17 Baigildina, Asia A Khaiboullina, Svetlana F Martynova, Ekaterina V Anokhin, Vladimir A Lombardi, Vincent C Rizvanov, Albert A 2015 2018-02-28 Aims: Nephropathia epidemica (NE) is a form of hemorrhagic fever with renal syndrome associated with the Puumala virus species of Hantavirus. The pathogenesis of NE is not well understood; therefore, investigating the inflammatory cytokine response to infection may provide useful knowledge in deciphering the pathophysiology of NE. Materials & methods: Using Luminex and ELISA, we analyzed the serum of 137 NE cases and 44 controls to investigate if serum cytokines associate with different clinical presentations. Results: Serum levels of TNF-α and IL-1β are associated with disease severity while upregulation of IL-6, CXCL10, CCL2 and CCL3 are associated with clinical presentation. Conclusion: Inflammatory cytokine kinetics associate with the severity and phase of NE. Our data support a role for inflammatory cytokines in the pathophysiology of NE. https://repo.bashgmu.ru/publication/693 https://repo.bashgmu.ru/files/794