TY  - JOUR
T1  - 
AU  - Дьяконов, В.А., 
AU  - Джемилева, Л.У., 
AU  - Туктарова, Р.А., 
AU  - Макаров, А.А., 
AU  - Исламов, И.И., 
AU  - Мулюкова, А.Р., 
AU  - Джемилев, У.М., 
AU  - , 
AU  - , 
AU  - , 
AU  - , 
AU  - , 
AU  - , 
Y1  - 2018-01-11
UR  - https://repo.bashgmu.ru/publication/609
N2  - Two approaches to stereoselective synthesis of steroid 5Z,9Z-dienoic acids were developed, the first one being based on the cross-cyclomagnesiation of 2-(hepta-5,6-dien-1-yloxy)tetrahydro-2H-pyran and 1,2-diene cholesterol derivatives on treatment with EtMgBr catalyzed by Cp2TiCl2, while the other involving the synthesis of esters of hydroxy steroids with (5Z,9Z)-tetradeca-5,9-dienedioic acid, prepared in two steps using homo-cyclomagnesiation of 2-(hepta-5,6-dien-1-yloxy)tetrahydro-2H-pyran as the key step. High inhibitory activity of the synthesized acids against human topoisomerase I (hTop1) was found.