%0 Article
%A Дьяконов, В.А., 
%A Джемилева, Л.У., 
%A Макаров, А.А., 
%A Мулюкова, А.Р., 
%A Хуснутдинова, Э.К., 
%A Джемилев, У.М., 
%A , 
%A , 
%A , 
%A , 
%A , 
%A , 
%A , 
%A , 
%T 
%D 2015
%X (5Z,9Z)-11-Phenylundeca-5,9-dienoic acid was stereoselectively synthesized, based on original crosscyclomagnesiation
of 2-(hepta-5,6-dien-1-yloxy)tetrahydro-2H-pyran and buta-2,3-dien-1-ylbenzene
with EtMgBr in the presence of Cp2TiCl2 catalyst giving 2,5-dialkylidenemagnesacyclopentane in 86%
yield. The acid hydrolysis of the product and the Jones oxidation of the resulting 2-{[(5Z,9Z)-11-phenylundeca-
5,9-dien-1-yl]oxy}tetrahydro-2H-pyran afforded (5Z,9Z)-11-phenylundeca-5,9-dienoic acid
in an overall yield of 75%. A high inhibitory activity of the synthesized acid with respect to human
topoisomerase I (hTop1) and II (hTop2a) was determined.
%U https://repo.bashgmu.ru/publication/607