%0 Article
%A Дьяконов, В.А., 
%A Джемилева, Л.У., 
%A Туктарова, Р.А., 
%A Макаров, А.А., 
%A Исламов, И.И., 
%A Мулюкова, А.Р., 
%A Джемилев, У.М., 
%A , 
%A , 
%A , 
%A , 
%A , 
%A , 
%T 
%D 2015
%X Two approaches to stereoselective synthesis of steroid 5Z,9Z-dienoic acids were developed, the first one being based on the cross-cyclomagnesiation of 2-(hepta-5,6-dien-1-yloxy)tetrahydro-2H-pyran and 1,2-diene cholesterol derivatives on treatment with EtMgBr catalyzed by Cp2TiCl2, while the other involving the synthesis of esters of hydroxy steroids with (5Z,9Z)-tetradeca-5,9-dienedioic acid, prepared in two steps using homo-cyclomagnesiation of 2-(hepta-5,6-dien-1-yloxy)tetrahydro-2H-pyran as the key step. High inhibitory activity of the synthesized acids against human topoisomerase I (hTop1) was found.
%U https://repo.bashgmu.ru/publication/609