, 
AU  - Lombardi, Vincent C, 
AU  - Rizvanov, Albert A, 
Y1  - 2018-02-28
UR  - https://repo.bashgmu.ru/publication/693
N2  - Aims: Nephropathia epidemica (NE) is a form of hemorrhagic fever with renal syndrome
associated with the Puumala virus species of Hantavirus. The pathogenesis of NE is
not well understood; therefore, investigating the inflammatory cytokine response
to infection may provide useful knowledge in deciphering the pathophysiology of
NE. Materials & methods: Using Luminex and ELISA, we analyzed the serum of 137
NE cases and 44 controls to investigate if serum cytokines associate with different
clinical presentations. Results: Serum levels of TNF-α and IL-1β are associated with
disease severity while upregulation of IL-6, CXCL10, CCL2 and CCL3 are associated with
clinical presentation. Conclusion: Inflammatory cytokine kinetics associate with the
severity and phase of NE. Our data support a role for inflammatory cytokines in the
pathophysiology of NE.