17 Дьяконов, В.А. Джемилева, Л.У. Туктарова, Р.А. Макаров, А.А. Исламов, И.И. Мулюкова, А.Р. Джемилев, У.М. 2015 2018-01-11 Two approaches to stereoselective synthesis of steroid 5Z,9Z-dienoic acids were developed, the first one being based on the cross-cyclomagnesiation of 2-(hepta-5,6-dien-1-yloxy)tetrahydro-2H-pyran and 1,2-diene cholesterol derivatives on treatment with EtMgBr catalyzed by Cp2TiCl2, while the other involving the synthesis of esters of hydroxy steroids with (5Z,9Z)-tetradeca-5,9-dienedioic acid, prepared in two steps using homo-cyclomagnesiation of 2-(hepta-5,6-dien-1-yloxy)tetrahydro-2H-pyran as the key step. High inhibitory activity of the synthesized acids against human topoisomerase I (hTop1) was found. https://repo.bashgmu.ru/publication/609 https://repo.bashgmu.ru/files/655