@article{Дьяконов, В.А.2018-01-11,
author = { Дьяконов, В.А.,  Джемилева, Л.У.,  Туктарова, Р.А.,  Макаров, А.А.,  Исламов, И.И.,  Мулюкова, А.Р.,  Джемилев, У.М., , , , , , },
title = {},
year = {2015},
publisher = {NP «NEICON»},
abstract = {Two approaches to stereoselective synthesis of steroid 5Z,9Z-dienoic acids were developed, the first one being based on the cross-cyclomagnesiation of 2-(hepta-5,6-dien-1-yloxy)tetrahydro-2H-pyran and 1,2-diene cholesterol derivatives on treatment with EtMgBr catalyzed by Cp2TiCl2, while the other involving the synthesis of esters of hydroxy steroids with (5Z,9Z)-tetradeca-5,9-dienedioic acid, prepared in two steps using homo-cyclomagnesiation of 2-(hepta-5,6-dien-1-yloxy)tetrahydro-2H-pyran as the key step. High inhibitory activity of the synthesized acids against human topoisomerase I (hTop1) was found.},
URL = {https://repo.bashgmu.ru/publication/609},
eprint = {https://repo.bashgmu.ru/files/655},
}