PT - JOURNAL ARTICLE
AU - Камилов, Ф.Х., 
AU - Мамцев, А.Н., 
AU - Козлов, В.Н., 
AU - Абдуллина Г.М., 
AU - Лобырева, О.В., 
AU - , 
AU - , 
AU - , 
AU - , 
TI - АКТИВНОСТЬ АНТИОКСИДАНТНЫХ ФЕРМЕНТОВ И ПРОЦЕССЫ СВОБОДНОРАДИКАЛЬНОГО ОКИСЛЕНИЯ ПРИ ЭКСПЕРИМЕНТАЛЬНОМ ГИПОТИРЕОЗЕ И КОРРЕКЦИИ ТИРЕОИДНЫХ СДВИГОВ ЙОДИРОВАННЫМ ПОЛИСАХАРИДНЫМ КОМПЛЕКСОМ
DP - 2018-01-15
SO - https://repo.bashgmu.ru/publication/600
AB - Aim. To determine the activity of antioxidant enzymes in rat liver tissue on the background of thiamazole hypothyroidism, and also after its correction with iodine-containing organo-mineral complexes. Methods. Studies were conducted on rats, which were divided into four groups: the first group — the control, in animals of the second, third and fourth groups hypothyroidism was induced by daily intragastric administration of thiamazole at a dose 2.5 mg per 100 g body weight for the duration of 3 weeks. Beginning from the 22-day of the experiment the animals of the fourth group for the duration of a month received a biologically active additive in a dose that provides the daily requirement of iodine in rats, while the animals of the third group were on the standard diet of the vivarium. The activity of superoxide dismutase and glutathione peroxidase was determined using a set of reagents «RANSOD Randox» manufactured by «Laboratories Ltd.», the catalase activity was determined by the method of M.A. Korolyuk. Results. Experimental hypothyroidism in rats was characterized by a decrease in the concentrations of free thyroxine, an increase in the content of total triiodothyronine and thyroid-stimulating hormone. In animals treated with tiamazol, the superoxide dismutase activity was 85.6% of the activity level of the control animals, glutathione activity — 77.3% of the level of intact animals. The catalase activity in hypothyroidism decreased significantly — down to 40% of the control level (p