@article{D’yakonov, V.A.2018-02-27,
author = { D’yakonov, V.A.,  Dzhemileva, L.U.,  Tuktarova, R.A.,  Makarov, A.A.,  Islamov, I.I.,  Mulyukova, A.R.,  Dzhemilev, U.M.},
title = {CATALYTIC CYCLOMETALLATION IN STEROID CHEMISTRY III1 : SYNTHESIS OF STEROIDAL DERIVATIVES OF 5Z,9Z-DIENOIC ACID AND INVESTIGATION OF ITS HUMAN TOPOISOMERASE I INHIBITORY ACTIVITY},
year = {2015},
publisher = {NP «NEICON»},
abstract = {Two approaches to stereoselective synthesis of steroid 5Z,9Z-dienoic acids were developed, the first one being based on the cross-cyclomagnesiation of 2-(hepta-5,6-dien-1-yloxy)tetrahydro-2H-pyran and 1,2-diene cholesterol derivatives on treatment with EtMgBr catalyzed by Cp2TiCl2, while the other involving the synthesis of esters of hydroxy steroids with (5Z,9Z)-tetradeca-5,9-dienedioic acid, prepared in two steps using homo-cyclomagnesiation of 2-(hepta-5,6-dien-1-yloxy)tetrahydro-2H-pyran as the key step. High inhibitory activity of the synthesized acids against human topoisomerase I (hTop1) was found.},
URL = {https://repo.bashgmu.ru/publication/674},
eprint = {https://repo.bashgmu.ru/files/762},
}